Results 51 to 60 of about 12,400 (292)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Embodied memory and curatorship in children’s digital video production [PDF]

open access: yes, 2010
Digital video production in schools is often theorised, researched and written about in two ways: either as a part of media studies practice or as a technological innovation, bringing new, “creative”, digital tools into the curriculum.
Potter, John
core   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Book review: smartphones as locative media [PDF]

open access: yes, 2015
How do location-based services impact social life and reconfigure interpretations of physical spaces? In Smartphones as Locative Media, the author maintains that physical spaces are differentially experienced by people if digital information is accessed ...
Polonski, Vyacheslav
core  

Locative Media as Remix [PDF]

open access: yes, 2014
While data-driven art is not new, recent developments in technical, artistic, and social spheres have coalesced to produce new opportunities for artists and activists who remix data with space and place to form locationally specific political critiques of great power and flexibility.
openaire   +2 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

You are here. Prolegomena for a geolocated literature.

open access: yesHybrid, 2018
If the advent and the mass spread of smartphones and other mobile devices have already been the subject of several studies, particularly in the fields of cognitive science and sociology, literary analysis in this regard remains somewhat rare, especially ...
Enrico Agostini Marchese
doaj   +1 more source

Notes for walking an augmented landscape : spatial narrative, walked practices and locative technologies [PDF]

open access: yes, 2014
University of Technology, Sydney. Faculty of Arts and Social Sciences.Since the early 2000s, media artists have explored the area of location awareness through diverse locative media projects in which geographical space acts as an interface for artistic ...
Heyward, ME
core  

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

STAK – Serendipitous tool for augmenting knowledge: A conceptual tool for bridging digital and physical resources

open access: yesDigital Studies, 2017
Humanities scholars have long claimed the importance of browsing in the library stacks as part of their research process. The digitization practices of libraries and archives, while meant to assist with preservation and access, make the physical browsing
Anabel Quan-Haase   +2 more
doaj   +1 more source

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