Results 141 to 150 of about 3,756,771 (293)

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Economic integration and location of manufacturing activities: Evidence from MERCOSUR [PDF]

open access: yes
Economic integration leads to a reallocation of resources across sectors and space. Location patterns resulting from North-North and North-South regional trade initiatives have been documented in several studies.
Traistaru, Iulia   +2 more
core  

Economic location-based services, privacy and the relationship to identity [PDF]

open access: yes, 2005
Mobile telephony and mobile internet are driving a new application paradigm: location-based services (LBS). Based on a person’s location and context, personalized applications can be deployed.
Fritsch, Lothar
core  

Accelerated intermittent theta burst stimulation in bipolar depression: a pilot study

open access: yesBrain Stimulation
Urmi Pahladsingh   +4 more
doaj   +3 more sources

Effect of brain target and stimulation paradigm on response to deep brain stimulation in obsessive-compulsive disorder

open access: yesBrain Stimulation, 2021
Ilse Graat   +6 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

The location of European industry [PDF]

open access: yes
The objectives of this study are to describe the changes in industrial location that have occured in Europe in recent decades; to establish whether these are associated with countries' economic structures becoming more or less similar, and industries ...
K.H. Midelfart   +3 more
core  

Concurrent Intracranial and Extracranial Electrophysiological Recordings in Humans: relevance for deep brain stimulation in psychiatric disorders

open access: yesBrain Stimulation, 2021
D. Denys   +9 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

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