Results 1 to 10 of about 138,491 (253)

Astrocytes, Noradrenaline, α1-Adrenoreceptors, and Neuromodulation: Evidence and Unanswered Questions

Frontiers in Cellular Neuroscience, 2021
Noradrenaline is a major neuromodulator in the central nervous system (CNS). It is released from varicosities on neuronal efferents, which originate principally from the main noradrenergic nuclei of the brain – the locus coeruleus – and spread throughout
Jérôme Wahis, Matthew G Holt
exaly   +3 more sources

Impact of noradrenaline, adrenergic receptors, and radical formation on cardiac mitochondria in resuscitated swine [PDF]

Intensive Care Medicine Experimental
Background Equivocal data exist on whether noradrenaline during resuscitation from circulatory shock affects tissue mitochondrial respiration. Therefore, we examined the relation between myocardial mitochondrial respiration and plasma noradrenaline ...
Nadja Abele, Tamara Merz, Fabian Zink, Andrea Hoffmann, Michael Gröger, Sandra Kress, Stefanie Kranz, Andrea Seifritz, Vittoria Passarelli, Franziska Münz, Maximilian Feth, Magnus Scheer, Ohad Sharon, Melanie Hogg, Eva-Maria Wolfschmitt, Ulrich Wachter, Tanja Schulz, Enrico Calzia, Nicolas Fage, Christiane Waller, Pierre Asfar, Peter Radermacher, Thomas Kapapa   +22 more
doaj   +2 more sources

Involvement of P2Y₁, P2Y₆, A₁ and A_2A Receptors in the Purinergic Inhibition of NMDA-Evoked Noradrenaline Release in the Rat Brain Cortex

Cells, 2023
In the cerebral cortex, glutamate activates NMDA receptors (NMDARs), localized in noradrenergic neurons, inducing noradrenaline release that may have a permissive effect on glutamatergic transmission, and therefore, on the modulation of long-term ...
Clara Quintas, Jorge Gonçalves, Glória Queiroz   +2 more
doaj   +1 more source

Noradrenaline transporter PET reflects neurotoxin-induced noradrenaline level decrease in the rat hippocampus

EJNMMI Research, 2023
Background The neuropathological changes of early Alzheimer’s disease (AD) include neurodegenerative loss of noradrenaline neurons in the locus coeruleus with decreasing noradrenaline availability in their projection areas such as the hippocampus.
Takayuki Sakai, Saori Hattori, Aya Ogata, Takashi Yamada, Junichiro Abe, Hiroshi Ikenuma, Masanori Ichise, Masaaki Suzuki, Kengo Ito, Takashi Kato, Yasuyuki Kimura   +10 more
doaj   +1 more source

Effect of Noradrenaline on the Facial Stimulation-Evoked Mossy Fiber-Granule Cell Synaptic Transmission in Mouse Cerebellar Cortex

Frontiers in Neuroscience, 2021
Noradrenaline is an important neuromodulator in the cerebellum. We previously found that noradrenaline depressed cerebellar Purkinje cell activity and climbing fiber–Purkinje cell synaptic transmission in vivo in mice.
Bing-Xue Li, Bing-Xue Li, Hua Jin, Hua Jin, Guang-Jian Zhang, Guang-Jian Zhang, Li-Na Cui, Li-Na Cui, Chun-Ping Chu, Chun-Ping Chu, De-Lai Qiu, De-Lai Qiu   +11 more
doaj   +1 more source

Connective tissue mast cells store and release noradrenaline

Journal of Physiological Sciences, 2023
Mast cells are present in mucosal and connective tissues throughout the body. They synthesize and release a wide variety of bioactive molecules, such as histamine, proteases, and cytokines.
Yusuke Otani, Soichiro Yoshikawa, Kei Nagao, Takehiro Tanaka, Shinichi Toyooka, Atsushi Fujimura   +5 more
doaj   +1 more source

Hippocampal seizures differentially modulate locus coeruleus activity and result in consistent time-locked release of noradrenaline in rat hippocampus

Neurobiology of Disease, 2023
The locus coeruleus (LC) is a small brainstem nucleus and is the sole source of noradrenaline in the neocortex, hippocampus and cerebellum. Noradrenaline is a powerful neuromodulator involved in the regulation of excitability and plasticity of large ...
Lars Emil Larsen, Sielke Caestecker, Latoya Stevens, Pieter van Mierlo, Evelien Carrette, Paul Boon, Kristl Vonck, Robrecht Raedt   +7 more
doaj   +1 more source

Diagnostic values of noradrenaline administered dose, procalcitonin (PCT) and blood lactic acid for septic shock [PDF]

Journal of Medical Biochemistry
Background: Sepsis/septic shock is a life-threatening condition that requires prompt and effective treatment. Noradrenaline is a widely used vasopressor to manage septic shock, but its optimal dosage remains unclear.
Ding Lili, Liu Mengru, Sun Haijun
doaj   +1 more source

Differences in Noradrenaline Receptor Expression Across Different Neuronal Subtypes in Macaque Frontal Eye Field

Frontiers in Neuroanatomy, 2020
Cognitive functions such as attention and working memory are modulated by noradrenaline receptors in the prefrontal cortex (PFC). The frontal eye field (FEF) has been shown to play an important role in visual spatial attention.
Max Lee, Adrienne Mueller, Tirin Moore, Tirin Moore   +3 more
doaj   +1 more source

Effect of noradrenaline on propofol-induced mitochondrial dysfunction in human skeletal muscle cells

Intensive Care Medicine Experimental, 2022
Background Mitochondrial dysfunction is a hallmark of both critical illness and propofol infusion syndrome and its severity seems to be proportional to the doses of noradrenaline, which patients are receiving.
Adéla Krajčová, Christine Skagen, Valér Džupa, Tomáš Urban, Arild C. Rustan, Kateřina Jiroutková, Bohumil Bakalář, G. Hege Thoresen, František Duška   +8 more
doaj   +1 more source