Results 81 to 90 of about 9,307,023 (310)
Local Buckling Check and Sensitivity Analysis Based on J-lay
Shiyou jixie, 2018 In view of the limitation of the local buckling failure evaluation formula of J-lay based on the natural catenary model, the Winkler foundation modeling is introduced for improvement. The entire suspension section is divided into two sections.
Wang Shuai
doaj
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
The local immune landscape determines tumor PD-L1 heterogeneity and sensitivity to therapy.
Journal of Clinical Investigation, 2019 PD-L1 is a promising therapeutic target in aggressive cancers. However, immune landscapes and cancer hallmarks of human PD-L1+ tumors, as well as their roles in determining therapeutic efficacies are unknown.
Yuan Wei +11 more
semanticscholar +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Sensitivity Analysis of Axial Compressive Bearing Capacity of CFRP Concrete-filled Steel Tube
Renmin Zhujiang, 2021 The axial compressive bearing capacity of CFRP concrete-filled steel tube is related to many factors.Due to material manufacturing and use,these parameters are not a definite value.Based on this,this paper carries out the sensitivity analysis of axial ...
WU Jian +3 more
doaj
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
AgricultureThe early design parameters exert a considerable influence on the cooling energy demand of a granary building in operation. In order to investigate the impact of various parameters on energy use, a grain warehouse energy model was constructed using the ...
Hua Zhang +4 more
doaj +1 more source
Multi-risk assessment: a sensitivity test for a local-scale semi-quantitative methodology
Chemical Engineering Transactions, 2019 A semi-quantitative methodology at a local scale is presented, aimed at increasing the efficacy of Land Use Planning related to the Management of risks, in particular for multiple risks impinging on the same territory (Multi-risks).
Eleonora Pilone +2 more
doaj +1 more source
Local and global parameter sensitivity within an ecophysiologically based forest landscape model
Environmental Modelling & Software, 2019 Forest landscape models (FLM) are widely used for simulating forest ecosystems. As FLMs have become more mechanistic, more input parameters are required, which increases model parameter uncertainty.
Patrick F. McKenzie +3 more
semanticscholar +1 more source