Results 71 to 80 of about 1,270,152 (266)

Impactul culturii organizaționale asupra implementării strategiilor locale

Revista Transilvană de Ştiinţe Administrative
This article explores the role of organizational culture in shaping the effectiveness of local strategy implementation within public administration. In the context of persistent implementation deficits observed at the local level, the study emphasizes ...
Maria Alexandra Medan
doaj  

On Learning the Best Local Balancing Strategy

, 2020
David Murray, Sofiane Benzait, Romain Pacanowski, and Xavier ...
Murray, David, Benzait, Sofiane, Pacanowski, Romain, Granier, Xavier   +3 more
openaire   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Formação de gestores locais de saúde: processos para identificar estratégias de atuação

Revista de Saúde Pública
No Brasil, nos anos recentes, e acompanhando a maior participação dos municípios nas ações de saúde, observa-se a necessidade crescente de instrumentos que possam contribuir para a melhor formação de gestores locais, complementares às atividades de ...
Oswaldo Y. Tanaka, Maria I. B. Nemes, H. Maria D. Novaes, Magnólia G. Bastos, Chester L. G. César, Lúcia F. Riedel, Juliana Rosalen   +6 more
doaj  

Prepared and flexible: Local adaptation strategies for avalanche risk

Cogent Social Sciences, 2018
Living with avalanche risk and road closures is part of everyday life for many communities in avalanche prone areas. This paper illustrates the interplay and dynamics of adaptive capacity and social capital through locally developed adaptation strategies
Grete K. Hovelsrud, Marianne Karlsson, Julia Olsen   +2 more
doaj   +1 more source

Local training and enrichment based on a residual localization strategy

CoRR
To efficiently tackle parametrized multi and/or large scale problems, we propose an adaptive localized model order reduction framework combining both local offline training and local online enrichment with localized error control. For the latter, we adapt the residual localization strategy introduced in [Buhr, Engwer, Ohlberger, Rave, SIAM J.
Tim Keil, Mario Ohlberger, Felix Schindler, Julia Schleuß   +3 more
openaire   +2 more sources

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

The Learning Community as a Local Development Strategy

The Journal of Community Informatics, 2006
The phenomenon of connected communities shows that the Internet can be a powerful tool in promoting cohesiveness between community actors. Since a community's capability to initiate development projects depends to a significant degree on the quality of the relational framework in which the actors operate, we maintain that it is possible to go beyond ...
Bernard Sévigny, Paul Prévost
openaire   +2 more sources