Results 51 to 60 of about 396,285 (245)
Apathy in Lewy Body Disorders: A Position Paper
Movement Disorders, EarlyView.Abstract Apathy is one of the most prevalent and disabling non‐motor symptoms in Parkinson's disease (PD) and dementia with Lewy bodies (DLB), collectively referred to as Lewy body disorders (LBDs). It is associated with reduced quality of life, accelerated cognitive decline, increased caregiver burden, and poorer functional outcomes, yet remains ...
Jaime Kulisevsky +12 more
wiley +1 more source
Hypocretin/orexin influences chronic sleep disruption injury in the hippocampus
Frontiers in Aging Neuroscience, 2022 Chronic sleep disruption is a risk factor for Alzheimer’s disease (AD), yet mechanisms by which sleep disturbances might promote or exacerbate AD are not understood.
Henry Nick +3 more
doaj +1 more source
Movement Disorders, EarlyView.Abstract The neuropathology of Parkinson's disease (PD) is characterized in part by the degeneration of catecholaminergic neurons, particularly dopaminergic neurons in the substantia nigra pars compacta (SNpc) and noradrenergic neurons in the locus coeruleus (LC), yet no validated in vivo biomarker quantifies this process.
Rayo Akande +5 more
wiley +1 more source
Pediatric Investigation, EarlyView.This review synthesizes epidemiological evidence linking atopic dermatitis to attention‐deficit/hyperactivity disorder in children, proposes an “inflammation‐itch‐neurobehavioral axis” integrating sleep disruption, neuroendocrine dysregulation, and emerging neuro‐immune circuits, and outlines multidisciplinary management strategies targeting both skin ...
Qingyang Zhao +11 more
wiley +1 more source
针刺研究, 1986 Our experiments showed that analgesic electroacupuncture (EA: 8c/s, 3V) had a pressor effect in conscious paralysed male rats under artificial respiration.
李慧麟, 周燕春, 顾蕴辉
doaj +2 more sources
Potential value of slow‐wave sleep in management of chronic insomnia disorder
Sleep Research, EarlyView.Abstract Chronic insomnia disorder (CID), acknowledged as the most common sleep disorder, has traditionally been diagnosed and managed with a focus on reducing sleep onset latency and extending total sleep duration. However, the critical importance of slow‐wave sleep (SWS), a key indicator of objective sleep quality, has been largely overlooked in ...
Liping Zhang +4 more
wiley +1 more source
Communications Biology, 2023 Chemogenetic and optogenetic profiling in a rat model of acute pain-related unpleasantness suggests that colorectal distention-induced place aversion is mediated by locus coeruleus noradrenergic signalling to astrocytes in anterior cingulate cortex.
Zafar Iqbal +7 more
doaj +1 more source
Neuropathology of a patient with Parkinson's disease and biallelic expansion in RFC1
Brain Pathology, EarlyView.This is the first report of neuropathology in biallelic RFC1 expansion‐associated Parkinson’s disease (PD). It shows a synucleinopathy of intraneuronal Lewy bodies consistent with the clinical PD diagnosis while neuropathological CANVAS (Cerebellar Ataxia with Neuropathy and bilateral Vestibular Areflexia) features were absent.
Jussi Sipilä +3 more
wiley +1 more source
Respiratory entrainment of the locus coeruleus modulates arousal level
, 2023 This research is related to computational modeling of LC-NE system and cardio-respiratory system. The model demonstrates that respiratory entrainment of the Locus coeruleus (LC) modulates arousal levels in order for one to avoid physical risks from ...
Masami Iwamoto
core +1 more source
Chronic traumatic encephalopathy in a neuropathologically confirmed Creutzfeldt–Jakob disease cohort
Brain Pathology, EarlyView.Systematic neuropathological screening of 212 patients with Creutzfeldt–Jakob disease (55% women) identified chronic traumatic encephalopathy in three cases (1.4%), all men with a history of contact sports. These findings represent the first neuropathologically confirmed chronic traumatic encephalopathy cases reported in Spain.
Lluc Bertran +13 more
wiley +1 more source