Results 101 to 110 of about 7,497 (294)
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
The syntax of locative inversion: The preverbal locative NP in lexical functional grammar
, 2007 Locative inversion construction in Setswana, as in other Bantu languages, defies straightforward analysis in the sense that the preverbal locative NP does not pass the subject hood test, while the post-verbal NP shows features atypical of objects. In the
Morapedi, S, S Morapedi
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Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
A corpus-based description of locative and non-locative reference in Kirundi locative enclitics
This article presents a corpus-based description of locative as well as non‑locative functions of Kirundi locative enclitics. Whereas locative verbal prefixes in Kirundi are restricted to class 16, one of four locative enclitics (class 16, 17, 18 &
Bostoen, K., Devos, M., Misago, M-J.
core
, 2004 Locative media uses portable, networked, location aware computing devices for user-led mapping and artistic interventions in which geographical space becomes its canvas.
Hemment, Drew
core
A Corpus-based Description of Locative and Non-locative Reference in Kirundi Locative Enclitics
Africana Linguistica, 2017 Devos, Maud +2 more
openaire +2 more sources
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
A pragmatic explanation of the stage level/individual level contrast in combination with locatives
, 2004 One important difference between stage level predicates (SLPs) and individual level predicates (ILPs) is their behavior with respect to locative modifiers. It is commonly assumed that SLPs but not ILPs combine with locatives.
Maienborn, Claudia
core
Locative relatives in Durban Zulu
, 2010 This paper examines locative relatives in Durban Zulu. We show that locative relatives differ from nominal relatives crucially in prosodic phrasing as well as in resumptive pronoun marking.
Cheng, Lisa L.-S. +3 more
core +1 more source