Results 131 to 140 of about 3,756,771 (293)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

open access: yesFEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Devising a Corporate Facility Location Strategy to Maximize Shareholder Wealth [PDF]

open access: yes
Location decisions should consider all related impacts upon a firm’s shareholder wealth. Overall, firm cost savings available at alternative locations need to be carefully examined in addition to a location’s impact on corporate sales revenues.
Mauricio Rodriguez   +2 more
core  

Location Referencing System Team Report, Final Report, January 15, 1998 [PDF]

open access: yes, 1998
This report is a culmination of the Location Referencing System (LRS) team. The team was charged with defining a system that coordinates the collection storage, and access to location referencing information by developing an LRS to be used throughout the

core  

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

International Taxation and Multinational Firm Location Decisions [PDF]

open access: yes
Using a large international firm-level data set, we estimate separate effects of host and parent country taxation on the location decisions of multinational firms.
Salvador Barrios   +3 more
core  

Exclusivity and memory for object location [PDF]

open access: yes, 2010
Baguley et al. (2006) have demonstrated that location memories are retrieved exclusively: when a person has two or more memories for an object’s location (which show the same object from different perspectives), only one representation can be retrieved ...
Clark, DPA
core  

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

open access: yesFEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi   +6 more
wiley   +1 more source

Location-Based Mobile Marketing Innovations 2018 [PDF]

open access: yes, 2019
The increasing complexity of the industry means that marketers must now be experts not only in marketing, but also in people, data, delivery platforms, and mobile location-based marketing.
Yim, J (15773000)   +2 more
core  

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