Results 21 to 30 of about 9,023 (169)

Axonal stress kinase activation and tau misbehavior induced by kinesin-1 transport defects [PDF]

, 2009
Many neurodegenerative diseases exhibit axonal pathology, transport defects, and aberrant phosphorylation and aggregation of the microtubule binding protein tau. While mutant tau protein in frontotemporal dementia and parkinsonism linked to chromosome 17
Falzone, Tomas Luis, Goldstein, Lawrence S. B., Lillo, Concepción, Rodrigues, Elizabeth M., Stokin, Gorazd B., Westerman, Eileen L., Williams, David S.   +6 more
core   +1 more source

Ulipristal acetate versus levonorgestrel-releasing intrauterine system for heavy menstrual bleeding: the UCON randomised controlled trial and mechanism of action study

Efficacy and Mechanism Evaluation, 2023
Background Heavy menstrual bleeding affects one in four women and negatively impacts quality of life. The levonorgestrel-releasing intrauterine system is an effective long-term treatment but is discontinued by many due to unpredictable bleeding, or ...
Lucy HR Whitaker, Lee J Middleton, Lee Priest, Smita Odedra, Versha Cheed, Elaine P Nicholls, Alistair RW Williams, Neil Roberts, Clive E Stubbs, Konstantios Tryposkiadis, Hannah Bensoussane, Rohan Chodankar, Alison A Murray, Moira Nicol, Aleksandra O Tsolova, Kaiming Yin, Marcos Cruz, Hui Wei Leow, Lucy E Kershaw, Suzanne L McLenachan, Graham McKillop, Jane Walker, Scott I Semple, T Justin Clark, Mary Ann Lumsden, Dharani K Hapangama, Lucky Saraswat, Siladitya Bhattacharya, Paul Smith, Jane Daniels, Hilary OD Critchley   +30 more
doaj   +1 more source

Volume Estimation of the Thalamus Using Freesurfer and Stereology: Consistency between Methods [PDF]

, 2012
Freely available automated MR image analysis techniques are being increasingly used to investigate neuroanatomical abnormalities in patients with neurological disorders.
Christoph Kellinghaus, E. Bernd Ringelstein, Harald Kugel, Jan S. Gerdes, Katja Deppe, Michael Deppe, Siawoosh Mohammadi, Simon S. Keller, Stefan Evers, Wolfram Schwindt   +9 more
core   +1 more source

ESTIMATION OF MINKOWSKI TENSORS FROM DIGITAL GREY-SCALE IMAGES

Image Analysis and Stereology, 2014
It was shown in Svane (2014b) that local algorithms based on grey-scale images sometimes lead to asymptotically unbiased estimators for surface area and integrated mean curvature. This paper extends the results to estimators for Minkowski tensors.
Anne Marie Svane
doaj   +1 more source

GM-CSF induces noninflammatory proliferation of microglia and disturbs electrical neuronal network rhythms in situ

Journal of Neuroinflammation, 2020
Background The granulocyte-macrophage colony-stimulating factor (GM-CSF) (or CSF-2) is involved in myeloid cell growth and differentiation, and, possibly, a major mediator of inflammation in body tissues. The role of GM-CSF in the activation of microglia
Hasan Onur Dikmen, Marc Hemmerich, Andrea Lewen, Jan-Oliver Hollnagel, Bruno Chausse, Oliver Kann   +5 more
doaj   +1 more source

ON THE PRECISION OF THE NUCLEATOR

Image Analysis and Stereology, 2017
The nucleator is a design unbiased method of local stereology for estimating the volume of a bounded object. The only information required lies in the intersection of the object with an isotropic random ray emanating from a fixed point (called the ...
Javier González-Villa, Marcos Cruz, Luis M. Cruz-Orive   +2 more
doaj   +1 more source

DEVELOPMENT OF A METHOD FOR ANALYZING TOMOGRAPHIC IMAGES OF BONE STRUCTURES

Сучасний стан наукових досліджень та технологій в промисловості, 2020
The subject matter of research in the article is the morphological structure of bone tissue in the lumbar spine, visualized by tomography in the sagittal and axial planes.
Hanna Abramova, Oleh Avrunin
doaj   +1 more source

Cellular Composition of the Brain of a Northern Minke Whale. [PDF]

J Comp Neurol
Avelino‐de‐Souza et al. show that the minke whale has 3.2 billion neurons in the cerebral cortex, as predicted for a generic cetartiodactyl species, which places it and other cetaceans between monkeys and great apes in a ranking of mammal and bird species by total numbers of neurons in the pallium/cerebral cortex.
Avelino-de-Souza K, Patzke N, Karlsson KÆ, Manger PR, Herculano-Houzel S.   +4 more
europepmc   +2 more sources

Proliferative Kidney Disease and Proliferative Darkening Syndrome are Linked with Brown Trout (Salmo trutta fario) Mortalities in the Pre-Alpine Isar River

Pathogens, 2019
For many years, brown trout (Salmo trutta fario) mortalities within the pre-alpine Isar River in Germany were reported by the Bavarian Fisheries Association (Landesfischereiverband Bayern e.V.) and local recreational anglers during August and September ...
Daniela Arndt, Robert Fux, Andreas Blutke, Julia Schwaiger, Mansour El-Matbouli, Gerd Sutter, Martin C. Langenmayer   +6 more
doaj   +1 more source

Neonatal Apex Resection Triggers Cardiomyocyte Proliferation, Neovascularization and Functional Recovery Despite Local Fibrosis

Stem Cell Reports, 2018
Summary: So far, opposing outcomes have been reported following neonatal apex resection in mice, questioning the validity of this injury model to investigate regenerative mechanisms.
Vasco Sampaio-Pinto, Sílvia C. Rodrigues, Tiago L. Laundos, Elsa D. Silva, Francisco Vasques-Nóvoa, Ana C. Silva, Rui J. Cerqueira, Tatiana P. Resende, Nicola Pianca, Adelino Leite-Moreira, Gabriele D'Uva, Sólveig Thorsteinsdóttir, Perpétua Pinto-do-Ó, Diana S. Nascimento   +13 more
doaj   +1 more source