Results 121 to 130 of about 9,307,023 (310)

Both local stability and dispersal contribute to metacommunity sensitivity to asynchronous habitat availability

Scientific Reports
The stability of isolated communities depends on the complexity of their foodwebs. However, it remains unclear how local stability interacts with dispersal in multitrophic metacommunities to shape biodiversity patterns.
Pablo Moisset de Espanés, Rodrigo Ramos-Jiliberto   +1 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Local sensitivity in econometrics [PDF]

, 2006
The study of the effect of the violations of the model assumptions on the parameter of interest is called sensitivity analysis. Chapter 2 of this thesis defines the sensitivity statistic and confronts sensitivity analysis with diagnostic testing in a general maximum likelihood framework.
openaire   +2 more sources

Learning locality-sensitive bucketing functions

Bioinformatics
Abstract Motivation Many tasks in sequence analysis ask to identify biologically related sequences in a large set. The edit distance, being a sensible model for both evolution and sequencing error, is widely used in these tasks as a measure.
Xin Yuan, Ke Chen 0011, Xiang Li 0216, Qian Shi 0006, Mingfu Shao   +4 more
openaire   +2 more sources

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

A modified Morris screening protocol for sensitivity analysis and calibration of green roof parameters in SWMM

City and Environment Interactions
In the calibration process of urban flood and non-point source pollution models, obtaining sufficient site-specific sensitive parameters and their variation trends remains challenging. In this study, a modified Morris screening method was established and
Lihua Yang, Jie Wang, Songwen Yang, Mingming Wang, Long Li, Tie Chen, Liang Feng   +6 more
doaj   +1 more source

A Local Sensitivity Analysis of the Trial of Continuous or Interrupted Chest Compressions during Cardiopulmonary Resuscitation: Is a Local Protocol Change Required? [PDF]

Cureus, 2018
Grunau B, Singer J, Lee T, Scheuermeyer FX, Straight R, Schlamp R, Wand R, Dick WF, Connolly H, Pennington S, Christenson J.   +10 more
europepmc   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source