Results 61 to 70 of about 1,132,072 (314)

The pyruvate generator is a common phenomenon in mitochondria from different rat and mouse brain regions

FEBS Letters, EarlyView.
The pyruvate generator, which causes activation of respiration by extra‐mitochondrial Ca2+, is also present and functional in rat brainstem mitochondria, as it is in other brain regions. This finding is confirmed by experiments with a fully reconstituted malate–aspartate shuttle (MAS).
Grazyna Debska‐Vielhaber, Niki Karavasili, Matthias Kunz, Zemfira Gizatullina, Timur Gainutdinov, Stefan Vielhaber, Wolfram S. Kunz, Frank N. Gellerich   +7 more
wiley   +1 more source

A spatial model of the plant circadian clock reveals design principles for coordinated timing

Molecular Systems Biology, 2022
Individual plant cells possess a genetic network, the circadian clock, that times internal processes to the day‐night cycle. Mathematical models of the clock are typically either “whole‐plant” that ignore tissue or cell type‐specific clock behavior, or ...
Mark Greenwood, Isao T Tokuda, James C W Locke   +2 more
doaj   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Effect of Distributed Mass on the Node, Frequency, and Sensitivity of Resonant-Mode Based Cantilevers

Sensors, 2017
We derived an analytical expression for a resonant-mode based bi-layered cantilever with distributed mass load. The behavior of mode of vibration, nodal position, frequency shift, as well as sensitivity under different mass load distributions was ...
Kewei Zhang, Qianke Zhu, Zhe Chen
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Local Wisdom, Environmental Sensitivity and Disaster Anticipation in Improving Social Balance of Students in Junior High Schools

Jurnal Teknologi Pendidikan
This study aims to analyze the influence of local wisdom, environmental sensitivity, and disaster anticipation on social balance in Jember Regency. In this study, a social theory is used that underlies that local wisdom, environmental sensitivity, and ...
sukidin sukidin, Sela Rachmawati, Muhammad Naim   +2 more
doaj   +1 more source

Local sensitivity analysis of AquaCrop model for wheat and maize in Qazvin Plain and Moghan Pars-Abad in Iran [PDF]

, 2020
Application of crop models is essential for numerous purposes including prediction of crop yield and water requirement, evaluation of the impact of climate change, drought and management on crop growth and development.
Adabi, Vahid, Azizian, Asghar, Ramezani-Etedali, Hadi, Kaviani, Abbas, Ababaei, Behnam   +4 more
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Using adjoint sensitivity as a local structure function in variational data assimilation [PDF]

Nonlinear Processes in Geophysics, 2001
One approach recently proposed in order to improve the forecast of weather events, such as cyclogenesis, is to increase the number of observations in areas depending on the flow configuration.
G. Hello, F. Bouttier
doaj