Results 81 to 90 of about 35,508,392 (286)

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

open access: yesFEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Efficient Trajectory Prediction Using Check-In Patterns in Location-Based Social Network

open access: yesBig Data and Cognitive Computing
Location-based social networks (LBSNs) leverage geo-location technologies to connect users with places, events, and other users nearby. Using GPS data, platforms like Foursquare enable users to check into locations, share their locations, and receive ...
Eman M. Bahgat   +3 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

open access: yesFEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass   +2 more
wiley   +1 more source

An agent-based retail location model on a supply chain network [PDF]

open access: yes
Clusters of business locations, which considerably impact daily activities, have been prominent phenomena. Yet the question of how and why Þrms cluster in certain areas has not been sufficiently studied.
Arthur Huang, David Levinson
core  

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

open access: yesFEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav   +2 more
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

open access: yesFEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge   +6 more
wiley   +1 more source

Investigation of Travel and Activity Patterns Using Location-based Social Network Data: A Case Study of Active Mobile Social Media Users

open access: yesISPRS International Journal of Geo-Information, 2015
Due to its relatively high availability and low cost, location-based social network (LBSN) (e.g., Foursquare) data (a popular type of volunteered geographic information) seem to be an alternative or complement to survey data in the study of travel ...
Yeran Sun, Ming Li
doaj   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

open access: yesFEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

On the use of fake sources for source location privacy : trade-offs between energy and privacy [PDF]

open access: yes, 2011
Wireless sensor networks have enabled novel applications such as monitoring, where security is invariably a requirement. One aspect of security, namely source location privacy, is becoming an increasingly important property of some wireless sensor ...
Jhumka, Arshad   +5 more
core   +1 more source

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