Results 141 to 150 of about 1,132,072 (314)

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

The linear sensitivity of helioseismic ring diagrams to local flows

, 2006
Ring-diagram analysis is a technique of local helioseismology used to infer plasma flows in the solar convection zone which generates intermediate data products known as ring-fitting parameters.
Gizon, Laurent, A. C. Birch, Birch, A. C., D. A. Haber, L. Gizon, Birch, Aaron C., B. W. Hindman, Birch, A., Hindman, B. W., Gizon, L., Haber, D. A., Haber, D., Hindman, B.   +12 more
core   +1 more source

Learning locality-sensitive bucketing functions

Bioinformatics
Abstract Motivation Many tasks in sequence analysis ask to identify biologically related sequences in a large set. The edit distance, being a sensible model for both evolution and sequencing error, is widely used in these tasks as a measure.
Xin Yuan, Ke Chen 0011, Xiang Li 0216, Qian Shi 0006, Mingfu Shao   +4 more
openaire   +2 more sources

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

A modified Morris screening protocol for sensitivity analysis and calibration of green roof parameters in SWMM

City and Environment Interactions
In the calibration process of urban flood and non-point source pollution models, obtaining sufficient site-specific sensitive parameters and their variation trends remains challenging. In this study, a modified Morris screening method was established and
Lihua Yang, Jie Wang, Songwen Yang, Mingming Wang, Long Li, Tie Chen, Liang Feng   +6 more
doaj   +1 more source

A Sensitivity Approach to Force Calculation in Electrostatic MEMS Devices

, 2007
This paper presents a novel method for the computation of force in an electrostatically operated MEMS device. The approach is based on Continuum Design Senstivity Analysis (CDSA) and can be used with any analysis system.
Lowther, D. A., Lowther, D.A., Min Li, Kim, D.H., Dong-hun Kim, Sykulski, J. K., Sykulski, J.K., Jan K. Sykulski, David A. Lowther, Li, M., Kim, D. H.   +10 more
core  

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

A Local Sensitivity Analysis of the Trial of Continuous or Interrupted Chest Compressions during Cardiopulmonary Resuscitation: Is a Local Protocol Change Required? [PDF]

Cureus, 2018
Grunau B, Singer J, Lee T, Scheuermeyer FX, Straight R, Schlamp R, Wand R, Dick WF, Connolly H, Pennington S, Christenson J.   +10 more
europepmc   +1 more source

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source

Local sensitivity of density bounded priors

Local sensitivity for certain density bounded class of priors are considered. We give an exact form of the local sensitivity of the posterior mean and the posterior median, and also investigate the behavior of these local sensitivity measures for varying
Meng, Q., Sivaganesan, S.
core