Results 41 to 50 of about 1,823,579 (281)
Augmented base loci and restricted volumes on normal varieties
, 2014 We extend to normal projective varieties defined over an arbitrary algebraically closed field a result of Ein, Lazarsfeld, Musta\c{t}\u{a}, Nakamaye and Popa characterizing the augmented base locus (aka non-ample locus) of a line bundle on a smooth ...
Boucksom, Sébastien +2 more
core +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Glocalism: Journal of Culture, Politics and InnovationThe United Nations Climate Dictionary states that “climate change is the defining issue of our times”. According to this Dictionary, we are facing a global crisis which “refers to the serious problems that are being caused, or are likely to be caused ...
GLOCALISM
doaj +1 more source
Integration of circadian and hypoxia signaling via non‐canonical heterodimerization
FEBS Letters, EarlyView.CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley +1 more source
BRIDGING THE GAP: GLOCAL TENSIONS AND GEOPOLITICAL ORDER
Glocalism: Journal of Culture, Politics and InnovationA critical feature of our interconnected world seems particularly relevant nowadays: the inherent tension between glocal reality and a rigid geopolitical order.
GLOCALISM
doaj +1 more source
Simultaneous Border-Collision and Period-Doubling Bifurcations
, 2009 We unfold the codimension-two simultaneous occurrence of a border-collision bifurcation and a period-doubling bifurcation for a general piecewise-smooth, continuous map.
Angulo F. +7 more
core +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
WELL-BEING: THREATS AND ACHIEVEMENTS
Glocalism: Journal of Culture, Politics and InnovationWere one to be asked to think about well-being, his or her mind would probably wander among images of harmony, happiness or satisfaction. Others might focus on physical health, conjecture on the achievement of personal goals or conceive of well-being by
GLOCALISM
doaj +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source