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Locally advanced breast cancer [PDF]

Breast, 2022
Locally advanced breast cancer (LABC) is defined here as inoperable breast adenocarcinoma without distant metastases. Patients with LABC require a multidisciplinary approach. Given the risk of distant metastasis, staging exams are necessary.
Stefan Aebi, Per Karlsson, Irene L. Wapnir   +2 more
doaj   +3 more sources

The health system and access to treatment in patients with cervical cancer in Mexico

Frontiers in Oncology, 2022
Cervical cancer (CC) is tightly related to a low Human Development Index. Mexico is an upper-middle-income country with 126 million inhabitants, and its public health system aims to provide universal health coverage.
Eder A. Arango-Bravo, Eder A. Arango-Bravo, Eder A. Arango-Bravo, Lucely del Carmen Cetina-Pérez, Lucely del Carmen Cetina-Pérez, Lucely del Carmen Cetina-Pérez, Lucely del Carmen Cetina-Pérez, Tatiana Galicia-Carmona, Tatiana Galicia-Carmona, Tatiana Galicia-Carmona, Denisse Castro-Eguiluz, Dolores Gallardo-Rincón, Ivette Cruz-Bautista, Alfonso Duenas-Gonzalez, Alfonso Duenas-Gonzalez   +14 more
doaj   +1 more source

PD-1 Blockade in Mismatch Repair-Deficient, Locally Advanced Rectal Cancer.

New England Journal of Medicine, 2022
BACKGROUND Neoadjuvant chemotherapy and radiation followed by surgical resection of the rectum is a standard treatment for locally advanced rectal cancer. A subset of rectal cancer is caused by a deficiency in mismatch repair.
A. Cercek, M. Lumish, Jenna Sinopoli, Jill A. Weiss, J. Shia, M. Lamendola-Essel, I. El Dika, N. Segal, M. Shcherba, R. Sugarman, Z. Stadler, R. Yaeger, J. Smith, B. Rousseau, G. Argilés, Miteshkumar Patel, A. Desai, L. Saltz, M. Widmar, Krishna Iyer, Janie Y Zhang, Nicole Gianino, C. Crane, P. Romesser, E. Pappou, P. Paty, J. García-Aguilar, M. Gonen, M. Gollub, M. Weiser, K. Schalper, L. Diaz   +31 more
semanticscholar   +1 more source

Neoadjuvant chemotherapy with FOLFIRINOX and preoperative chemoradiotherapy for patients with locally advanced rectal cancer (UNICANCER-PRODIGE 23): a multicentre, randomised, open-label, phase 3 trial.

The Lancet Oncology, 2021
BACKGROUND Treatment of locally advanced rectal cancer with chemoradiotherapy, surgery, and adjuvant chemotherapy controls local disease, but distant metastases remain common.
T. Conroy, J. Bosset, P. Etienne, E. Rio, E. François, N. Mesgouez-Nebout, V. Vendrely, X. Artignan, O. Bouché, D. Gargot, V. Boige, N. Bonichon-Lamichhane, C. Louvet, C. Morand, C. de la Fouchardière, N. Lamfichekh, B. Juzyna, Claire Jouffroy-Zeller, E. Rullier, F. Marchal, S. Gourgou, F. Castan, C. Borg   +22 more
semanticscholar   +1 more source

Neoadjuvant Systemic Therapy for Locally Advanced Breast Cancer in St. Luke’s Medical Center: 10-Year Local Experience and Response Rates

Asian Pacific Journal of Cancer Care, 2023
Background: Neoadjuvant therapy has given important prognostic and predictive information based on pathologic response as seen on studies showing that pathologic complete response (pCR) is associated with favorable disease-free and overall survival in ...
Mel Valerie B. Cruz-Ordinario, May Rose A. Malesido, May N. Sabando, Agnes E. Gorospe, Carlos Dy   +4 more
doaj   +1 more source

Multicenter, Randomized, Phase III Trial of Short-Term Radiotherapy Plus Chemotherapy Versus Long-Term Chemoradiotherapy in Locally Advanced Rectal Cancer (STELLAR)

Journal of Clinical Oncology, 2022
PURPOSE To ascertain if preoperative short-term radiotherapy followed by chemotherapy is not inferior to a standard schedule of long-term chemoradiotherapy in patients with locally advanced rectal cancer.
Jing Jin, Yuan Tang, Chen Hu, Liming Jiang, Jun Jiang, Ning Li, Wenyang Liu, Siyu Chen, Shuai Li, N. Lu, Yong Cai, Yongheng Li, Yuan Zhu, Guang-Hui Cheng, Hong-Yan Zhang, Xin Wang, Su-Yu Zhu, Jun Wang, Gao-Feng Li, Jialin Yang, Kuan Zhang, Y. Chi, Lin Yang, Hai-Tao Zhou, Ai-ping Zhou, S. Zou, H. Fang, Shulian Wang, Hai-zeng Zhang, Xi-shan Wang, Lichun Wei, Wenling Wang, Shi-xin Liu, Yuan-hong Gao, Ye‐Xiong Li   +34 more
semanticscholar   +1 more source

Real World Data of Response of Trastuzumab Based Chemotherapy in Locally Advanced HER2 Positive Breast Cancer from a Developing Country

Asian Pacific Journal of Cancer Care, 2021
Background: Data regarding pathologic response of Trastuzumab based chemotherapy in locally advanced HER2 positive breast cancer in neoadjuvant setting is scarce.
Dinesh Chandra Doval, Sneha Bothra, Pankaj Goyal, Chaturbhuj Agrawal, Parveen Jain, Rupal Tripathi, Anurag Sharma, Sunil Pasricha, Kumardeep Dutta Choudhary   +8 more
doaj   +1 more source

A Retrospective Evaluation of Clinical Profile of Second Primary Head and Neck Cancer [PDF]

Journal of Clinical and Diagnostic Research, 2016
Introduction: Incidence of Second Primary Malignancy (SPM) after successful treatment of primary is increasing and may cause the problem for optimal treatment.
Paramjeet Kaur, Nupur Bansal, J Vijaya Kumar, Anil Khurana, Ashok Chauhan   +4 more
doaj   +1 more source

Patterns of failure in locally advanced female breast carcinoma treated with neoadjuvant chemotherapy followed by surgery and radiotherapy – A prospective study

Asian Journal of Medical Sciences, 2023
Background: The use of combined modality therapy including surgery, chemotherapy, and radiotherapy increases five survival rates in stage IIA and stage IIIB disease to 80% and 45%, respectively. Neoadjuvant chemotherapy (NACT) eradicates micro metastasis
Shilpi Adhikary , Dibyendu Saha , Bidisha Bandyopadhyay , Chandan Dasgupta , Soham Gangopadhyay , Anjan Bera   +5 more
doaj   +1 more source

Using patient-derived organoids to predict locally advanced or metastatic lung cancer tumor response: A real-world study

Cell Reports Medicine, 2023
Summary Predicting the clinical response to chemotherapeutic or targeted treatment in patients with locally advanced or metastatic lung cancer requires an accurate and affordable tool.
Han-Min Wang, Changkai Zhang, K. Peng, Ze-Xin Chen, J.W. Su, Yu‐Fa Li, Wen-Feng Li, Qingmei Gao, Shi-Ling Zhang, Yuqing Chen, Qing Zhou, Congjun Xu, Chongrui Xu, Zhen Wang, J. Su, Hong-Hong Yan, Xuchao Zhang, Hua-jun Chen, Yi‐Long Wu, Jin-Ji Yang   +19 more
semanticscholar   +1 more source