Results 101 to 110 of about 1,132,072 (314)
Efficient computation of spaced seeds
BMC Research Notes, 2012 Background The most frequently used tools in bioinformatics are those searching for similarities, or local alignments, between biological sequences. Since the exact dynamic programming algorithm is quadratic, linear-time heuristics such as BLAST are used.
Ilie Silvana
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Cluster sample inference using sensitivity analysis: the case with few groups [PDF]
This paper re-examines inference for cluster samples. Sensitivity analysis is proposed as a new method to perform inference when the number of groups is small.
Vikström, Johan
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Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Estimation in causal graphical models [PDF]
Pearl (2000), Spirtes et al (1993) and Lauritzen (2001) set up a new framework to encode the causal relationships between the random variables by a causal Bayesian network.
Daneshkhah, Alireza
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Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Sensitivity analysis of EUROSEM using Monte Carlo simulation II: : the effect of rills and rock fragments [PDF]
, 2000 A sensitivity analysis of the surface and catchment characteristics in the European soil erosion model (EUROSEM) was carried out with special emphasis on rills and rock fragment cover.
Poesen, J., Veihe, A., Quinton, John
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Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source
Water Resources Research, 2018 We focus on the joint application of local and global sensitivity analyses to characterize propagation of model parameter uncertainties to outputs of subsurface water geochemical models.
G. Ceriotti +3 more
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Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
RDDA: Rectified Discriminatory Delta-Adjust
IEEE AccessThis paper introduces Rectified Discriminatory Delta-Adjust (RDDA), a novel methodology that enhances interpolation-based predictive modeling through adaptive sensitivity parameters.
Ziad F. Doughan, Sari S. Itani
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