Results 81 to 90 of about 1,752,389 (321)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Urban Area Function Zoning Based on User Relationships in Location-Based Social Networks

open access: yesIEEE Access, 2020
With advanced development of Internet communication and ubiquitous computing, Social Networks are providing an important information channel for smart city construction.
Fei Hao   +5 more
doaj   +1 more source

Urban Regional Social Community Detection Using Location Based Social Network Big Data [PDF]

open access: yes, 2020
In this paper, we propose a methodology of applying location based social network (LBSN) Big Data to detect urban regional social communities (URSCs) and analyze their activation levels.
Jin, Hu, Piao, Gensong
core  

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Privacy Threats and Protection Recommendations for the Use of Geosocial Network Data in Research

open access: yesSocial Sciences, 2018
Inference attacks and protection measures are two sides of the same coin. Although the former aims to reveal information while the latter aims to hide it, they both increase awareness regarding the risks and threats from social media apps.
Ourania Kounadi   +2 more
doaj   +1 more source

Research on Potential Friend Recommendation Algorithm in Location-Based Social Network [PDF]

open access: yes, 2015
伴随着移动互联网技术与地理定位技术的崛起,基于位置的服务迅速地渗透到互联网的各类网站和应用中。其中,融合基于位置的服务与传统社交网络结构的位置社交网络发展迅猛,许多结合位置服务的社交类应用受到了许多互联网用户的青睐。用户在位置社交网络上分享自己的位置信息,在自己喜欢的地点进行签到,发表包含位置信息的状态和微博,通过关注周围的人寻找与自己有相同兴趣爱好的人。 随着位置社交网络应用中用户数据和地理位置数据的迅速膨胀,用户想要快速、准确地发现自己需要的信息变得越来越困难,基于位置社交网络的推荐系统开始出现 ...
李翔
core  

Your Actions Tell Where You Are: Uncovering Twitter Users in a Metropolitan Area

open access: yes, 2015
Twitter is an extremely popular social networking platform. Most Twitter users do not disclose their locations due to privacy concerns. Although inferring the location of an individual Twitter user has been extensively studied, it is still missing to ...
Sun, Jingchao   +3 more
core   +1 more source

Leveraging Personal Navigation Assistant Systems Using Automated Social Media Traffic Reporting

open access: yes, 2020
Modern urbanization is demanding smarter technologies to improve a variety of applications in intelligent transportation systems to relieve the increasing amount of vehicular traffic congestion and incidents.
Ghazzai, Hakim   +2 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

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