Results 81 to 90 of about 5,418,708 (164)

Assessment methods of pathological complete response in neoadjuvant head and neck cancer clinical trials: a scoping review

The Journal of Pathology: Clinical Research, Volume 12, Issue 6, November 2026.
Abstract Head and neck cancer (HNC) trials have demonstrated pathological complete response (pCR) in patients receiving neoadjuvant treatment prior to surgery; however, systematic reviews have reported marked variation in pCR rates. This scoping review was designed to determine the definition, criteria, and assessment methodologies for pCR in ...
Peter Robinson, Charlotte Catrina Currie, Hisham Mehanna, Muhammad Shahid Iqbal, James O'Hara, Elsa Campôa, Myrto Moutafi, Max Robinson   +7 more
wiley   +1 more source

Pre-Treatment SEPTIN9 Gene Methylation Ratio Predicts Tumor Response to Total Neoadjuvant Therapy in Patients with Locally Advanced Rectal Cancer

Background and objective: Multiple markers have been proposed, but there are no reliable pre-treatment markers that predict tumor response to total neoadjuvant therapy in patients with locally advanced rectal cancer.
Héctor Guadalajara, Mariano García-Arranz, Damián García-Olmo, Luz Vega-Clemente, Víctor Domínguez-Prieto, Diana Rosero-Rodríguez, Eva Ruiz-Hispán, Raquel Fuentes-Mateos, Miguel León-Arellano, Cristina Caramés, Rocío Olivera-Salazar   +10 more
core   +1 more source

Clinical outcomes of intratumoural para‐toluenesulfonamide treatment in equine melanoma

Equine Veterinary Education, Volume 38, Issue 11, Page e821-e829, November 2026.
Summary Equine melanoma is one of the most common cutaneous neoplasms in horses and is particularly prevalent in grey horses. Although these tumours often demonstrate indolent biological behaviour, some progressively develop locally invasive or malignant characteristics over time, making treatment decisions challenging in clinical practice.
H.‐C. Lo, H. Yan‐Der, P.‐L. Chang, M.‐Y. Lin, S. Kee   +4 more
wiley   +1 more source

Direct tumour–adipocyte contact / Stroma AReactive Invasion Front Area (TAC/SARIFA) predicts adverse outcome in colorectal cancer: a focused evidence synthesis and meta‐analysis

Histopathology, Volume 89, Issue 5, Page 835-848, November 2026.
TAC/SARIFA, defined by direct tumour–adipocyte contact at the invasion front, represents a reproducible, biologically meaningful H&E biomarker with consistent adverse prognostic associations in CRC. Aims Direct tumour‐adipocyte interaction at the invasion front, termed Stroma AReactive Invasion Front Areas (SARIFA), has recently emerged as a novel H&E ...
Nic G Reitsam, Bruno Märkl, Iris D Nagtegaal, Magali Svrcek   +3 more
wiley   +1 more source

EGF61 polymorphism predicts complete pathologic response to cetuximab-based chemoradiation independent of KRAS status in locally advanced rectal cancer patients

, 2011
BACKGROUND: Cetuximab has shown significant clinical activity in metastatic colon cancer. However, cetuximab-containing neoadjuvant chemoradiation has not been shown to improve tumor response in locally advanced rectal cancer patients in recent phase I ...
Haustermans, Karin, Hu-Lieskovan, Siwen, Vallbohmer, Daniel, Semrau, Robert, Melissa J. Labonte, Zhang, Wu, Kathrin Dellas, Annelies Debucquoy, Grimminger, Peter P, Arnold, Dirk, Jean-Pascal H. Machiels, Machiels, Jean-Pascal H, Christine Sempoux, Lenz, Heinz-Josef, Daniel Vallbohmer, Wu Zhang, Peter P. Grimminger, Karin Haustermans, Dellas, Kathrin, Heinz-Josef Lenz, Yang, Dongyun, Debucquoy, Annelies, Arnulf H. Hölscher, Matej Bracko, Alexander Pohl, Pohl, Alexander, Vaneja Velenik, Sempoux, Christine, Dongyun Yang, Siwen Hu-Lieskovan, Labonte, Melissa J, Machiels, Jean-Pascal, Velenik, Vaneja, Dirk Arnold, Rödel, Claus, Hölscher, Arnulf H, Claus Rödel, Robert Semrau, Bracko, Matej, LaBonte Wilson, Melissa; id_orcid   +39 more
core   +1 more source

Feasibility of multi‐energy CT and fat fraction MRI for characterizing active bone marrow response to pelvic external beam radiation therapy

Journal of Applied Clinical Medical Physics, Volume 27, Issue 10, October 2026.
Abstract Background Pelvic external beam radiation therapy (EBRT), frequently exposes a substantial fraction of active bone marrow (ABM), leading to radiation‐induced marrow suppression and associated hematologic toxicity. Accurate delineation and quantitative assessment of ABM are therefore essential to enable marrow‐sparing radiotherapy strategies ...
Carolyn Eckrich, Kristin Bradley, Bethany Anderson, Diego Hernando, Jessica Miller, Jainil Shah, Patrick Wohlfahrt, Michael Lawless   +7 more
wiley   +1 more source

A hybrid deep learning framework for automated treatment planning in cervical cancer radiotherapy

Journal of Applied Clinical Medical Physics, Volume 27, Issue 10, October 2026.
Abstract Background Radiation therapy treatment planning is a time‐consuming trial‐and‐error process, and the plan quality is heavily dependent on planners' experiences, resulting in a strong demand for automated planning methods that can rapidly generate uniformly high‐quality plans. Purpose This study aimed to develop a hybrid automated deep learning‐
Haiyan Jiang, Zengtai Yuan, Zihao Liu, Yuxiang Wang, Wei Hu, Bing Yan, Yidong Yang   +6 more
wiley   +1 more source

Assessment of Correlation between Radiological and Pathological Response to Locally Advanced Rectal Cancer Neoadjuvant Treatment. [PDF]

, 2018
Aim: To assess the correlation between radiological and pathological response to locally advanced rectal cancer neoadjuvant treatment. Objectives: 1.
Naruševičiūtė, Neringa
core  

CONVERSION CHEMOTHERAPY FOR LOCALLY ADVANCED RECTAL CANCER: A CASE REPORT

, 2016
We present a case report of locally advanced colorectal cancer that responded successfully to conservation chemotherapy allowing R resection to be performed.
A. P. Koshel, S. V. Vtorushin, A. S. Lyakhov, К. V. Vyalova, I. V. Vikhlyanov, N. Е. Verzhbitskaya, A. Z. Azanov, О. V. Zharkova   +7 more
core   +1 more source

Dosimetric evaluation of systematic source position uncertainty along the source path and robust planning during MRI‐only cervical HDR brachytherapy

Journal of Applied Clinical Medical Physics, Volume 27, Issue 10, October 2026.
Abstract Background The knowledge of the dosimetric impact of systematic source position uncertainty and the use of a methodology for robust treatment planning against such uncertainty can help improve the quality of treatment plans, during MR‐only cervical brachytherapy treatment.
Amritpal Singh, Raffi Karshafian, Ananth Ravi, Moti Raj Paudel   +3 more
wiley   +1 more source