Results 131 to 140 of about 1,591,314 (318)
FEBS Letters, EarlyView.This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley +1 more source
DigitalTraditional methods for predicting sow reproductive cycles are not only costly but also demand a larger workforce, exposing workers to respiratory toxins, repetitive stress injuries, and chronic pain.
Iyad Almadani +3 more
doaj +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
, 2007 The aim of this work is to study the strain localization during the plastic deformation of sheets metals. This phenomenon is precursor for the fracture of drawing parts, thus its prediction using advanced behavior models is important in order to obtain ...
BALAN, Tudor +2 more
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Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Frontiers in ImmunologyAs a canonical cytoplasmic DNA sensor, cyclic GMP-AMP synthase (cGAS) plays a key role in innate immunity. In recent years, a growing number of studies have shown that cGAS can also be located in the nucleus and plays new functions such as regulating DNA
Yikai Lu +5 more
doaj +1 more source
Translation and Localization Project Management The art of the possible
The community or "crowdsourcing" project model presents opportunities for organizations to translate content that might otherwise not be financially feasible to offer in other languages.
Dunne, Elena S., Dunne, Keiran J.
core
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Localization: Functional requisites of localized settlements
, 1986 Every social system must provision basic functions if the system is to thrive. These needs may be met at the system level where they are needed or through exchange with other levels or systems.
Feldt, Allan G., De Young, Raymond
core