Results 51 to 60 of about 5,418,708 (164)

Epithelial mesenchymal transition and resistance to neoadjuvant radiotherapy in locally advanced rectal cancer [PDF]

, 2014
Background: Non-response to neoadjuvant therapy is a significant challenge for clinicians managing solid cancers. This thesis aimed to determine whether Epithelial Mesenchymal Transition (EMT) was associated with non-response to neoadjuvant therapy in ...
Bhangu, Aneel
core   +1 more source

Data‐Independent Acquisition Mass Spectrometry in Tumor Classification and Cancer Biomarker Research

Mass Spectrometry Reviews, EarlyView.
Abstract Cancer treatment is far from optimal also because current classification systems do not reflect the complex molecular status of the tumor and its phenotype in sufficient detail. To construct molecular tumor classifiers, omics tools provide complex molecular data reflecting many aspects from genotype to phenotype.
Jan Simonik, Petr Lapcik, Pavla Bouchalova, Pavel Bouchal   +3 more
wiley   +1 more source

Expert consensus on clinical trial design guidelines for FLASH radiotherapy

Precision Radiation Oncology, EarlyView.
• FLASH radiotherapy has emerged as a transformative technology due to the underlying FLASH effect. • As FLASH radiotherapy moves toward clinical application, establishing standardized trial design principles is critical. • This expert consensus provides a roadmap for rigorous clinical evaluation of FLASH radiotherapy, accelerating safe translation of ...
Hui Luo, Chen Cheng, Chengliang Yang, Bing Li, Jiandong Zhang, Jinbo Yue, Zhaoyang Lou, Hui Liu, Jing Cai, Hong Ge   +9 more
wiley   +1 more source

Potential of Ginkgo biloba Extract to Intervene in Chronic Inflammation‐Related Diseases

Phytotherapy Research, EarlyView.
Chronic inflammation is a pathological mechanism underpinning many diseases. Ginkgo biloba extract (GBE) is well known for its anti‐inflammatory property. GBE and its active constituents have been shown to attenuate pro‐inflammatory cytokine production, suppress nuclear factor kappa B activation, restore redox homeostasis, and modulate disease‐relevant
Yipeng Lin, Inho Cho, Xue Zhu, Ke Wang, Ling Zhu, Wenchang Wong, Michael Murray, Fanfan Zhou   +7 more
wiley   +1 more source

Neoadjuvant chemoradiation for locally advanced rectal cancer: a systematic review of the literature with network meta-analysis

, 2019
Min Chen, Liang-zhou Chen, Lin Xu, Jin-song Zhang, Xue Song Department of General Surgery, Xiamen Hospital of Traditional Chinese Medicine, Fujian University of Traditional Chinese Medicine, Xiamen 361009, China Background: Neoadjuvant chemoradiotherapy (
Xu L, Zhang J, Chen M, Chen L, Song X
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Impact of Metformin and Diabetes on Tumor Response to Total Neoadjuvant Therapy in Advanced Rectal Cancer: A Multicenter Retrospective Cohort Study

Asia-Pacific Journal of Clinical Oncology, EarlyView.
In advanced rectal cancer patients receiving total neoadjuvant therapy (TNT), overall tumor response did not differ by diabetes status or metformin use. However, among diabetic patients, metformin use was associated with higher overall complete response rates. These findings suggest a potential benefit of metformin in enhancing TNT response in diabetic
Sergei Bedrikovetski, Mahima Raju, Tracy Fitzsimmons, Ishraq Murshed, Timothy J. Price, Michael Penniment, Sudarsha Selva‐Nayagam, Tarik Sammour   +7 more
wiley   +1 more source

Timely Delivery of Care and the Optimal Care Pathway for People With Colorectal Cancer: A Scoping Review

Asia-Pacific Journal of Clinical Oncology, EarlyView.
The “Optimal care pathway for people with colorectal cancer” is a framework designed to support clinicians delivering high‐quality, timely care to patients; however, it is unknown whether this has affected outcomes across Australia. The variable results in this review suggest that this guideline is yet to be integrated nationally. ABSTRACT The “Optimal
Elliott Benjamin Fox, Dennis Perez Castillo, Nathan Bain, Amy Brown   +3 more
wiley   +1 more source

Neoadjuvant Chemoradiation in Locally Advanced Rectal Cancer [PDF]

, 2010
BACKGROUND: At Cancer Institute, the usual protocol for locally advanced rectal cancer is neo-adjuvant chemo-radiation followed by surgery. The chemotherapy schedule used is Mitomycin-c and 5-Flurouracil concurrently with radiation.
Saritha, D
core  

Impact of RAS/RAF Mutations on Metastatic Treatment Response Following Total Neoadjuvant Therapy in Patients With Stage IV Rectal Cancer

Asia-Pacific Journal of Clinical Oncology, EarlyView.
There is limited understanding of the impact of underlying RAS/RAF mutational status on total neoadjuvant therapy metastatic tumor response rates in curative Stage IV rectal cancer patients. Complete metastatic tumor response to TNT was demonstrated in half as many mRAS as wtRAS patients and disease progression was higher in patients harboring RAS ...
Tracy R. Fitzsimmons, Z. Bunjo, E. L. Neo, A. Badiei, M. Penniment, S. Selva‐Nayagam, A. Ruszkiewicz, J. Wong, T. Sammour   +8 more
wiley   +1 more source

Gene and microRNA expression predictive of tumour response in patients treated with preoperative chemoradiotherapy for rectal cancer [PDF]

, 2013
Background Preoperative chemoradiotherapy (pCRT) followed by surgery is the standard treatment for locally advanced rectal cancer (LARC). However, the response to pCRT is not uniform, and there is no effective method to predict tumour response to pCRT ...
Maretto, I
core