Results 1 to 10 of about 380,424 (246)
Locus coeruleus pathology in progressive supranuclear palsy, and its relation to disease severity
Acta Neuropathologica Communications, 2020 The locus coeruleus is the major source of noradrenaline to the brain and contributes to a wide range of physiological and cognitive functions including arousal, attention, autonomic control, and adaptive behaviour.
Sanne Simone Kaalund +6 more
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Locus coeruleus features are linked to vagus nerve stimulation response in drug-resistant epilepsy
Frontiers in NeuroscienceThe locus coeruleus–norepinephrine system is thought to be involved in the clinical effects of vagus nerve stimulation. This system is known to prevent seizure development and induce long-term plastic changes, particularly with the release of ...
Alexandre Berger +20 more
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The involvement of the locus coeruleus in memory
Behavioral and Neural Biology, 1981 The effects on memory of electrolytic lesions in the locus coeruleus complex (LC) were investigated in three experiments using Swiss mice. Forebrain norepinephrine (NE) levels and histological analysis of lesion sites were used to verify lesion adequacy.
Department of Neuroscience, College of Medicine, University of Florida, Gainesville, Florida 32610, USA ( host institution ) +2 more
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Nature Communications, 2022 Older individuals exhibiting diminished function of the locus coeruleus while learning new information show faster cognitive decline that is typical for Alzheimer’s disease.
Prokopis C. Prokopiou +13 more
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Otorhinolaryngology and Facial Plastic Surgery, 2017 Background: Neurodegeneration in the locus coeruleus (LC) has been documented in several central nervous system (CNS) neurodegenerative diseases and sleep deprivation.
Somaye Mesgar +5 more
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Locus coeruleus and labile memory
Pharmacology Biochemistry and Behavior, 1978 Abstract Memory lability is defined as the period of time recently-formed memory remains susceptible to experimental modification. Electrolytic lesions delivered through chronic indwelling electrodes to the locus coeruleus (LC) complex of mice, made shortly after learning, resulted in an extension of memory lability.
Department of Neuroscience, College of Medicine, University of Florida Gainesville, FL 32610, USA ( host institution ) +3 more
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Molecular Pain, 2017 N-acetylaspartylglutamate (NAAG) is the third most prevalent and widely distributed neurotransmitter in the mammalian nervous system. NAAG activates a group II metabotropic glutamate receptor (mGluR3) and is inactivated by an extracellular enzyme ...
Takahiro Nonaka +6 more
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Locus coeruleus contrast and diffusivity metrics differentially relate to age and memory performance
Scientific ReportsNeurocognitive aging researchers are increasingly focused on the locus coeruleus, a neuromodulatory brainstem structure that degrades with age. With this rapid growth, the field will benefit from consensus regarding which magnetic resonance imaging (MRI)
Ilana J. Bennett +5 more
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Biology, 2022 Alzheimer’s disease (AD), which is characterized by extracellular accumulation of amyloid-beta peptide and intracellular aggregation of hyperphosphorylated tau, is the most common form of dementia.
Dilek Mercan, Michael Thomas Heneka
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Selective WGA uptake in the hippocampus from the locus coeruleus of DBH-WGA transgenic mice
Frontiers in Behavioral Neuroscience, 2012 We generated transgenic mice in which a transsynaptic tracer, wheat germ agglutinin (WGA), was specifically expressed in the locus coeruleus neurons under the control of the dopamine-β-hydroxylase gene promoter. WGA protein was produced in more than 95%
Susan G eWalling +4 more
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