Results 41 to 50 of about 1,132,072 (314)

Venous Thromboembolism in Pediatric Bone Sarcoma Patients: A 10‐Year, Single‐Institution Experience Encompassing the COVID‐19 Pandemic

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Osteosarcoma (OS) and Ewing sarcoma (EWS) are the most common primary bone cancers in children, but acute thrombosis is poorly characterized in this population. Our study evaluated the rates of venous thromboembolism (VTE) and associated risk factors in pediatric patients with bone sarcomas treated over a 10‐year period encompassing
Sarah Kappa, Shou Xu, Mark Zobeck, Sarah E. Sartain, Nino Rainusso, Lisa Wang, Nicole Montgomery, Paige Wheaton, Sarah Whittle   +8 more
wiley   +1 more source

Local and global sensitivity analysis of key durability parameters of concrete under chloride environment

Results in Engineering
This study investigates the local and global sensitivity of five critical durability parameters affecting concrete performance in chloride environments: concrete cover thickness (d), apparent chloride diffusion coefficient (Dₐₚₚ), surface chloride ...
Lingjie Wu, Chengjian Yu, Fenfei Shi, Xuping Ni   +3 more
doaj   +1 more source

Heterogeneity in the Global Practice of Central Nervous System Staging in Pediatric Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) involvement in childhood acute lymphoblastic leukemia (ALL) is assessed by cell counting and cytomorphology from cerebrospinal fluid (CSF) and is used for treatment stratification worldwide. The ratio of “CNS2” patients in clinical trials ranges from 3% to 40%, with unclear prognostic significance ...
Laura Almási, Bernadett Borbála Huszti, Gábor Barna, Marko Kavcic, Janez Jazbec, Lennart Lenk, Vera Münch, Sophia Polychronopoulou, Ágnes Márk, Maria Thastrup, Lüder H. Meyer, Kjeld Schmiegelow, Cornelia Eckert, Christina Halsey, Dániel J. Erdélyi   +14 more
wiley   +1 more source

A Network Analysis-Based Distributed Load Shedding Strategy for Voltage Collapse Prevention

IEEE Access, 2019
This paper proposes a network analysis-based distributed load shedding strategy for voltage collapse prevention. The two-level framework of the distributed load shedding strategy is proposed. The lower one is consisted of local load shedding controllers,
Aina Tian, Xiaoming Mou
doaj   +1 more source

Local sensitivity informed anisotropic sparse grid method for uncertainty quantification of chemical kinetics

AIP Advances, 2023
The determination of rate coefficient parameters in detailed chemical kinetic mechanisms through experiments often suffers from avoidable aleatory uncertainty, while the use of reduced mechanisms, based on various reduction methods, introduces epistemic ...
Linying Li, Bin Zhang, Hong Liu
doaj   +1 more source

Global sensitivity analysis of an end-to-end marine ecosystem model of the North Sea : factors affecting the biomass of fish and benthos [PDF]

, 2014
Comprehensive analysis of parameter and driver sensitivity is key to establishing the credibility of models of complex systems. This is especially so for models of natural systems where experimental manipulation of the real-world to provide controlled ...
Speirs, Douglas, Morris, David J., Cameron, Angus I., Morris, David, Heath, Michael, Speir, Douglas C., Heath, Michael R., Cameron, Angus   +7 more
core   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Chronic morphine administration enhances nociceptive sensitivity and local cytokine production after incision

Molecular Pain, 2008
Background - The chronic use of opioids prior to surgery leads to lowered pain thresholds and exaggerated pain levels after these procedures. Several mechanisms have been proposed to explain this heightened sensitivity commonly termed opioid-induced ...
Angst Martin S, Qiao Yanli, Shi Xiaoyou, Liang DeYong, Yeomans David C, Clark J   +5 more
doaj   +1 more source

Neighborhood-Based Local Sensitivity [PDF]

, 2007
We introduce a nonparametric model for sensitivity estimation which relies on generating points similar to the prediction point using its knearest neighbors. Unlike most previous work, the sampled points differ simultaneously in multiple dimensions from the prediction point in a manner dependent on the local density.
openaire   +1 more source