Results 131 to 140 of about 7,497 (294)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Compensation et garantie locative

open access: yes, 2019
Deux décisions de jurisprudence ont permis de revenir sur les questions du privilège que détient éventuellement le bailleur sur la garantie locative et sur la possible compensation de la garantie ...
Toussaint, Albane
core  

Locative inversion and agreement syntax in Brazilian Portuguese

open access: yesMatraga, 2009
Adopting the Minimalist Program framework (CHOMSKY 2000, 2001), this paper suggests that, in Brazilian Portuguese, sentences with a locative prepositional phrase in preverbal position can be characterized as instances of locative inversion in which ...
Juanito Ornelas de Avelar
doaj  

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

open access: yesMolecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou   +12 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

open access: yesMolecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi   +7 more
wiley   +1 more source

Locative Inversion:A Comparative Study of English and Chinese

open access: yes, 2007
本篇論文主在討論英語與漢語存在句(locative inversion)的動詞。旨在找出動詞在存在句中出現的正確必要的語意條件。 一般的論述認為,存在句裡面出現的動詞都是非受格動詞(unaccusative verb),然而,我的分析是,除了典型的非受格動詞之外,一些非作格動詞(unergative verb)也有在英語存在句裡出現,而且非受格狀態變化動詞(verbs of change of state)是不能出現在存在句中的。借用衍生詞彙(The Generative Lexicon ...
菊島和紀, Kikushima, Kazunori
core  

Making Sense of Audiowalks: Methodological Considerations for the Study of Locative Media

open access: yes
This article discusses audiowalks as mobile locative media and raises issues around how to analyze such hybrid and situated aesthetic and narrative experiences. We employ sensory ethnographies coupled with post-phenomenological concepts to present a mode
Engberg, Maria   +1 more
core   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

open access: yesMolecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen   +14 more
wiley   +1 more source

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