Results 61 to 70 of about 5,418,708 (164)

Locally Advanced Cervical Cancer in Pregnancy

, 2016
Objective Cervical cancer is the most common gynecological cancer occurring in pregnancy, creating a complex situation both for patient and physician. Neoadjuvant chemotherapy is an innovative way of managing cervical cancer in pregnancy.
Scambia, Giovanni, Ricci, Caterina, De Vincenzo, Rosa Pasqualina   +2 more
core   +1 more source

Vertical Rectus Abdominis Myocutaneous Flap Reduces Pelvic Exenteration Morbidity: A Retrospective Single‐Centre Cohort Study

ANZ Journal of Surgery, EarlyView.
ABSTRACT Background Pelvic exenteration (PE) has emerged as a viable resection strategy for locally advanced and recurrent pelvic cancers; however, it carries the burden of significant morbidity. The vertical rectus abdominis myocutaneous (VRAM) flap is a reconstructive method designed to minimise postoperative wound complications, and this study ...
Bernard Hanekom, Ranesh Palan, Aaron Rusnak, Ranjit Kunchur, Rhys Filgate   +4 more
wiley   +1 more source

Locally advanced rectal cancer [PDF]

, 2004
This thesis gives an overview of the treatment of locally advanced rectal cancer. The main focus is on neo-adjuvant treatment which aims for a decrease of tumor burden resulting in resectability. This should lead to a decreased incidence of local relapse
Reerink, Onne,, Reerink, Onne
core   +12 more sources

The use of laparoscopy for locally advanced rectal cancer

, 2018
INTRODUCTION: In the last decades, the use of minimally invasive surgery has dramatically increased for the treatment of rectal cancer. However, no clear evidence exists on the role of laparoscopy for locally advanced rectal cancer, especially for cT4 ...
Memeo, Riccardo, Martinez-Perez, Aleix, BIANCHI, GIORGIO, De'angelis, Nicola, Petrucciani, Niccolo, Brunetti, Francesco   +5 more
core   +1 more source

A Word of Caution: Watch and Wait in the Total Mesorectal Excision Era

ANZ Journal of Surgery, EarlyView.
Among 573 patients undergoing long‐course neoadjuvant chemoradiotherapy and total mesorectal excision between 2006 and 2020, five‐year overall survival was 85.7%. Local recurrence was 3.4% and metastatic recurrence was 16.5%. Pathological stage and tumour regression grade stratified long‐term outcomes, providing regional benchmarks for evaluating organ‐
K. Broughton, R. Cohen, A. Armanios, S. Jamin, E. Eguare, H. Yoo, G. Lim, E. Maclean, M. Teoh, M. Nyandoro, M. H. Wallace, J. Ryan   +11 more
wiley   +1 more source

Targeting KRAS for cancer therapy

British Journal of Pharmacology, EarlyView.
In recent years, therapeutics targeted against KRAS proto‐oncogene GTPase (KRAS)‐mutant cancers have seen significant progress. Herein we outline the biology and epidemiology of KRAS alterations at the lineage and allele levels, reviewing the clinical evidence for KRASG12C inhibition from the discovery of the recessive switch pocket to sotorasib ...
Jianlong Jia, Ruonan Liu, Tonia A. Adamide, Isis E. Fernandez, Georgios T. Stathopoulos   +4 more
wiley   +1 more source

Limitations of PIV Biomarker Analysis Related to Chemoradiotherapy and Unadjusted Confounders

Cancer Science, EarlyView.
The pan‐immune‐inflammation value (PIV) derived from four blood cell counts warrants cautious interpretation in rectal‐cancer immunotherapy, as CRT cannot be disentangled from anti‐PD‐1 effects within the small n = 16 subgroup.
Hongbo Gao, Wencai Weng
wiley   +1 more source

A pre-post test evaluation of the impact of the PELICAN MDT-TME Development Programme on the working lives of colorectal cancer team members [PDF]

, 2010
Background: the PELICAN Multidisciplinary Team Total Mesorectal Excision (MDT-TME) Development Programme aimed to improve clinical outcomes for rectal cancer by educating colorectal cancer teams in precision surgery and related aspects of ...
Collins, G., Taylor, Cath, Richardson, A., Sippitt, Joanna M., Collins, G, Ramirez, AJ, Jeremy Dawson, Ramirez Amanda J, Ramirez, A.J., Collins, Gary; id_orcid, McManus Chris, Richards, M, Alison Richardson, Ramirez, Amanda J., Collins Gary, Chris McManus, Collins, Gary, Sippitt Joanna M, Taylor, C, Richardson, A, Taylor, C., Taylor Cath, Richardson, Alison, Richards Michael, Sippitt, J.M., Michael Richards, McManus, Chris, Dawson, Jeremy, Dawson, J., Richards, Michael, Dawson Jeremy, Cath Taylor, Gary Collins, Dawson, J, Richardson Alison, McManus, C, McManus, C., Amanda J Ramirez, Sippitt, JM, Richards, M., Joanna M Sippitt, Ramirez, Amanda J, Sippitt, Joanna M   +42 more
core   +2 more sources

Squamoid Eccrine Ductal Carcinoma: Case Series of a Rare, Potentially Aggressive Skin Cancer Associated With Immunosuppression

Journal of Cutaneous Pathology, EarlyView.
ABSTRACT Squamoid Eccrine Ductal Carcinoma (SEDC) is a rare cutaneous adenexal carcinoma first described in 1997. It has distinct biphasic features on histology which commonly result in misdiagnosis as Bowen disease or cutaneous squamous cell carcinomas (cSCC) if diagnostic skin biopsies are too superficial. This may lead to a delay in diagnosis. It is
Xiang Li Tan, Pooja Patel, Jeva Cernova, Sarah Hogan, Jason Thomson, Efthymios Hadjimichael, Sharanpal Jeetle, Dorota Markiewicz, Michael Sheaff, Nilukshi Wijesuriya, Mark Hawthorne, Graeme Moir, Matthew Stodell, Kapil Bhargava, Suchitra Chinthapalli, Catherine A. Harwood   +15 more
wiley   +1 more source

Locally advanced rectal cancer: New insights for a tailored approach [PDF]

, 2020
By implementation of MRI-based staging, selective preoperative radiotherapy and surgical resection according to the TME-principle, the outcomes for patients with locally advanced rectal cancer have improved considerably over the last decades.
Valk, M.J.M. van der
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