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Molecular control of locus coeruleus neurotransmission
Biological Psychiatry, 1999The locus coeruleus (LC) is the major noradrenergic nucleus in the brain and innervates large segments of the neuraxis. LC neurons are thought to regulate states of attention and vigilance as well as activity of the sympathetic nervous system. These neurons also have been implicated in the actions of stress, antidepressants, and opiates on the brain ...
E J, Nestler, M, Alreja, G K, Aghajanian
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The role of the locus coeruleus
Trends in Neurosciences, 1979170 fathers can only be a maximum of 10 times higherB: the high carrier detection rate obtained in the mothers by Biggs and Rizza would also be evidence against such a possibility. The results of Frank and his colleagues for carriers of the Lesch-Nyhan syndrome could be explained by the presence of heterozygote advantage, but the authors reject this ...
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1984
The nucleus locus coeruleus (LC) is a group of neurons situated close to the floor of the fourth ventricle at the upper border of the pons. The cells of the rat LC are homogeneous by certain criteria. Virtually all the cells contain noradrenaline and its synthesizing enzymes (Dahlstrom and Fuxe, 1964; Pickel et al., 1979), and, in the anesthetized ...
John Williams +2 more
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The nucleus locus coeruleus (LC) is a group of neurons situated close to the floor of the fourth ventricle at the upper border of the pons. The cells of the rat LC are homogeneous by certain criteria. Virtually all the cells contain noradrenaline and its synthesizing enzymes (Dahlstrom and Fuxe, 1964; Pickel et al., 1979), and, in the anesthetized ...
John Williams +2 more
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Raphe projections to the locus coeruleus in the rat
Brain Research Bulletin, 1979Afferent projections to the locus coeruleus from the various raphe nuclei, particularly of the midbrain (nuclei raphe dorsalis and medianus) and pons (nuclei raphe pontis and magnus), have been studied in the rat by retrograde transport methods using horseradish peroxidase (HRP). The locus coeruleus, in both its dorsomedial and ventrolateral divisions,
P J, Morgane, M S, Jacobs
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Iontophoretic application of opiates to the locus coeruleus
Brain Research, 1977The vast majority of morphine-sensitive single units in the area examined were localized to the locus coeruleus. This corresponds well with the known distribution of the highest densities of opiate receptor sites in this region of the midbrain. The effect of iontophoretically applied morphine was a marked and prolonged depression of spontaneous ...
S J, Bird, M J, Kuhar
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Polymorphic computation in locus coeruleus networks
Nature Neuroscience, 2017Physiological and optogenetic dissection of discrete locus coeruleus neuronal populations reveals a functional disassociation, with heterogeneous engagement of locus coeruleus neurons in either fear learning or extinction models.
Dong-Oh, Seo, Michael R, Bruchas
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Responses of locus coeruleus neurons to neuropeptides
1991The knowledge on the neuronal inputs to the locus coeruleus (LC) and their roles in regulating noradrenergic (NA) cellular activity is quite advanced. In recent years, however, about ten neuropeptides were found to be localized in the area of the rodent LC; peptides which may be considered as potential transmitters or modulators acting in this area ...
H R, Olpe, M, Steinmann
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