Results 51 to 60 of about 31,294 (247)

The Contribution of the Locus Coeruleus–Noradrenaline System Degeneration during the Progression of Alzheimer’s Disease

Biology, 2022
Alzheimer’s disease (AD), which is characterized by extracellular accumulation of amyloid-beta peptide and intracellular aggregation of hyperphosphorylated tau, is the most common form of dementia.
Dilek Mercan, Michael Thomas Heneka
doaj   +1 more source

Astrocytic Phenotypic Switching in Posterior Piriform Cortex Orchestrates Bone Cancer Pain–Depression Comorbidity via Purinergic–Noradrenergic Signaling

Advanced Science, EarlyView.
Bone cancer pain and depression share a common origin: astrocytic A2‐to‐A1 transition in the posterior piriform cortex. This phenotypic shift disrupts the ATP–adenosine–A2AR–norepinephrine axis, simultaneously driving nociceptive and affective dysfunction.
Jiang‐Ping Liu, Jun‐Han Zhang, Zhi‐Xuan Tan, Wei‐Bing Yan, Ya‐Ru Yuan, Yao Liu, Bing‐Di Wei, Meng‐Qi Ding, Zhuo‐Min Fu, Ying Liu, An‐Qi Wang, Lin Ma, Yong‐Hong Li, Er‐Qing Chai, Chao‐Jun Wei   +14 more
wiley   +1 more source

Scalp electroacupuncture targeting trigeminal nerve activation alleviates post‐traumatic stress disorder–induced depression and neuroinflammation in mice

Animal Models and Experimental Medicine, EarlyView.
Scalp electroacupuncture (SA) through activation of the trigeminal pathway exerts anti‐inflammatory, antidepressant, and anxiolytic effects in an animal model of post‐traumatic stress disorder induced by single prolonged stress. This suggests that SA is involved in neuroinflammation and changes in brain‐derived neurotrophic factor protein through the ...
Bombi Lee, Yoongeun Kim, Hyungjun Kim, Dae‐Hyun Hahm   +3 more
wiley   +1 more source

Correlations with locus coeruleus (LC).

, 2019
Correlations with locus coeruleus (LC).
Russell Schachar (760461), Jonathan Lipszyc (6383813), Mehereen Bhaijiwala (6383810), Andre Chevrier (5664088), Simon Graham (760460), Douglas Cheyne (760459)   +5 more
core   +1 more source

Locus coeruleus and dopaminergic consolidation of everyday memory [PDF]

, 2016
The retention of episodic-like memory is enhanced, in humans and animals, when something novel happens shortly before or after encoding. Using an everyday memory task in mice, we sought the neurons mediating this dopamine-dependent novelty effect ...
Yamasaki, Miwako, Karl Deisseroth, Duszkiewicz, A.J., Greene, R.W., Richard G. M. Morris, Morris, Richard G., Spooner, P.A., Duszkiewicz, Adrian J., Deisseroth, K., Morris, R.G., Alex Sonneborn, Robert W. Greene, Greene, Robert W., Watanabe, M., Miwako Yamasaki, Spooner, Patrick A., Deisseroth, Karl, Takeuchi, Tomonori, Tomonori Takeuchi, Caroline C. Smith, Smith, C.C., Fernandez, G.S.E., Watanabe, Masahiko, Masahiko Watanabe, Smith, Caroline C., Takeuchi, T., Yamasaki, M., Morris, Richard G. M., Patrick A. Spooner, Guillén Fernández, Sonneborn, A., Adrian J. Duszkiewicz, Fernández, Guillén, Sonneborn, Alex   +33 more
core   +1 more source

The Locus Coeruleus Noradrenaline System in Delirium

Frontiers in Aging Neuroscience, 2021
Delirium is a brain state involving severe brain dysfunction affecting cognitive and attentional capacities. Our opinion statement review aims to elucidate the relationship between abnormal arousal and locus coeruleus (LC) activity in cognitive ...
Niels Hansen, Alina Isabel Rediske
doaj   +1 more source

Locus coeruleus and labile memory

Pharmacology Biochemistry and Behavior, 1978
Abstract Memory lability is defined as the period of time recently-formed memory remains susceptible to experimental modification. Electrolytic lesions delivered through chronic indwelling electrodes to the locus coeruleus (LC) complex of mice, made shortly after learning, resulted in an extension of memory lability.
Department of Neuroscience, College of Medicine, University of Florida Gainesville, FL 32610, USA ( host institution ), Zornetzer, Steven F., Abraham, Wickliffe C., Appleton, Robert   +3 more
openaire   +3 more sources

Post‐LECA Origin and Diversification of an Axonemal Outer Arm Dynein Motor

Cytoskeleton, EarlyView.
ABSTRACT Dyneins were present in the last eukaryotic common ancestor (LECA) and play key roles in eukaryotic biology. Axonemal dyneins form the inner and outer arms that power ciliary beating, and it has long been recognized that outer arms in some organisms contain two different heavy chain motors, whereas those from other species contain a third unit
Stephen M. King
wiley   +1 more source

Selective WGA uptake in the hippocampus from the locus coeruleus of DBH-WGA transgenic mice

Frontiers in Behavioral Neuroscience, 2012
We generated transgenic mice in which a transsynaptic tracer, wheat germ agglutinin (WGA), was specifically expressed in the locus coeruleus neurons under the control of the dopamine-β-hydroxylase gene promoter. WGA protein was produced in more than 95%
Susan G eWalling, Robert A.M. Brown, Nobuhiko eMIYASAKA, Yoshihiro eYoshihara, Carolyn W Harley   +4 more
doaj   +1 more source

Hypocretin/orexin influences chronic sleep disruption injury in the hippocampus

Frontiers in Aging Neuroscience, 2022
Chronic sleep disruption is a risk factor for Alzheimer’s disease (AD), yet mechanisms by which sleep disturbances might promote or exacerbate AD are not understood.
Henry Nick, Polina Fenik, Yan Zhu, Sigrid Veasey   +3 more
doaj   +1 more source