Results 231 to 240 of about 8,380,026 (270)

Cemiplimab for locally advanced and metastatic basal cell carcinoma

Expert Review of Anticancer Therapy, 2022
Locally advanced basal cell carcinoma (laBCC) represents approximatively 1% of all BCCs. Metastatic BCC (mBCC) is even more rare. Most cases are observed in immunocompromised patients, particularly solid organ transplant recipients (OTRs). When surgery and/or radiation therapy for laBCC or mBCC is not reasonable, oral hedgehog inhibitor (HHI) therapy ...
Thomas Damsin, Eve Lebas, Nathalie Marchal, Andrée Rorive, Arjen F Nikkels   +4 more
openaire   +3 more sources

Radiotherapy for Locally Advanced Basal Cell and Squamous Cell Carcinomas of the Skin

International Journal of Radiation Oncology Biology Physics, 2004
To determine the outcomes of patients with locally advanced basal cell and squamous cell carcinomas of the skin treated with radiotherapy.A retrospective review of the outcomes of patients with basal cell and squamous cell carcinomas treated with radical radiotherapy was conducted.
Winkle Kwan, Veronika Moravan, Don Wilson   +2 more
exaly   +3 more sources

Defining and recognising locally advanced basal cell carcinoma

European Journal of Dermatology, 2015
Rarely, basal cell carcinomas (BCCs) have the potential to become extensively invasive and destructive, a phenomenon that has led to the term "locally advanced BCC" (laBCC). We identified and described the diverse settings that could be considered "locally advanced".The panel of experts included oncodermatologists, dermatological and maxillofacial ...
Amici, J. M., Battistella, M., Beylot-Barry, M., Chatellier, A., Dalac-Ra, S., Dreno, B., Falandry, Claire, Froget, N., Giacchero, D., Grob, J. J., Guerreschir, P., Leccia, M. T., Malard, O., Mortier, L., Routier, E., Stefan, A., Stefan, D., Stoebner, P. E., Basset-Seguin, N.   +18 more
openaire   +3 more sources

Sonidegib: A Review in Locally Advanced Basal Cell Carcinoma

Targeted Oncology, 2016
Sonidegib (Odomzo®), an oral smoothened (SMO) antagonist, is indicated for the treatment of adults with locally advanced basal cell carcinoma (laBCC) who are not candidates for surgery or radiation therapy, or adults with recurrent laBCC following surgery or radiation therapy.
Celeste B, Burness, Lesley J, Scott
openaire   +2 more sources

Treatments on the Horizon for Locally Advanced Basal Cell Carcinoma

Cancer Letters
Basal cell carcinoma (BCC) is one of the most common human cancers. Most cases of BCC are amenable to surgical and topical treatments with excellent prognosis if diagnosed timely and managed appropriately. However, in a small percentage of cases, it could be locally advanced BBC (laBCC) and not amenable to surgery or radiation, including recurrent ...
Michael R Migden
exaly   +3 more sources

The Safety and Efficacy of Sonidegib for the Treatment of Locally Advanced Basal Cell Carcinoma [PDF]

Expert Review of Anticancer Therapy, 2016
Basal cell carcinomas (BCCs) are the commonest malignancy in the Western world. Locally advanced BCCs (laBCCs) represent tumours that have developed in difficult-to-treat facial sites, aggressively recurrent tumours, large neglected tumours and those in which current treatment options are excluded by clinical or patient-driven criteria. It is estimated
John T. Lear, Faisal R Ali
exaly   +3 more sources

Neoadjuvant vismodegib in the management of locally advanced periocular basal cell carcinoma

Eye, 2020
Vismodegib, a hedgehog pathway inhibitor, has been used in the management of locally advanced basal cell carcinoma (BCC) not suitable for surgery or radiation therapy. We report our experience using neoadjuvant vismodegib for locally advanced periocular BCC, followed by surgical excision.
David S. Curragh, Shyamala C. Huilgol, Dinesh Selva   +2 more
openaire   +2 more sources

Clinical and Histopathologic Characteristics of Metastatic and Locally Advanced Cutaneous Basal Cell Carcinomas

The American Journal of Dermatopathology, 2021
Abstract: Locally advanced or metastatic basal cell carcinomas (laBCCs or mBCCs) are rare, with few case series providing information on their epidemiology. We aimed to describe the clinical and histologic features of locally advanced and metastatic basal cell carcinomas.
Laura X, Baker, Erica, Grilletta, Jeffrey P, Zwerner, Alan S, Boyd, Lee, Wheless   +4 more
openaire   +2 more sources