Results 121 to 130 of about 87,777 (313)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Bus Transit Service in Land Development Planning [PDF]

, 2006
This synthesis will be of interest to transit planners and managers and to those who work with them to develop relationships with local governments and other stakeholders that improve the integration of bus transit and land development.
Christopher, Mary Kay
core  

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Transit asset condition reporting [PDF]

, 2011
The purpose of this synthesis was to examine and document the current state of the practice in transit asset condition management. Transit asset management is defined here as a strategic planning process that supports informed capital investment planning
Berrang, Stephen A., McCollom, Brian
core  

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Bicycling and Transit. A Marriage Unrealized [PDF]

, 2010
When effectively integrated with transit services, bicycling may achieve various environmental, health, and congestion-mitigation benefits for communities. A successful marriage between the two will most likely result in increasing (a) the catchment area
Krizek, Kevin J., Stonebraker, Eric W., Kevin J. Krizek, Eric W. Stonebraker   +3 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Understanding transit ridership demand for a multi-destination, multimodal transit network in an American Metropolitan area [PDF]

, 2011
This study examines the factors underlying transit demand in the multi-destination, integrated bus and rail transit network for Atlanta, Georgia. Atlanta provides an opportunity to explore the consequences of a multi-destination transit network for ...
Joroszynski, Michal, Bhattacharya, Torsha, Thompson, Gregory L., Brown, Jeffrey   +3 more
core  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Study on land use characteristics of rail transit TOD sites in new towns—taking Singapore as an example

Journal of Asian Architecture and Building Engineering, 2019
In order to understand the land use characteristics of the rail transit station sites in new towns of high-density Asian city, this study selected six rail transit stations in Singapore as the research objects. Through the GIS spatial analysis, the study
Shaofei Niu, Ang Hu, Zhongwei Shen, Stephen Siu Yu Lau, Xiaoyu Gan   +4 more
doaj   +1 more source