Results 231 to 240 of about 19,218 (261)

Treatments on the horizon for locally advanced basal cell carcinoma

Cancer Letters
Basal cell carcinoma (BCC) is one of the most common human cancers. Most cases of BCC are amenable to surgical and topical treatments with excellent prognosis if diagnosed timely and managed appropriately. However, in a small percentage of cases, it could be locally advanced BBC (laBCC) and not amenable to surgery or radiation, including recurrent ...
Munir H, Idriss, Carolyn M, Stull, Michael R, Migden   +2 more
exaly   +3 more sources

Defining and recognising locally advanced basal cell carcinoma

European Journal of Dermatology, 2015
Rarely, basal cell carcinomas (BCCs) have the potential to become extensively invasive and destructive, a phenomenon that has led to the term "locally advanced BCC" (laBCC). We identified and described the diverse settings that could be considered "locally advanced".The panel of experts included oncodermatologists, dermatological and maxillofacial ...
Amici, J. M., Battistella, M., Beylot-Barry, M., Chatellier, A., Dalac-Ra, S., Dreno, B., Falandry, Claire, Froget, N., Giacchero, D., Grob, J. J., Guerreschir, P., Leccia, M. T., Malard, O., Mortier, L., Routier, E., Stefan, A., Stefan, D., Stoebner, P. E., Basset-Seguin, N.   +18 more
openaire   +4 more sources

Targeting the Hedgehog Pathway for Locally Advanced and Metastatic Basal Cell Carcinoma

Current Pharmaceutical Design, 2017
Basal cell caricnoma (BCC), the most common periocular magliancy, is treated with complete surgical excision. However, in patients not amenable to surgery or when surgical resection means loss of vital organs or disfiguring procedures due to locally advanced or metastatic disease, targeting the hedgehog pathway offers a novel treatment approach for ...
, Vivian T Yin
exaly   +3 more sources

Cemiplimab in locally advanced basal cell carcinoma after hedgehog inhibitor therapy: an open-label, multi-centre, single-arm, phase 2 trial [PDF]

Lancet Oncology, The, 2021
Background: Before February, 2021, there was no standard treatment regimen for locally advanced basal cell carcinoma after first-line hedgehog inhibitor (HHI) therapy.
, Aleksandar Sekulic, Oliver Bechter
exaly   +2 more sources

Identifying Locally Advanced Basal Cell Carcinoma Eligible for Treatment with Vismodegib: An Expert Panel Consensus

Future Oncology, 2015
Basal cell carcinoma (BCC) is the most common skin cancer worldwide. Most occur on the head and neck, where cosmetic and functional outcomes are critical. BCC can be locally destructive if not diagnosed early and treated appropriately.
Ketty Peris, Lisa Licitra, Paolo A Ascierto   +2 more
exaly   +2 more sources

Sonidegib: A Review in Locally Advanced Basal Cell Carcinoma

Targeted Oncology, 2016
Sonidegib (Odomzo®), an oral smoothened (SMO) antagonist, is indicated for the treatment of adults with locally advanced basal cell carcinoma (laBCC) who are not candidates for surgery or radiation therapy, or adults with recurrent laBCC following surgery or radiation therapy.
Celeste B, Burness, Lesley J, Scott
openaire   +2 more sources

Neoadjuvant vismodegib in the management of locally advanced periocular basal cell carcinoma

Eye, 2020
Vismodegib, a hedgehog pathway inhibitor, has been used in the management of locally advanced basal cell carcinoma (BCC) not suitable for surgery or radiation therapy. We report our experience using neoadjuvant vismodegib for locally advanced periocular BCC, followed by surgical excision.
David S. Curragh, Shyamala C. Huilgol, Dinesh Selva   +2 more
openaire   +2 more sources

Radiotherapy for locally advanced basal cell and squamous cell carcinomas of the skin

International Journal of Radiation Oncology*Biology*Physics, 2004
To determine the outcomes of patients with locally advanced basal cell and squamous cell carcinomas of the skin treated with radiotherapy.A retrospective review of the outcomes of patients with basal cell and squamous cell carcinomas treated with radical radiotherapy was conducted.
Winkle, Kwan, Don, Wilson, Veronika, Moravan   +2 more
openaire   +2 more sources

Complete remission of advanced, locally invasive basal cell carcinoma with vismodegib

International Journal of Oral and Maxillofacial Surgery, 2020
We report the case of a 71-year-old woman who developed advanced basal cell carcinoma (BCC) affecting the right eyebrow, invading the orbit. Globe displacement resulted in visual disturbances. Following multidisciplinary assessment, the tumour was deemed technically resectable for excision and right orbital exenteration.
P, Glen, D, Farrugia, J, Farrier
openaire   +2 more sources

Clinical and Histopathologic Characteristics of Metastatic and Locally Advanced Cutaneous Basal Cell Carcinomas

The American Journal of Dermatopathology, 2021
Abstract: Locally advanced or metastatic basal cell carcinomas (laBCCs or mBCCs) are rare, with few case series providing information on their epidemiology. We aimed to describe the clinical and histologic features of locally advanced and metastatic basal cell carcinomas.
Laura X, Baker, Erica, Grilletta, Jeffrey P, Zwerner, Alan S, Boyd, Lee, Wheless   +4 more
openaire   +2 more sources