Tuning arousal with optogenetic modulation of locus coeruleus neurons. [PDF]
, 2010 Neural activity in the noradrenergic locus coeruleus correlates with periods of wakefulness and arousal. However, it is unclear whether tonic or phasic activity in these neurons is necessary or sufficient to induce transitions between behavioral states ...
de Lecea, Luis +15 more
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Frontiers in Behavioral Neuroscience, 2022 Adolescence is a critical period of development with increased sensitivity toward psychological stressors. Many psychiatric conditions emerge during adolescence and animal studies have shown that that acute stress has long-term effects on hypothalamic ...
Olga Borodovitsyna +9 more
doaj +1 more source
Pupil tracks statistical regularities: behavioral and neural implications [PDF]
Journal of Integrative Neuroscience, 2020 Pupillary light reflex adjusts the amount of light reaching the retina. Recent work suggests that the brainstem pupillary light reflex pathway is controlled by the environment's internal models derived from higher-order temporal statistics.
Shamini Warda, Shubham Pandey
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Noradrenergic signaling mediates cortical early tagging and storage of remote memory
Nature Communications, 2022 The locus coeruleus norepinephrine system plays a role in various cognitive functions. Here the authors show that in mice, locus coeruleus to medial prefrontal cortex norepinephrine release and β1-AR signaling during contextual fear conditioning are ...
Xiaocen Fan +6 more
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Pain and depression comorbidity causes asymmetric plasticity in the locus coeruleus neurons [PDF]
, 2022 There is strong comorbidity between chronic pain and depression, although the neural circuits and mechanisms underlying this association remain unclear.
Camarena Delgado, María del Carmen +10 more
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PLoS Computational Biology, 2022 Apathy is a debilitating feature of many neuropsychiatric diseases, that is typically described as a reduction of goal-directed behaviour. Despite its prevalence and prognostic importance, the mechanisms underlying apathy remain controversial ...
Frank H Hezemans +14 more
doaj +1 more source
A possible role of the locus coeruleus in complex regional pain syndrome [PDF]
, 2012 Heightened sensitivity to painful stimulation commonly spreads from the affected limb to the ipsilateral forehead in patients with complex regional pain syndrome (CRPS).
Peter D Drummond +2 more
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Localisation of NG2 immunoreactive neuroglia cells in the rat locus coeruleus and their plasticity in response to stress [PDF]
, 2014 The locus coeruleus (LC) nucleus modulates adaptive behavioural responses to stress and dysregulation of LC neuronal activity is implicated in stress-induced mental illnesses.
Metzger, Friedrich +22 more
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A Reciprocal Relationship Between Bottom-up Trace Strength and the Attentional Blink Bottleneck: Relating the LC-NE and ST2 Models [PDF]
, 2008 There is considerable current interest in neural modelling of the attentional blink phenomenon. Two prominent models of this task are the Simultaneous Type Serial Token (ST2) model and the Locus Coeruleus Norepinephrine (LC-NE) model. The former of these
Craston, Patrick +3 more
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Modulation of physiological reflexes by pain: role of the locus coeruleus
Frontiers in Integrative Neuroscience, 2012 The locus coeruleus is activated by noxious stimuli, and this activation leads to inhibition of perceived pain. As two physiological reflexes, the acoustic startle reflex and the pupillary light reflex, are sensitive to noxious stimuli, this sensitivity,
Elemer eSzabadi
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