Results 81 to 90 of about 4,204,651 (354)

Excess of weight: is it a modifiable predictive and prognostic factor in locally advanced rectal cancer? [PDF]

, 2017
To evaluate the relationship between body mass index (BMI) and rates of treatment tolerance and clinical outcomes in patients with locally advanced rectal cancer treated with a multimodality approach.
Bulzonetti, N, De Felice, F, Magnante, A. L, Musio, D, Tombolini, V.   +4 more
core  

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

FEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

Duration of chemotherapy prior to chemoradiation affects survival outcomes for resected stage I‐II or unresected stage III pancreatic cancer

Cancer Medicine, 2019
Background For resected early stage pancreatic cancer, RTOG 9704 evaluated the outcome of 3 weeks of postoperative chemotherapy (C) followed by chemoradiation (CRT) and further C.
Sung J. Ma, Austin J. Iovoli, Gregory M. Hermann, Kavitha M. Prezzano, Anurag K. Singh   +4 more
doaj   +1 more source

Candidate circulating microRNAs as potential diagnostic and predictive biomarkers for the monitoring of locally advanced breast cancer patients

Tumor Biology, 2020
This study aimed at investigating the expression of candidate microRNAs (miRs), at initial diagnosis, during neoadjuvant chemotherapy, and after the tumor resection in locally advanced breast cancer patients.
Alaa M Ibrahim, Mahmoud M Said, Amany M Hilal, Amina M Medhat, Ibrahim M Abd Elsalam   +4 more
doaj   +1 more source

Effectiveness of postoperative radiotherapy after radical cystectomy for locally advanced bladder cancer [PDF]

, 2019
BACKGROUND: Local-regional failure (LF) for locally advanced bladder cancer (LABC) after radical cystectomy (RC) is common even with chemotherapy and is associated with high morbidity/mortality.
Andriole, Gerald L, Arora, Vivek, Baumann, Brian C, Bullock, Arnold, DeWees, Todd A, et al,, Figenshau, Robert S, Fischer-Valuck, Benjamin W, Gay, Hiram A, Grubb, Robert L, Kim, Eric, Knoche, Eric M, Michalski, Jeff M, Pachynski, Russell K, Roth, Bruce J, Smith, Zachary L   +15 more
core   +2 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Risk Stratification of Locally Advanced Non-Small Cell Lung Cancer (NSCLC) Patients Treated with Chemo-Radiotherapy: An Institutional Analysis

Cancer Management and Research, 2020
Amna Sher,1 Sowmini Medavaram,1 Barbara Nemesure,2 Sean Clouston,2 Roger Keresztes1 1Department of Medicine, Stony Brook University Hospital, Stony Brook, NY, USA; 2Department of Family, Population and Preventive Medicine, Stony Brook University Hospital,
Sher A, Medavaram S, Nemesure B, Clouston S, Keresztes R   +4 more
doaj  

Relationship between HER2 expression and efficacy with first-line trastuzumab emtansine compared with trastuzumab plus docetaxel in TDM4450g: a randomized phase II study of patients with previously untreated HER2-positive metastatic breast cancer. [PDF]

, 2014
IntroductionThe purpose of this study was to retrospectively explore the relationship between human epidermal growth factor receptor 2 (HER2) messenger RNA (mRNA) expression and efficacy in patients receiving trastuzumab plus docetaxel (HT) or ...
Amler, Lukas C, Gianni, Luca, Guardino, Ellie, Hurvitz, Sara A, Mundt, Kirsten E, Ng, Vivian, Perez, Edith A   +6 more
core   +3 more sources

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Association of Pre- and Posttreatment Neutrophil–Lymphocyte Ratio With Recurrence and Mortality in Locally Advanced Non-Small Cell Lung Cancer

Frontiers in Oncology, 2020
ObjectivesNeutrophil–lymphocyte ratio (NLR) has been associated with mortality in non-small cell lung cancer (NSCLC), but its association with recurrence in locally advanced NSCLC (LA-NSCLC), specifically, is less established.
Nikhil T. Sebastian, Rohit Raj, Rahul Prasad, Christian Barney, Jeremy Brownstein, John Grecula, Karl Haglund, Meng Xu-Welliver, Terence M. Williams, Jose G. Bazan   +9 more
doaj   +1 more source