Results 21 to 30 of about 396,285 (245)

Tuning arousal with optogenetic modulation of locus coeruleus neurons. [PDF]

, 2010
Neural activity in the noradrenergic locus coeruleus correlates with periods of wakefulness and arousal. However, it is unclear whether tonic or phasic activity in these neurons is necessary or sufficient to induce transitions between behavioral states ...
de Lecea, Luis, Karl Deisseroth, Carter, Matthew E, Deisseroth, Karl, Antoine Adamantidis, Seiji Nishino, Nguyen, Hieu, Luis de Lecea, Ofer Yizhar, Hieu Nguyen, Matthew E Carter, Sachiko Chikahisa, Adamantidis, Antoine Roger, Yizhar, Ofer, Nishino, Seiji, Chikahisa, Sachiko   +15 more
core   +1 more source

The Longevity of Hippocampus-Dependent Memory Is Orchestrated by the Locus Coeruleus-Noradrenergic System

Neural Plasticity, 2017
The locus coeruleus is connected to the dorsal hippocampus via strong fiber projections. It becomes activated after arousal and novelty, whereupon noradrenaline is released in the hippocampus.
Niels Hansen
doaj   +1 more source

Locus coeruleus-noradrenergic modulation of trigeminal pain: Implications for trigeminal neuralgia and psychiatric comorbidities

Neurobiology of Pain, 2023
Trigeminal neuralgia is the most common neuropathic pain involving the craniofacial region. Due to the complex pathophysiology, it is therapeutically difficult to manage.
Basak Donertas-Ayaz, Robert M. Caudle
doaj   +1 more source

Less locus coeruleus degeneration and its enhanced influence on neural circuit in Parkinson's tremor

Neurobiology of Disease
Objectives: The involvement of the locus coeruleus in Parkinson's tremor remains unclear. We aimed to decode the role of locus coeruleus in Parkinson's tremor. Methods: We used MRI to examine 120 Parkinson's disease, including 48 tremor-dominant (TD) and
Junyan Sun, Lili Chen, Liang Li, Tao Wu, Tao Feng   +4 more
doaj   +1 more source

Combined Optogenetic Approaches Reveal Quantitative Dynamics of Endogenous Noradrenergic Transmission in the Brain

iScience, 2020
Summary: Little is known about the real-time cellular dynamics triggered by endogenous catecholamine release despite their importance in brain functions. To address this issue, we expressed channelrhodopsin in locus coeruleus neurons and protein kinase-A
Shinobu Nomura, Ludovic Tricoire, Ivan Cohen, Bernd Kuhn, Bertrand Lambolez, Régine Hepp   +5 more
doaj   +1 more source

Acupuncture-induced changes in locus coeruleus connectivity and memory improvement in patients with amnestic cognitive impairment

IBRO Neuroscience Reports
Background: An increasing number of neuroimaging studies have consistently indicated that the locus coeruleus is associated with cognitive impairment in the early stages of Alzheimer's disease, and the locus coeruleus plays a critical role in cognition ...
Liyu Hu, Xinbei Li, Juan Ou, Ting Liu, Xingxian Huang, Xingchen Liu, Yingqi Lu, Nan Yang, Jinhuan Zhang   +8 more
doaj   +1 more source

A53T-α-synuclein overexpression in murine locus coeruleus induces Parkinson’s disease-like pathology in neurons and glia

Acta Neuropathologica Communications, 2018
Degeneration of noradrenergic locus coeruleus neurons occurs during the prodromal phase of Parkinson’s disease and contributes to a variety of non-motor symptoms, e.g. depression, anxiety and REM sleep behavior disorder.
Martin Timo Henrich, Fanni Fruzsina Geibl, Bolam Lee, Wei-Hua Chiu, James Benjamin Koprich, Jonathan Michael Brotchie, Lars Timmermann, Niels Decher, Lina Anita Matschke, Wolfgang Hermann Oertel   +9 more
doaj   +1 more source

Locus coeruleus pathology in progressive supranuclear palsy, and its relation to disease severity

Acta Neuropathologica Communications, 2020
The locus coeruleus is the major source of noradrenaline to the brain and contributes to a wide range of physiological and cognitive functions including arousal, attention, autonomic control, and adaptive behaviour.
Sanne Simone Kaalund, Luca Passamonti, Kieren S. J. Allinson, Alexander G. Murley, Trevor W. Robbins, Maria Grazia Spillantini, James B. Rowe   +6 more
doaj   +1 more source

Effects of Noninvasive Cervical Vagal Nerve Stimulation on Cognitive Performance But Not Brain Activation in Healthy Adults

Neuromodulation: Technology at the Neural Interface, EarlyView., 2020
Abstract Objectives While preliminary evidence suggests that noninvasive vagal nerve stimulation (nVNS) may enhance cognition, to our knowledge, no study has directly assessed the effects of nVNS on brain function and cognitive performance in healthy individuals.
Ruth Klaming, Alan N. Simmons, Andrea D. Spadoni, Imanuel Lerman   +3 more
wiley   +1 more source

The effects of adenosine on the electrophysiological properties of locus coeruleus neurons.

, 1995
The effects of adenosine on the electrophysiological properties of locus coeruleus ...
Wilbur James. Pan (7970054)
core   +3 more sources