Revealing Microvascular Involvement in Pediatric Localized Scleroderma Through Nailfold Capillaroscopy [PDF]
ChildrenBackground/Objectives: Juvenile localized scleroderma (jLoS) is a chronic inflammatory disorder with skin and subcutaneous tissue involvement. Microvascular alterations are thought to contribute to its pathogenesis.
Sema Nur Taşkın +5 more
doaj +4 more sources
Phosphodiesterase-4 inhibition in localized scleroderma: A case series of topical roflumilast [PDF]
SAGE Open Medical Case ReportsLocalized scleroderma, or morphea, is a chronic fibrosing skin condition with limited therapeutic options, particularly for patients who are elderly, immunocompromized, or intolerant to systemic immunosuppressants.
Ghassan Barnawi +4 more
doaj +3 more sources
High-content Image-based Drug Testing of Patients’ Primary Fibroblasts Reveals Potential New Treatment Options for Localized Scleroderma [PDF]
Acta Dermato-VenereologicaLocalized scleroderma is a rare autoimmune disease characterized by progressive fibrosis of the skin and its underlying structures, causing loss of normal tissue structure and function.
Katariina Mähönen +10 more
doaj +2 more sources
Endpoints and outcomes for localized scleroderma/morphea: a scoping literature review [PDF]
Pediatric Rheumatology Online JournalBackground Current treatment for localized scleroderma (LS) has been shown to halt disease activity, but little is still known about patient experiences with these treatments, nor is there consensus about optimal measurement strategies for future ...
Alexy Hernandez +5 more
doaj +2 more sources
Case Report: Exacerbation after fat grafting in patients with active localized scleroderma [PDF]
Frontiers in SurgeryBackgroundThe application of autologous fat transplantation in facial lesions of patients with localized scleroderma (LoS) has been reported in recent years.ObjectiveThe authors report a case of worsening of active localized scleroderma after autologous ...
Shunxin Han +3 more
doaj +2 more sources
Intramuscular Polydeoxyribonucleotides in Fibrotic and Atrophic Localized Scleroderma: An Explorative Prospective Cohort Study [PDF]
Biomedicines, 2023 Effective options in the quiescent, scantily inflammatory phase of localized scleroderma (morphea) are lacking. A cohort study in patients with histologically confirmed fibroatrophic morphea explored the therapeutic value of the anti-dystrophic A2A ...
Maurizio Romagnuolo +5 more
doaj +2 more sources
Successful treatment of localized scleroderma using brodalumab: A case report [PDF]
SAGE Open Medical Case ReportsWe report the first documented use of brodalumab, an IL-17 receptor antagonist, for treating severe linear localized scleroderma refractory to conventional therapies, including methotrexate, mycophenolate mofetil and corticosteroids.
Alexandra Carla Bobica +4 more
doaj +2 more sources
Juvenile localized scleroderma: a large retrospective cohort study from a tertiary care center [PDF]
Pediatric Rheumatology Online JournalBackground Juvenile localized scleroderma is a rare pediatric inflammatory disease that primarily affects the skin and subcutaneous tissue but also has the potential to impact deeper tissues and can be associated with extracutaneous manifestations ...
Bugra Han Egeli +8 more
doaj +2 more sources
Localized scleroderma: clinical spectrum and therapeutic update [PDF]
Anais Brasileiros de Dermatologia, 2015 Scleroderma is a rare connective tissue disease that is manifested by cutaneous sclerosis and variable systemic involvement. Two categories of scleroderma are known: systemic sclerosis, characterized by cutaneous sclerosis ...
Mariana Figueiroa Careta, Ricardo Romiti
doaj +2 more sources
Вопросы современной педиатрии, 2020 The localized scleroderma (morphea) is the clinical option of the juvenile scleroderma, the third in prevalence rheumatic condition in pediatrics. The article summarizes all the data on the classification, diagnostics, and differential diagnosis of ...
Rinat K. Raupov +2 more
doaj +1 more source