Results 21 to 30 of about 280,125 (195)

Causal Inference using Multivariate Generalized Linear Mixed-Effects Models with Longitudinal Data [PDF]

arXiv, 2023
Dynamic prediction of causal effects under different treatment regimes conditional on an individual's characteristics and longitudinal history is an essential problem in precision medicine. This is challenging in practice because outcomes and treatment assignment mechanisms are unknown in observational studies, an individual's treatment efficacy is a ...
arxiv  

Local copying and local discrimination as a study for non-locality of a set [PDF]

Phys. Rev. A 74, 032108 (2006), 2005
We focus on the non-locality concerning local copying and local discrimination, especially for a set of orthogonal maximally entangled states in prime dimensional systems, as a study of non-locality of a set of states. As a result, for such a set, we completely characterize deterministic local copiability and show that local copying is more difficult ...
arxiv   +1 more source

Bound non-locality and activation [PDF]

Phys. Rev. Lett. 106, 020402 (2011), 2010
We investigate non-locality distillation using measures of non-locality based on the Elitzur-Popescu-Rohrlich decomposition. For a certain number of copies of a given non-local correlation, we define two quantities of interest: (i) the non-local cost, and (ii) the distillable non-locality.
arxiv   +1 more source

The Immune Microenvironment: New Therapeutic Implications in Organ Fibrosis

Advanced Science, EarlyView.
This review summarizes recent advances in understanding the immune microenvironment's role in fibrosis, focusing on phenotypic/functional alterations of immune cells and their dynamic interactions with other cellular constituents within tissues. The authors further explore therapeutic opportunities and challenges in targeting immune microenvironment ...
Xiangqi Chen, Chuan Wu, Fei Tang, Jingyue Zhou, Li Mo, Yanping Li, Jinhan He   +6 more
wiley   +1 more source

Local boundary representations of locally C*-algebras [PDF]

arXiv, 2021
We initiate a study of non-commutative Choquet boundary for spaces of unbounded operators. We define the notion of local boundary representations for local operator systems in locally C$^*$-algebras and prove that local boundary representations provide an intrinsic invariant for a particular class of local operator systems.
arxiv  

Critical Role for Transglutaminase 2 in Scleroderma Skin Fibrosis and in the Development of Dermal Sclerosis in a Mouse Model of Scleroderma

Arthritis &Rheumatology, EarlyView.
Objective Scleroderma is a life‐threatening autoimmune disease characterized by inflammation, tissue remodeling, and fibrosis. This study aimed to investigate the expression and function of transglutaminase 2 (TGM2) in scleroderma skin and experimentally induced dermal fibrosis to determine its potential role and therapeutic implications.
Angela Y. Y. Tam, Korsa Khan, Shiwen Xu, Marianne Bergin, Linghong Huang, Erik Arroyo Colon, Danyi Cheng, Elisabetta A. M. Verderio, Voon Ong, Christopher P. Denton, John Atkinson, Tim S. Johnson, David J. Abraham   +12 more
wiley   +1 more source

Mucosal‐associated invariant T cells in rheumatic diseases.

Arthritis &Rheumatology, Accepted Article.
Mucosal‐associated invariant T (MAIT) cells are innate‐like T cells defined by their semi‐invariant T cell receptor (TCR) and restriction by the MHC class I‐related molecule (MR1). These cells are primarily activated by microbial‐derived metabolites presented by MR1 or by cytokines. Upon activation, MAIT cells rapidly produce pro‐inflammatory cytokines,
Manon Lesturgie‐Talarek, Virginie Gonzalez, Lucie Beaudoin, Noémie Sénot, Corinne Miceli‐Richard, Yannick Allanore, Agnès Lehuen, Jerôme Avouac   +7 more
wiley   +1 more source

Progressive Soft Tissue Swelling in a Pediatric Patient Leading to the Diagnosis of Fibrodysplasia Ossificans Progressiva: A Case Report

Pediatric Dermatology, EarlyView.
ABSTRACT Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disorder characterized by progressive heterotopic ossification (HO) and congenital malformation of the great toes. This case describes a 5‐year‐old Caucasian girl who initially presented with painless neck and back swelling as well as severe limitation of movement in the neck and ...
Orhan Yilmaz, Loretta Fiorillo
wiley   +1 more source

Disturbed Spatial WNT Activation—A Potential Driver of the Reticularized Skin Phenotype in Systemic Sclerosis

Arthritis &Rheumatology, Volume 77, Issue 6, Page 740-749, June 2025.
Objective Little is known on the mechanisms necessary to maintain the physiologic adult human skin integrity. This study aims to quantitatively describe anatomic changes in systemic sclerosis (SSc)–skin compared with controls and investigate the underlying mechanisms.
Sara Chenguiti Fakhouri, Honglin Zhu, Yi‐Nan Li, Moritz Ronicke, Aleix Rius Rigau, Clara Dees, Laura Konstantinidis, Ralf Schmid, Alexandru‐Emil Matei, Markus Eckstein, Carol Geppert, Ingo Ludolph, Alexander Kreuter, Michael Sticherling, Carola Berking, Raymund E. Horch, Georg Schett, Jörg H. W. Distler, Christina Bergmann   +18 more
wiley   +1 more source

Local boundary representations for local operator systems [PDF]

arXiv, 2023
In this paper, we show that the local boundary representations of a local operator system in a Frechet locally C*-algebra on quantized Frechet domains introduced by Arunkumar [Local boundary representations of locally C*-algebras, J. Math. Anal. Appl. 515(2022),2,Paper No.
arxiv