Results 51 to 60 of about 276,614 (300)
Via@The concepts of transition, transformation, tipping points, and resilience have gained currency in recent years given the impacts of crisis events on tourism.
C. Michael Hall
doaj +1 more source
Journal of Fluid Science and Technology, 2017 This study examines experimentally the vortex-induced vibration (VIV) of a mechanical system with two eigenmodes. A previous experiment setup was refined to enable the experiment, and was placed in a circulating water channel to submerge a movable ...
Yoshiki NISHI, Komei SAITOH
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Infrared Lock-in Thermography Tests with Optical Feedback
U.Porto Journal of Engineering, 2022 Thermography using a period light stimulation. However, the results are highly dependent on the accuracy of the stimulation source and its dynamic response.
António José Ramos Silva +3 more
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Carbon Lock-In: The Role of Expectations [PDF]
SSRN Electronic Journal, 2014 AbstractWe argue that expectations about future energy use affect the transition from fossil to renewables because of an interaction between innovation and resource scarcity. This article presents a model of directed technical change to study this interaction.
Gerard van der Meijden, Sjak Smulders
openaire +6 more sources
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Disrupting the status quo: a sustainability transitions analysis of the fashion system
Sustainability: Science, Practice, & Policy, 2022 The fashion industry has developed into a complex global system with persistent social and environmental sustainability challenges. Private, public, and civil society actors have condemned these persistent problems and called for system change toward ...
Sophie Buchel +3 more
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Transformation Locked in a Loop [PDF]
Cell, 2009 During neoplastic transformation, cells can promote their own growth by activating proto-oncogenes. Reporting in Cell, Iliopoulos et al. (2009) now show that in certain cell types, a transient oncogenic signal is sufficient to induce neoplastic transformation and to maintain it through a positive feedback loop driven by the inflammatory cytokine ...
Drost J, Agami R.
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Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Pulses for Sustainability: Breaking Agriculture and Food Sectors Out of Lock-In
Frontiers in Sustainable Food Systems, 2018 Crop diversification can improve the sustainability of Western agriculture. In particular, pulses are crops that can help both agriculture and the food industry become more ecological, as they reduce greenhouse gas emissions and help reduce animal-based ...
Marie-Benoit Magrini +8 more
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Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source