Results 1 to 10 of about 396,285 (245)
Locus Coeruleus Optogenetic Modulation: Lessons Learned from Temporal Patterns
Brain Sciences, 2021 After reviewing seminal studies using optogenetics to interrogate the functional role of the locus coeruleus in behavior, we conclude that differences in firing rates and firing patterns of locus coeruleus neurons contribute to locus coeruleus nucleus ...
Carolyn W. Harley, Qi Yuan
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The role of the locus coeruleus in the generation of pathological anxiety
Brain and Neuroscience Advances, 2020 This review aims to synthesise a large pre-clinical and clinical literature related to a hypothesised role of the locus coeruleus norepinephrine system in responses to acute and chronic threat, as well as the emergence of pathological anxiety.
Laurel S. Morris +3 more
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Locus coeruleus α-synuclein overexpression induces prodromal Parkinsonian features in mice [PDF]
npj Parkinson's DiseaseThe locus coeruleus is among the earliest brain regions affected by α-synuclein pathology in prodromal Parkinson’s disease, contributing to non-motor symptoms, yet its early pathogenic role remains unclear.
Jone Razquin +11 more
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Human narcolepsy is linked to degeneration of both locus coeruleus and hypocretin neurons [PDF]
Nature CommunicationsEarlier studies led to the conclusion that human narcolepsy with cataplexy was correlated with the loss of hypocretin (Hcrt = orexin) neurons in the hypothalamus.
Thomas C. Thannickal +3 more
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PLoS ONE, 2023 Patients with Parkinson’s disease undergo a loss of melanized neurons in substantia nigra pars compacta and locus coeruleus. Very few studies have assessed substantia nigra pars compacta and locus coeruleus pathology in Parkinson’s disease simultaneously
Kristy S. Hwang +4 more
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Locus coeruleus-norepinephrine: basic functions and insights into Parkinson’s disease
Neural Regeneration Research, 2020 The locus coeruleus is a pontine nucleus that produces much of the brain’s norepinephrine. Despite its small size, the locus coeruleus is critical for a myriad of functions and is involved in many neurodegenerative and neuropsychiatric disorders. In this
Bilal Abdul Bari +2 more
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Frontiers in Behavioral Neuroscience, 2022 Adolescence is a critical period of development with increased sensitivity toward psychological stressors. Many psychiatric conditions emerge during adolescence and animal studies have shown that that acute stress has long-term effects on hypothalamic ...
Olga Borodovitsyna +9 more
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Pupil tracks statistical regularities: behavioral and neural implications [PDF]
Journal of Integrative Neuroscience, 2020 Pupillary light reflex adjusts the amount of light reaching the retina. Recent work suggests that the brainstem pupillary light reflex pathway is controlled by the environment's internal models derived from higher-order temporal statistics.
Shamini Warda, Shubham Pandey
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Noradrenergic signaling mediates cortical early tagging and storage of remote memory
Nature Communications, 2022 The locus coeruleus norepinephrine system plays a role in various cognitive functions. Here the authors show that in mice, locus coeruleus to medial prefrontal cortex norepinephrine release and β1-AR signaling during contextual fear conditioning are ...
Xiaocen Fan +6 more
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PLoS Computational Biology, 2022 Apathy is a debilitating feature of many neuropsychiatric diseases, that is typically described as a reduction of goal-directed behaviour. Despite its prevalence and prognostic importance, the mechanisms underlying apathy remain controversial ...
Frank H Hezemans +14 more
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