Results 31 to 40 of about 31,294 (247)

A Reciprocal Relationship Between Bottom-up Trace Strength and the Attentional Blink Bottleneck: Relating the LC-NE and ST2 Models [PDF]

open access: yes, 2008
There is considerable current interest in neural modelling of the attentional blink phenomenon. Two prominent models of this task are the Simultaneous Type Serial Token (ST2) model and the Locus Coeruleus Norepinephrine (LC-NE) model. The former of these
Craston, Patrick   +3 more
core   +1 more source

Fluid intelligence and the locus coeruleus–norepinephrine system

open access: yes, 2021
The last decade has seen significant progress identifying genetic and brain differences related to intelligence. However, there remain considerable gaps in our understanding of how cognitive mechanisms that underpin intelligence map onto various brain ...
Tsukahara, Jason S.   +3 more
core   +2 more sources

Locus Coeruleus in Non-Mammalian Vertebrates

open access: yesBrain Sciences, 2022
The locus coeruleus (LC) is a vertebrate-specific nucleus and the primary source of norepinephrine (NE) in the brain. This nucleus has conserved properties across species: highly homogeneous cell types, a small number of cells but extensive axonal ...
Sijia Wang, Zhirong Wang, Yu Mu
doaj   +1 more source

Locus coeruleus-noradrenergic modulation of trigeminal pain: Implications for trigeminal neuralgia and psychiatric comorbidities

open access: yesNeurobiology of Pain, 2023
Trigeminal neuralgia is the most common neuropathic pain involving the craniofacial region. Due to the complex pathophysiology, it is therapeutically difficult to manage.
Basak Donertas-Ayaz, Robert M. Caudle
doaj   +1 more source

Regional locus coeruleus degeneration is uncoupled from noradrenergic terminal loss in Parkinson’s disease

open access: yes, 2022
Previous studies have reported substantial involvement of the noradrenergic system in Parkinson’s disease. Neuromelanin-sensitive MRI sequences and PET tracers have become available to visualize the cell bodies in the locus coeruleus and the density of ...
Kinnerup, Martin B   +16 more
core   +1 more source

Combined Optogenetic Approaches Reveal Quantitative Dynamics of Endogenous Noradrenergic Transmission in the Brain

open access: yesiScience, 2020
Summary: Little is known about the real-time cellular dynamics triggered by endogenous catecholamine release despite their importance in brain functions. To address this issue, we expressed channelrhodopsin in locus coeruleus neurons and protein kinase-A
Shinobu Nomura   +5 more
doaj   +1 more source

Less locus coeruleus degeneration and its enhanced influence on neural circuit in Parkinson's tremor

open access: yesNeurobiology of Disease
Objectives: The involvement of the locus coeruleus in Parkinson's tremor remains unclear. We aimed to decode the role of locus coeruleus in Parkinson's tremor. Methods: We used MRI to examine 120 Parkinson's disease, including 48 tremor-dominant (TD) and
Junyan Sun   +4 more
doaj   +1 more source

A53T-α-synuclein overexpression in murine locus coeruleus induces Parkinson’s disease-like pathology in neurons and glia

open access: yesActa Neuropathologica Communications, 2018
Degeneration of noradrenergic locus coeruleus neurons occurs during the prodromal phase of Parkinson’s disease and contributes to a variety of non-motor symptoms, e.g. depression, anxiety and REM sleep behavior disorder.
Martin Timo Henrich   +9 more
doaj   +1 more source

Locus coeruleus pathology in progressive supranuclear palsy, and its relation to disease severity

open access: yesActa Neuropathologica Communications, 2020
The locus coeruleus is the major source of noradrenaline to the brain and contributes to a wide range of physiological and cognitive functions including arousal, attention, autonomic control, and adaptive behaviour.
Sanne Simone Kaalund   +6 more
doaj   +1 more source

A possible role of the locus coeruleus in complex regional pain syndrome

open access: yes, 2012
Heightened sensitivity to painful stimulation commonly spreads from the affected limb to the ipsilateral forehead in patients with complex regional pain syndrome (CRPS).
Peter D Drummond   +2 more
core   +1 more source

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