Strengths and Silences: The Experiences of Lesbian, Gay, Bisexual and Transgender Students in Rural and Small Town Schools [PDF]
, 2012 For more than 20 years, GLSEN has worked to make schools safer for all students; it has sought specifically to reduce the bullying and harassment targeted at students' sexual orientation, gender identity, and gender expression. For lesbian, gay, bisexual,
Joseph G. Kosciw +2 more
core
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Integration of circadian and hypoxia signaling via non‐canonical heterodimerization
FEBS Letters, EarlyView.CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Les facteurs de variation des performances laitières de la chèvre locale dans les zones arides
Journal of Agriculture and Environment for International Development, 2011 Dans les zones arides tunisiennes, les performances laitières de la chèvre locale synthétisent les capacités génétiques de la population et l’impact des facteurs naturels difficiles.
Ilyes Mekki +2 more
doaj +1 more source
ENJEUX ET DÉFIS DE LA DÉCENTRALISATION ET GOUVERNANCE LOCALE AU TOGO : CAS DES TROIS COMMUNES DE LA PREFECTURE DE DOUFELGOU [PDF]
Ziglôbitha, 2022 Résumé : Au début des années 90, la décentralisation prônée par les agences de coopération internationale connaît un regain d’intérêt. Dans la plupart des pays de l’Afrique de l’Ouest, elle traverse des difficultés dans sa mise en application.
Assindah MAGNETINE, Kékessi Kossi ABOSSE & Kpadakpa TEWALAMBA
doaj
Locally Compact Contractive Local Groups
, 2009 10 ...
van den Dries, Lou, Goldbring, Isaac
openaire +3 more sources
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Rule-based cloud service localisation [PDF]
, 2013 The fundamental purpose of cloud computing is the ability to quickly provide software and hardware resources to global users. The main aim of cloud service localisation is to provide a method for facilitating the internationalisation and localisation of ...
Collins, Luke +2 more
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