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Locus coeruleus imaging as a biomarker for noradrenergic dysfunction in neurodegenerative diseases [PDF]
Brain, 2019 Pathological alterations to the locus coeruleus, the major source of noradrenaline in the brain, are histologically evident in early stages of neurodegenerative diseases.
Matthew J Betts +2 more
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European Journal of Pharmacology, 2002 The interaction between the locus coeruleus and dorsal raphe nucleus was investigated by means of dual-probe microdialysis in conscious rats. The release of noradrenaline and 5-hydroxytryptamine (5-HT) after inhibition or stimulation of locus cocruleus ...
Thomas I F H Cremers, Ben H C Westerink
exaly +2 more sources
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Cell and Tissue Research, 2017
The locus coeruleus (LC) contains norepinephrine (NE)-synthesizing neurons that send diffuse projections throughout the central nervous system. The LC-NE system has a major role in arousal, attention and stress responses. In the brain, NE may also contribute to long-term synaptic plasticity, pain modulation, motor control, energy homeostasis and ...
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The locus coeruleus (LC) contains norepinephrine (NE)-synthesizing neurons that send diffuse projections throughout the central nervous system. The LC-NE system has a major role in arousal, attention and stress responses. In the brain, NE may also contribute to long-term synaptic plasticity, pain modulation, motor control, energy homeostasis and ...
openaire +2 more sources
Journal of Chemical Neuroanatomy, 2000
The author outlines the history of the locus coeruleus from its discovery to the latest research findings. Although Russel's report in Texas has been believed to be the first break-through scientific article of this neuronal structure, there were two preceding, anatomical and physiological, studies made by Japanese groups.
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The author outlines the history of the locus coeruleus from its discovery to the latest research findings. Although Russel's report in Texas has been believed to be the first break-through scientific article of this neuronal structure, there were two preceding, anatomical and physiological, studies made by Japanese groups.
openaire +2 more sources
Response of the locus coeruleus to asphyxia
Bulletin of Experimental Biology and Medicine, 1977To ascertain the mechanisms of the locus coeruleus (LC) function the response of the locus coeruleus neurons to the experimental sharp asphyxia was investigated by the light and electron microscope techniques. Apart from the specific nervous effect (directly through the LC axons and through the stem reticular formation), LC produced humoral influence ...
T I, Belova, M A, Pal'tsev
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Opioid Inhibition in Locus Coeruleus
Journal of Neurophysiology, 19951. Inhibition of locus coeruleus (LC) neurons by opioids is mediated by hyperpolarization associated with an increase in potassium conductance. However, opioids caused an outward current even at potentials more negative than the potassium equilibrium potential in the majority of LC neurons recorded in brain slices cut in the horizontal plane. 2.
R A, Travagli +2 more
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Release of neurotransmitters in the locus coeruleus
Progress in Neurobiology, 1998In the past 15 years the release of neurotransmitters and their metabolites in the locus coeruleus (LC) has been studied by using three approaches: microdialysis; push-pull superfusion; and voltammetry. These sophisticated techniques, which render it possible to follow the time course and magnitude of neurochemical changes in anaesthetized and ...
N, Singewald, A, Philippu
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The human locus coeruleus and anxiogenesis
Brain Research, 1994Electrical stimulation of locus coeruleus (LC), via permanently implanted electrodes with confirmed localization and effectiveness, did not elicit any subjective or behavioral manifestations of anxiety. This is evidence against the hypothesis that LC is a mediator of anxiogenesis in man.
B, Libet, C A, Gleason
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