Results 61 to 70 of about 699,381 (334)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Network Embedding-Aware Point-of-Interest Recommendation in Location-Based Social Networks

Complexity, 2019
As one of the important techniques to explore unknown places for users, the methods that are proposed for point-of-interest (POI) recommendation have been widely studied in recent years.
Lei Guo, Haoran Jiang, Xiyu Liu, Changming Xing   +3 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

A Hybrid Approach for The Design of Facility Location and Supply Chain Network Under Supply and Demand Uncertainty: A Systematic Review [PDF]

, 2009
In today’s extremely competitive marketplace, firms are facing the need to meet or exceed increasing customer expectations while cutting costs to stay competitive in a global market. To develop competitive advantage in this business climate, companies
Meeyai, Sutthipong
core  

Location privacy preserving scheme against attack from friends in SNS

Tongxin xuebao, 2016
In order to enrich the performance of the user's location information and to meet the diverse needs of users,a location privacy protection scheme based on attribute encryption was designed,which provided precise,more accurate,fuzzy and private four modes
Xi LIN, Yi-liang HAN, Yan KE, Xiao-yuan YANG   +3 more
doaj   +2 more sources

Spectral clustering and embedding-enhanced POI recommendation in location-based social network

Tongxin xuebao, 2020
In order to effectively capture the spatial characteristics of multi-dimensional context information in LBSN,and deeply explore the non-linear interaction between users and POIs,a spectral embedding enhanced POI recommendation algorithm,namely PSC-SMLP ...
Zhen LIU, Na’na WANG, Xiaodong WANG, Yongqi SUN   +3 more
doaj   +2 more sources

A Point-of-Interest Recommendation Method Exploiting Sequential, Category and Geographical Influence

ISPRS International Journal of Geo-Information, 2022
Point of interest (POI) recommendation as an important service in location-based social networks has developed rapidly, which can help users find more interesting unknown locations and facilitate service providers to provide users with more accurate ...
Xican Wang, Yanheng Liu, Xu Zhou, Xueying Wang, Zhaoqi Leng   +4 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source