Results 31 to 40 of about 411,191 (267)
Frontiers in Behavioral Neuroscience, 2022 Adolescence is a critical period of development with increased sensitivity toward psychological stressors. Many psychiatric conditions emerge during adolescence and animal studies have shown that that acute stress has long-term effects on hypothalamic ...
Olga Borodovitsyna +9 more
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Pupil tracks statistical regularities: behavioral and neural implications [PDF]
Journal of Integrative Neuroscience, 2020 Pupillary light reflex adjusts the amount of light reaching the retina. Recent work suggests that the brainstem pupillary light reflex pathway is controlled by the environment's internal models derived from higher-order temporal statistics.
Shamini Warda, Shubham Pandey
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Frontiers in Neural Circuits, 2021 The locus coeruleus (LC), a small brainstem nucleus, is the primary source of the neuromodulator norepinephrine (NE) in the brain. The LC receives input from widespread brain regions, and projects throughout the forebrain, brainstem, cerebellum, and ...
Vincent Breton-Provencher +2 more
semanticscholar +1 more source
Locus Coeruleus Integrity from 7 T MRI Relates to Apathy and Cognition in Parkinsonian Disorders
Movement Disorders, 2022 Neurodegeneration in the locus coeruleus (LC) contributes to neuropsychiatric symptoms in both Parkinson's disease (PD) and progressive supranuclear palsy (PSP).
R. Ye +11 more
semanticscholar +1 more source
Locus coeruleus in the pathogenesis of Alzheimer's disease: A systematic review
Alzheimer's & Dementia, 2022 The locus coeruleus (LC) is a nucleus in the brain stem producing noradrenaline. While cognitive decline in Alzheimer's disease (AD) has primarily been related to cholinergic depletion, evidence indicates extensive LC degeneration as its earliest ...
Yuqing Chen, Teng Chen, R. Hou
semanticscholar +1 more source
Noradrenergic signaling mediates cortical early tagging and storage of remote memory
Nature Communications, 2022 The locus coeruleus norepinephrine system plays a role in various cognitive functions. Here the authors show that in mice, locus coeruleus to medial prefrontal cortex norepinephrine release and β1-AR signaling during contextual fear conditioning are ...
Xiaocen Fan +6 more
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Locus coeruleus: a new look at the blue spot
Nature Reviews Neuroscience, 2020 The locus coeruleus (LC), or ‘blue spot’, is a small nucleus located deep in the brainstem that provides the far-reaching noradrenergic neurotransmitter system of the brain.
G. Poe +13 more
semanticscholar +1 more source
Real-world stress resilience is associated with the responsivity of the locus coeruleus
Nature Communications, 2021 Individuals may show different responses to stressful events. Here, we investigate the neurobiological basis of stress resilience, by showing that neural responsitivity of the noradrenergic locus coeruleus (LC-NE) and associated pupil responses are ...
M. Grueschow +9 more
semanticscholar +1 more source
PLoS Computational Biology, 2022 Apathy is a debilitating feature of many neuropsychiatric diseases, that is typically described as a reduction of goal-directed behaviour. Despite its prevalence and prognostic importance, the mechanisms underlying apathy remain controversial ...
Frank H Hezemans +14 more
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The Locus Coeruleus in Aging and Alzheimer’s Disease: A Postmortem and Brain Imaging Review
Journal of Alzheimer's Disease, 2021 The locus coeruleus (LC), a tiny nucleus in the brainstem and the principal site of noradrenaline synthesis, has a major role in regulating autonomic function, arousal, attention, and neuroinflammation.
Rebecca C. Beardmore +4 more
semanticscholar +1 more source