Results 121 to 130 of about 3,756,771 (293)
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
TREM2 risk variants and associated endophenotypes in alzheimer’s disease
Alzheimer’s Research & TherapyBackground Rare variants of the triggering receptor expressed on myeloid cell 2 (TREM2) gene are strong risk factors for Alzheimer’s disease (AD), and drugs targeting the TREM2 protein are being developed.
Janna I. R. Dijkstra +19 more
doaj +1 more source
α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates
FEBS Letters, EarlyView.Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino +2 more
wiley +1 more source
Pollution Taxes and Location Decision under Free Entry Oligopoly [PDF]
This paper examines the impact of a pollution tax as a pollution control device on the output and location decisions of undifferentiated oligopolistic firms with free entry.
Hsin-I Fan, Yeung-Nan Shieh
core
Melaka Tourism Location Based Service [PDF]
, 2011 This paper presents a Location Based Service framework application deployed in Melaka urban area. The Melaka Tourism Location Base Service is delivered to support tourist activity to find any nearby venue around their current location.
Dr. Luqman Ibnu Purnomo
core +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Learning from Location Histories for Context-aware Location Recommendations in LBS [PDF]
, 2013 Location recommendation is one of the most important components in many Location Based Services (LBS), especially in mobile guides. Currently, providing context-aware location (e.g., Point of Interest, POI) recommendations is still very challenging. This
Huang, Haosheng, Gartner, Georg
core
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
LBWiki: A Location-Based Wiki [PDF]
, 2008 Wiki systems provide a simple interface paradigm that allow non-technical users to author collaborative on-line hypertexts. In this paper we propose to use the same simple paradigm to allow users to create content for ubiquitous information systems, and ...
Lewis, Rebecca +2 more
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