Results 21 to 30 of about 31,294 (247)

Pain and depression comorbidity causes asymmetric plasticity in the locus coeruleus neurons [PDF]

, 2022
There is strong comorbidity between chronic pain and depression, although the neural circuits and mechanisms underlying this association remain unclear.
Camarena Delgado, María del Carmen, López Martín, Carolina, García Partida, José Antonio, Mariscal Ramírez, Patricia, Suárez-Pereira, Irene, Micó Segura, Juan Antonio, Berrocoso Domínguez, Esther María, Bravo García, Lidia, Wei, Hong, Llorca Torralba, Meritxell, Pertovaara, Antti   +10 more
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Locus Coeruleus magnetic resonance imaging in cognitively intact elderly subjects [PDF]

, 2021
\ua9 2021, The Author(s).The locus coeruleus is the main noradrenergic nucleus of the brain and is often affected in neurodegenerative diseases. Recently, magnetic resonance imaging with specific T1-weighted sequences for neuromelanin has been used to ...
Fornai F., De Marchi D, Martini N, Giorgi FS, Bonuccelli U, Ghicopulos I, Bastiani L., Coi A., Galgani A, Bonuccelli U., Lombardo F., Fornai F, Coi A, Martini N., Hlavata H., Hlavata H, Pavese N., Della Latta D., Lombardo F, Baldacci F., Giorgi F. S., Bastiani L, Scalese M., Ghicopulos I., Keilberg P., Baldacci F, Della Latta D, Galgani A., Scalese M, Keilberg P, De Marchi D., Pavese N   +31 more
core   +1 more source

Locus coeruleus-norepinephrine: basic functions and insights into Parkinson’s disease

Neural Regeneration Research, 2020
The locus coeruleus is a pontine nucleus that produces much of the brain’s norepinephrine. Despite its small size, the locus coeruleus is critical for a myriad of functions and is involved in many neurodegenerative and neuropsychiatric disorders. In this
Bilal Abdul Bari, Varun Chokshi, Katharina Schmidt   +2 more
doaj   +1 more source

The locus coeruleus and central chemosensitivity [PDF]

Respiratory Physiology & Neurobiology, 2010
The locus coeruleus (LC) lies in the dorsal pons and supplies noradrenergic (NA) input to many regions of the brain, including respiratory control areas. The LC may provide tonic input for basal respiratory drive and is involved in central chemosensitivity since focal acidosis of the region stimulates ventilation and ablation reduces CO(2)-induced ...
Gargaglioni, Luciane H., Hartzler, Lynn K., Putnam, Robert W.   +2 more
openaire   +4 more sources

Age- and Sex-Dependent Changes in Locus Coeruleus Physiology and Anxiety-Like Behavior Following Acute Stressor Exposure

Frontiers in Behavioral Neuroscience, 2022
Adolescence is a critical period of development with increased sensitivity toward psychological stressors. Many psychiatric conditions emerge during adolescence and animal studies have shown that that acute stress has long-term effects on hypothalamic ...
Olga Borodovitsyna, Olga Borodovitsyna, John A. Tkaczynski, John A. Tkaczynski, Claire M. Corbett, Claire M. Corbett, Jessica A. Loweth, Jessica A. Loweth, Daniel J. Chandler, Daniel J. Chandler   +9 more
doaj   +1 more source

Pupil tracks statistical regularities: behavioral and neural implications [PDF]

Journal of Integrative Neuroscience, 2020
Pupillary light reflex adjusts the amount of light reaching the retina. Recent work suggests that the brainstem pupillary light reflex pathway is controlled by the environment's internal models derived from higher-order temporal statistics.
Shamini Warda, Shubham Pandey
doaj   +1 more source

Vulnerability of the locus coeruleus-entorhinal cortex white matter tract in autosomal dominant Alzheimer's disease. [PDF]

Alzheimers Dement
Abstract INTRODUCTION Locus coeruleus (LC) structural integrity declines early in sporadic and autosomal dominant Alzheimer's disease (AD). We examined LC–entorhinal cortex (LC‐EC) tract integrity and its association with amyloid and tau pathology and memory in autosomal dominant AD (ADAD).
Koops EA, Giudicessi A, Baena A, Martinez L, Bonillas-Felix N, Medrano R, Dutta J, Gonzalez I, Alvarez S, Aguillon D, Quiroz YT, Jacobs HIL.   +11 more
europepmc   +2 more sources

Noradrenergic signaling mediates cortical early tagging and storage of remote memory

Nature Communications, 2022
The locus coeruleus norepinephrine system plays a role in various cognitive functions. Here the authors show that in mice, locus coeruleus to medial prefrontal cortex norepinephrine release and β1-AR signaling during contextual fear conditioning are ...
Xiaocen Fan, Jiachen Song, Chaonan Ma, Yanbo Lv, Feifei Wang, Lan Ma, Xing Liu   +6 more
doaj   +1 more source

Noradrenergic deficits contribute to apathy in Parkinson's disease through the precision of expected outcomes.

PLoS Computational Biology, 2022
Apathy is a debilitating feature of many neuropsychiatric diseases, that is typically described as a reduction of goal-directed behaviour. Despite its prevalence and prognostic importance, the mechanisms underlying apathy remain controversial ...
Frank H Hezemans, Noham Wolpe, Claire O'Callaghan, Rong Ye, Catarina Rua, P Simon Jones, Alexander G Murley, Negin Holland, Ralf Regenthal, Kamen A Tsvetanov, Roger A Barker, Caroline H Williams-Gray, Trevor W Robbins, Luca Passamonti, James B Rowe   +14 more
doaj   +1 more source

Localisation of NG2 immunoreactive neuroglia cells in the rat locus coeruleus and their plasticity in response to stress [PDF]

, 2014
The locus coeruleus (LC) nucleus modulates adaptive behavioural responses to stress and dysregulation of LC neuronal activity is implicated in stress-induced mental illnesses.
Metzger, Friedrich, Friedrich Metzger, Metzger, F, Seifi, Mohsen, Mohsen eSeifi, Johannes J. van der Want, Corteen, Nicole L, Jerome D Swinny, van der Want, Johannes J, Corteen, Nicole L., Seifi, M, Swinny, Jerome D, Corteen, NL, Johannes Jacobus Van Der Want, Nicole L. Corteen, Swinny, Jerome D., Swinny, JD, van der Want, Johannes J., van der Want, Johannes, Nicole Louise Corteen, Mohsen Seifi, Jerome D. Swinny, Friedrich eMetzger   +22 more
core   +1 more source