Results 81 to 90 of about 2,912,730 (295)

Using adjoint sensitivity as a local structure function in variational data assimilation [PDF]

Nonlinear Processes in Geophysics, 2001
One approach recently proposed in order to improve the forecast of weather events, such as cyclogenesis, is to increase the number of observations in areas depending on the flow configuration.
G. Hello, F. Bouttier
doaj  

Stellar Populations with ELTs

, 2006
The star formation, mass assembly and chemical enrichment histories of galaxies, and their present distributions of dark matter, remain encoded in their stellar populations. Distinguishing the actual distribution functions of stellar age, metallicity and
Gilmore, Gerard, Wyse, Rosemary F. G.
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Local Buckling Check and Sensitivity Analysis Based on J-lay

Shiyou jixie, 2018
In view of the limitation of the local buckling failure evaluation formula of J-lay based on the natural catenary model, the Winkler foundation modeling is introduced for improvement. The entire suspension section is divided into two sections.
Wang Shuai
doaj  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Time-Dependent Gutzwiller Theory for Multiband Hubbard Models

, 2011
Based on the variational Gutzwiller theory, we present a method for the computation of response functions for multiband Hubbard models with general local Coulomb interactions.
Blaizot J-P, Bünemann J, Bünemann J, Bünemann J, Bünemann J, Bünemann J, Bünemann J, Bünemann J, Bünemann J, E von Oelsen, Ferrero M Cornaglia P S De Leo L Parcollet O Kotliar G Georges A, G Seibold, Gebhard F, Gutzwiller M C, Gutzwiller M C, Günther F, J Bünemann, Kubo R, Mahan G D, Ring P, Vollhardt D, Zhuang J N   +21 more
core   +2 more sources

Local Sensitivity Approximations for Selectivity Bias

Journal of the Royal Statistical Society Series B: Statistical Methodology, 2001
Summary Observational data analysis is often based on tacit assumptions of ignorability or randomness. The paper develops a general approach to local sensitivity analysis for selectivity bias, which aims to study the sensitivity of inference to small departures from such assumptions.
Copas, John, Eguchi, Shinto
openaire   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Sensitivity Analysis of Axial Compressive Bearing Capacity of CFRP Concrete-filled Steel Tube

Renmin Zhujiang, 2021
The axial compressive bearing capacity of CFRP concrete-filled steel tube is related to many factors.Due to material manufacturing and use,these parameters are not a definite value.Based on this,this paper carries out the sensitivity analysis of axial ...
WU Jian, ZOU Hong, XU Zhichun, WANG Kunyun   +3 more
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