Results 91 to 100 of about 1,132,072 (314)

A Semiparametric Approach for Analyzing Nonignorable Missing Data [PDF]

open access: yes
In missing data analysis, there is often a need to assess the sensitivity of key inferences to departures from untestable assumptions regarding the missing data process.
Yi Qian, Hui Xie, Leming Qu
core  

Estimating sensitivity indices based on Gaussian process metamodels with compactly supported correlation functions

open access: yes
Specific formulae are derived for quadrature-based estimators of global sensitivity indices when the unknown function can be modeled by a regression plus stationary Gaussian process using the Gaussian, Bohman, or cubic correlation functions.
Svenson, Joshua   +3 more
core   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

open access: yesMolecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou   +12 more
wiley   +1 more source

Sufficiency of Local Feedback for Sensor-Actuator Network-Based Control Systems with Distance Sensitivity Properties

open access: yesJournal of Sensor and Actuator Networks, 2013
Timely dissemination of required state information poses a significant challenge in the design of distributed sensor/actuator network-based control systems.
Vinod Kulathumani, Bryan Lemon
doaj   +1 more source

Efficient Force Calculations Based on Continuum Sensitivity Analysis

open access: yes, 2004
Using Continuum Design Sensitivity Analysis (CDSA), in conjunction with the Virtual Work Principle, equations have been derived for calculating forces without the need to solve the adjoint system.
Lowther, D.   +4 more
core  

Local sensitivity approximations for selectivity bias

open access: yes, 2001
Observational data analysis is often based on tacit assumptions of ignorability or randomness. The paper develops a general approach to local sensitivity analysis for selectivity bias, which aims to study the sensitivity of inference to small departures ...
Shinto Eguchi, John Copas
core   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

open access: yesMolecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi   +7 more
wiley   +1 more source

Local and global sensitivity analysis for railway upgrading between hydrogen fuel cell and electrification

open access: yesHigh-Speed Railway
In the field of rail transit, the UK Department of Transport stated that it will realize a comprehensive transformation of UK railways by 2050, abandoning traditional diesel trains and upgrading them to new environmentally friendly trains.
Yizhe Zhang   +4 more
doaj   +1 more source

Home - About - Disclaimer - Privacy