Results 121 to 130 of about 2,611,515 (289)

Existence, uniqueness, localization and minimization property of positive solutions for non-local problems involving discontinuous Kirchhoff functions

Advances in Nonlinear Analysis
Let Ω⊂Rn\Omega \subset {{\bf{R}}}^{n} be a smooth bounded domain. In this article, we prove a result of which the following is a by-product: Let q∈]0,1[q\in ]0,1{[}, α∈L∞(Ω)\alpha \in {L}^{\infty }\left(\Omega ), with α>0\alpha \gt 0, and k∈Nk\in {\bf{N}}
Ricceri Biagio
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Mixed-state localization operators: Cohen's class and trace class operators

, 2018
We study mixed-state localization operators from the perspective of Werner's operator convolutions which allows us to extend known results from the rank-one case to trace class operators.
Luef, Franz, Skrettingland, Eirik
core  

Localized emphysema [PDF]

Acta Radiologica, 1960
S, BRUNNER, O C, POCK-STEEN
openaire   +2 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Only functional localization is faithful localization

Microbial Cell, 2014
Roland Lill
doaj   +1 more source

Developing a National Guideline for Diagnosis, Treatment and Follow-up of Stroke

Journal of Mazandaran University of Medical Sciences, 2018
Background and purpose: Lack of clear boundaries and standard reference about the diagnosis of stroke, necessary evaluations and interventions, effective treatments, and referral of stroke patients resulted in various inconsistent services.
Rozita Davoodi, Kavian Ghandehari, Mohammad reza Ghayeni, Mohammad hossein Harirchian, Homan Bahar vahdat, Sasan Nezhad, Azadeh Soltani Far, Golnaz Sabouri, Shaghayegh Rahmani, Mahboubeh Asadi, Maryam Zare Hosseini, Mohammad Hadi Saied Modaghegh, Elahe Ghayebie, Farhad Heydarian, Hava Abdollahi, Mahdi Farhodi   +15 more
doaj  

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source