Results 101 to 110 of about 1,114,000 (268)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Remote device access in the new accelerator controls middleware [PDF]

, 2001
This paper presents the Remote Device Access (RDA) package developed at CERN in the framework of the joint PS/SL Controls Middleware project. The package design reflects the Accelerator Device Model in which devices, named entities in the control system,
Baggiolini, V, Di Maio, F, Jensen, S, Kostro, K, Risso, A, Trofimov, N N   +5 more
core  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Targeting the Cellular Prion Protein as a Biomarker for Stem Cells, Cancer, and Regeneration

Biologics
The cellular prion protein (PrPC) displays a functional repertoire that extends well beyond its classical link to transmissible spongiform encephalopathies.
Niccolò Candelise, Nicola Salvatore Orefice, Elisabetta Mantuano, Stefano Martellucci   +3 more
doaj   +1 more source

Turbulence and transition modeling for high-speed flows [PDF]

Research conducted during the past three and a half years aimed at developing and testing a turbulence/transition model applicable to high-speed turbulent flows is summarized.
Wilcox, David C.
core   +1 more source

Circular Economy Snapshot: BMW Drivenow [PDF]

, 2015
BMW's views of the future of car ownership influenced its decision to enter the car-sharing business. DriveNow estimates that an average car is used only about 4% of the time and with half the global population predicted to live in cities by 2050 and ...

core  

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Attitude control system [PDF]

, 1976
An attitude control system is described in which angular rate signals are generated by rate gyros mounted closely adjacent to gimbaled engines at the rear of a vehicle.
Rupp, C. C., Vonpragenau, G. L.
core   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

DIP: Disruption-Tolerance for IP [PDF]

, 2010
Disruption Tolerant Networks (DTN) have been a popular subject of recent research and development. These networks are characterized by frequent, lengthy outages and a lack of contemporaneous end-to-end paths.
Neufeld, Michael
core