Results 61 to 70 of about 2,912,730 (295)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Flow-Sensitive Fault Localization [PDF]
, 2013 Identifying the cause of an error is often the most time-consuming part in program debugging. Fault localization techniques can help to automate this task. Particularly promising are static proof-based techniques that rely on an encoding of error traces into trace formulas. By identifying irrelevant portions of the trace formula, the possible causes of
Jürgen Christ +3 more
openaire +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Rash impulsiveness and negative mood, but not alexithymia or reward sensitivity, differentiate young to middle-aged chronic daily smokers from never-smokers [PDF]
, 2017 Given the well-established associations of the personality traits alexithymia, impulsivity, and reward sensitivity with problematic use of a variety of substances, including alcohol and cannabis, the present study sought to determine whether daily ...
Bremner, Monique +3 more
core +1 more source
Learning locality-sensitive bucketing functions
BioinformaticsAbstract Motivation Many tasks in sequence analysis ask to identify biologically related sequences in a large set. The edit distance, being a sensible model for both evolution and sequencing error, is widely used in these tasks as a measure.
Xin Yuan +4 more
openaire +2 more sources
Near-Optimal Euclidean Locality-Sensitive Orderings
, 2023 $ \newcommand{\Re}{\mathbb{R}} \newcommand{\reals}{\mathbb{R}} \newcommand{\SetX}{\mathsf{X}} \newcommand{\rad}{r} \newcommand{\Eps}{\Mh{\mathcal{E}}} \newcommand{\p}{\Mh{p}} \newcommand{\q}{\Mh{q}} \newcommand{\Mh}[1]{#1} \newcommand{\query}{q} \newcommand{\eps}{\varepsilon} \newcommand{\VorX}[1]{\mathcal{V} \pth{#1}} \newcommand{\Polygon}{\mathsf{P}}
Gao, Zhimeng, Har-Peled, Sariel
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FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
A spatial model of the plant circadian clock reveals design principles for coordinated timing
Molecular Systems Biology, 2022 Individual plant cells possess a genetic network, the circadian clock, that times internal processes to the day‐night cycle. Mathematical models of the clock are typically either “whole‐plant” that ignore tissue or cell type‐specific clock behavior, or ...
Mark Greenwood +2 more
doaj +1 more source
Local magnetic measurements in magnetic circuits with highly nonuniform electromagnetic fields [PDF]
, 2009 In this paper, local magnetic measurements are carried out in magnetic circuits with highly non uniform electromagnetic field patterns, including excitation winding and/or air gaps, as in the case of rotating electrical machines.
Dupré, Luc +1 more
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