Results 111 to 120 of about 1,114,000 (268)
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Valve recession: From experiment to predictive model
, 2004 Increasing demands on engine performance and cost reductions have meant that advances made in materials and production technology are often outpaced This frequently results in wear problems occurring with engine components.
Brooks, A. +3 more
core
Location Independent Manufacturing – A Software Solution for Supply Chains
Procedia Manufacturing, 2017 Abstract One possible solution to the challenges of globalization, sustainability and the upcoming megatrends is the Location Independent Manufacturing (LIM) concept. The LIM concept is a new manufacturing philosophy that has gotten the attention of Finnish SMEs.
Merja Peltokoski +2 more
openaire +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Sequential Estimation of a Common Location Parameter of two Populations
Revstat Statistical Journal, 2016 The problem of sequentially estimating a common location parameter of two independent populations from the same distribution with an unknown location parameter and known but different scale parameters is considered in the case when the observations ...
Agnieszka Stępień-Baran
doaj +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Scheduling concurrent rpcs in the globe location service [PDF]
, 1997 Globe is a wide-area distributed system in which an object can be located through its location-independent identifier. This is done by means of a worldwide location service.
Ballintijn, G.C. +2 more
core +2 more sources
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
The GLASS project: supporting secure shibboleth-based single sign-on to campus resources [PDF]
, 2007 Higher and Further education institutions in the UK are in the process of migrating their IT infrastructures to exploit Shibboleth technologies for federated access management. Ease of use and secure access are paramount to the successful uptake of these
Jiang, J., Sinnott, R.O., Watt, J.
core +2 more sources
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source