Results 111 to 120 of about 127,551 (298)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Activity-based and Behavior-based Location Recommendation in Location Based Social Networks
, 2014 Location-Based Social Networks (LBSNs) are social networks with functionalities that let users share their location information with other users. Location recommendation is the task of suggesting unvisited locations to the users.
Rahimi, Seyyed Mohammadreza
core +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Using Social Network Data and Space Syntax Analyses for Developing Urban Strategies: Kadıköy Case
Megaron, 2019 Cities are dynamic systems; consist of physical and social networks which interact each other constantly. In this age, an emergent term: Big Data -which is generated with activities that are taken shape in cities integrated with information technologies-
Taner Üsküplü, Birgül Çolakoğlu
doaj +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Frontiers in Sustainable CitiesPoint-of-interest (POI) recommendation is one of the primary tasks of location-based social networks (LBSNs). With user data in bulk, extracting useful information and addressing issues such as data sparsity and cold-start problems looming large in ...
Malika Acharya, Krishna Kumar Mohbey
doaj +1 more source
Towards Understanding Location Privacy Awareness on Geo-Social Networks
ISPRS International Journal of Geo-Information, 2017 Users' awareness of the extent of information implicit in their geo-profiles on social networks is limited. This questions the validity of their consent to the collection, storage and use of their data.
Alia I. Abdelmoty, Fatma Alrayes
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source