Results 61 to 70 of about 75,250 (266)

Localization of soft modes at the depinning transition [PDF]

Physical Review E, 2018
Revised Section V with new Figure; 18 pages, 14 ...
Cao, Xiangyu, Bouzat, Sebastian, Kolton, Alejandro Benedykt, Rosso, Alberto   +3 more
openaire   +5 more sources

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Popliteal lymphadenectomy for treating metastatic melanoma: case report

São Paulo Medical Journal
CONTEXT: Regional lymph node involvement in patients with malignant melanomas has been associated with poor prognosis. In-transit metastases also lead to poor long-term survival.
Sergio Renato Pais Costa, Sergio Henrique Couto Horta, Alexandre Cruz Henriques   +2 more
doaj   +1 more source

α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates

FEBS Letters, EarlyView.
Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino, Giuliana Fusco, Alfonso De Simone   +2 more
wiley   +1 more source

Applying data science to analyze internal trip capture for station area neighborhoods

Journal of Urban Mobility
Local accessibility, or accessibility by proximity, is a planning priority that is increasingly discussed within the context of the 15-Minute City. The goal of local accessibility is both to facilitate residents’ quality of life and to promote more ...
Louis A. Merlin, Mary A. Asumang, Wen Zhang   +2 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Localism and the Transition movement

Policy Studies, 2013
This article explores the relationship between localism and contemporary community engagement. In particular, it focuses on the Transition movement, an especially interesting case, given its localistic and community-oriented nature. The article begins with a short discussion of more traditional conceptions of localism.
openaire   +4 more sources

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

What the heck is a choice rider? A theoretical framework and empirical model

Journal of Transport and Land Use, 2022
As local, state, and federal agencies began investing substantial resources into subsidizing transit in the 1960s and ‘70s, public documents argued that transit agencies should focus on attracting choice riders instead of dependent riders, who have no ...
Erick Guerra
doaj