Results 1 to 10 of about 411,191 (267)

The role of the locus coeruleus in the generation of pathological anxiety

Brain and Neuroscience Advances, 2020
This review aims to synthesise a large pre-clinical and clinical literature related to a hypothesised role of the locus coeruleus norepinephrine system in responses to acute and chronic threat, as well as the emergence of pathological anxiety.
James Murrough, Jordan G Mccall, Laurel S Morris   +2 more
exaly   +3 more sources

Locus coeruleus imaging as a biomarker for noradrenergic dysfunction in neurodegenerative diseases [PDF]

Brain, 2019
The locus coeruleus is the site of the earliest pathological changes in many neurodegenerative diseases. Betts et al. describe how in vivo locus coeruleus imaging can be used as a biomarker for noradrenergic dysfunction in neurodegenerative diseases, and
Nikolaus Weiskopf, Nikos Priovoulos, James Rowe   +2 more
exaly   +10 more sources

Acupuncture-induced changes in locus coeruleus connectivity and memory improvement in patients with amnestic cognitive impairment [PDF]

IBRO Neuroscience Reports
Background: An increasing number of neuroimaging studies have consistently indicated that the locus coeruleus is associated with cognitive impairment in the early stages of Alzheimer's disease, and the locus coeruleus plays a critical role in cognition ...
Liyu Hu, Xinbei Li, Juan Ou, Ting Liu, Xingxian Huang, Xingchen Liu, Yingqi Lu, Nan Yang, Jinhuan Zhang   +8 more
doaj   +2 more sources

Locus coeruleus-norepinephrine: basic functions and insights into Parkinson’s disease

Neural Regeneration Research, 2020
The locus coeruleus is a pontine nucleus that produces much of the brain’s norepinephrine. Despite its small size, the locus coeruleus is critical for a myriad of functions and is involved in many neurodegenerative and neuropsychiatric disorders. In this
Bilal Abdul Bari, Varun Chokshi, Katharina Schmidt   +2 more
doaj   +2 more sources

Human narcolepsy is linked to degeneration of both locus coeruleus and hypocretin neurons [PDF]

Nature Communications
Earlier studies led to the conclusion that human narcolepsy with cataplexy was correlated with the loss of hypocretin (Hcrt = orexin) neurons in the hypothalamus.
Thomas C. Thannickal, Ming-Fung Wu, Marcia E. Cornford, Jerome M. Siegel   +3 more
doaj   +2 more sources

Rapid Reconfiguration of the Functional Connectome after Chemogenetic Locus Coeruleus Activation

Neuron, 2019
The locus coeruleus (LC) supplies norepinephrine (NE) to the entire forebrain, regulates many fundamental brain functions, and is implicated in several neuropsychiatric diseases.
Oliver Sturman, Valerio Zerbi, Yannick Vermeiren   +2 more
exaly   +2 more sources

Noradrenergic-dependent functions are associated with age-related locus coeruleus signal intensity differences

Nature Communications, 2020
Alterations of locus coeruleus signal intensity have been associated with functional changes in health and disease. Here, the authors tested a pre-registered hypothesis on a large number of subjects as part of the Cam-CAN consortium.
Kathy Y. Liu, Rogier A. Kievit, Kamen A. Tsvetanov, Matthew J. Betts, Emrah Düzel, James B. Rowe, Cam-CAN, Robert Howard, Dorothea Hämmerer   +8 more
doaj   +2 more sources

In vivo detection of substantia nigra and locus coeruleus volume loss in Parkinson’s disease using neuromelanin-sensitive MRI: Replication in two cohorts

PLoS ONE, 2023
Patients with Parkinson’s disease undergo a loss of melanized neurons in substantia nigra pars compacta and locus coeruleus. Very few studies have assessed substantia nigra pars compacta and locus coeruleus pathology in Parkinson’s disease simultaneously
Kristy S. Hwang, Jason Langley, Richa Tripathi, Xiaoping P. Hu, Daniel E. Huddleston   +4 more
doaj   +3 more sources

The locus coeruleus broadcasts prediction errors across the cortex to promote sensorimotor plasticity

bioRxiv, 2023
Prediction errors are differences between expected and actual sensory input and are thought to be key computational signals that drive learning related plasticity.
Rebecca Jordan, Georg B. Keller
semanticscholar   +1 more source

The locus coeruleus as a global model failure system.

Trends in Neurosciences, 2023
Predictive processing models posit that brains constantly attempt to predict their sensory inputs. Prediction errors signal when these predictions are incorrect and are thought to be instructive signals that drive corrective plasticity.
Rebecca Jordan
semanticscholar   +1 more source