Results 91 to 100 of about 3,756,771 (293)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
On Idempotent Estimators of Location [PDF]
Idempotence is a well-known property of functionals of location. It means that the value of the functional at a singular distribution must be identically to the mass point of this distribution.
Klein, Ingo
core
A High Performance Privacy-Oriented Location System [PDF]
, 2003 Many mobile applications can be greatly enhanced when provided with the locations of people and devices. Ultrasonic location systems have been shown to supply location information with centimeter accuracy at high update rates.
Ward, Andy, Hazas, Michael
core
Trials, 2019 Background A disturbance in the early colonisation of the gut by microorganisms is associated with an aberrant innate immune system and a variety of clinical conditions later in life. Several factors are considered to influence this initial colonisation,
Thomas H. Dierikx +7 more
doaj +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
Optimization of ambulance location model using maximal coverage location problem and gradual coverage location problem [PDF]
, 2014 Emergency Medical Services (EMS) in Malaysia was categorized as underdeveloped emergency care system in 1990s. This was due to the lack of specialty in emergency medical systems and academic activities.
Wan Md. Hatta, Wan Ahmad Lutfi
core
DNA repair: Location, location, location
Oncotarget, 2015 DNA double strand breaks (DSBs) are the most dangerous form of DNA damage and need to be repaired efficiently in order to maintain genomic stability. The kinase ATM becomes activated upon recognition of DSBs and transduces this into cell cycle checkpoint activation and DNA repair.
van Sluis, Marjolein, McStay, Brian
openaire +3 more sources
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source