Results 91 to 100 of about 1,752,389 (321)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Submodular Optimization in Location-Based Social Networks

, 2021
In recent years, with the increasing popularity and growth of social networks and mobile devices, the research on location-based social networks (LBSN) has attracted a lot of attention. As an important research topic in LBSN, submodular optimization in location-based social networks (SO-LBSN) has been considered by many studies, because it is useful in
openaire   +2 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Efficient Trajectory Prediction Using Check-In Patterns in Location-Based Social Network

Big Data and Cognitive Computing
Location-based social networks (LBSNs) leverage geo-location technologies to connect users with places, events, and other users nearby. Using GPS data, platforms like Foursquare enable users to check into locations, share their locations, and receive ...
Eman M. Bahgat, Alshaimaa Abo-alian, Sherine Rady, Tarek F. Gharib   +3 more
doaj   +1 more source

Anticipating Information Needs Based on Check-in Activity

, 2017
In this work we address the development of a smart personal assistant that is capable of anticipating a user's information needs based on a novel type of context: the person's activity inferred from her check-in records on a location-based social network.
Kiseleva J., Shokouhi M., Yang D., Yilmaz E., Zhang D.   +4 more
core   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Multi-Context Integrated Deep Neural Network Model for Next Location Prediction

IEEE Access, 2018
The prediction of next location for users in location-based social networks has become an increasing significant requirement since it can benefit both users and business.
Jianxin Liao, Tongcun Liu, Meilian Liu, Jingyu Wang, Yulong Wang, Haifeng Sun   +5 more
doaj   +1 more source