Results 71 to 80 of about 411,191 (267)
Advanced Science, EarlyView.Bone cancer pain and depression share a common origin: astrocytic A2‐to‐A1 transition in the posterior piriform cortex. This phenotypic shift disrupts the ATP–adenosine–A2AR–norepinephrine axis, simultaneously driving nociceptive and affective dysfunction.
Jiang‐Ping Liu +14 more
wiley +1 more source
Molecular Pain, 2017 N-acetylaspartylglutamate (NAAG) is the third most prevalent and widely distributed neurotransmitter in the mammalian nervous system. NAAG activates a group II metabotropic glutamate receptor (mGluR3) and is inactivated by an extracellular enzyme ...
Takahiro Nonaka +6 more
doaj +1 more source
Angewandte Chemie International Edition, EarlyView.Following a structure‐based design approach, photoswitchable derivatives of the FDA‐approved drug suvorexant were designed, docked, synthesized, and characterized pharmacologically at the orexin 1 and 2 receptors (OX1R and OX2R). Optimized “photorexant” showed up to an 11‐fold difference in IC50 between photoisomers, enabled dynamic and reversible ...
Marcus Angermann +10 more
wiley +1 more source
Locus coeruleus stimulation by corticotropin-releasing hormone suppresses in vitro cellular immune responses [PDF]
, 1994 Previous studies have demonstrated that stressors alter cellular immune system function, and increase the activity of locus coeruleus neurons. Furthermore, stressors increase the release of corticotropin-releasing hormone (CRH) and locus coeruleus ...
S Rassnick, BS Rabin, AF Sved
core +1 more source
Biology, 2022 Alzheimer’s disease (AD), which is characterized by extracellular accumulation of amyloid-beta peptide and intracellular aggregation of hyperphosphorylated tau, is the most common form of dementia.
Dilek Mercan, Michael Thomas Heneka
doaj +1 more source
Autism Research, EarlyView.ABSTRACT According to prevalent views, autistic individuals have a stronger tendency to allocate attention to details, as supported by reports of enhanced visual search performance. However, both the dynamics and the types of information involved in attentional guidance in autism are not fully understood.
Zainab Naaran, Amit Yashar
wiley +1 more source
An in vivo Probabilistic Atlas of the Human Locus Coeruleus at Ultra-high Field
bioRxiv, 2020 Early and profound pathological changes are evident in the locus coeruleus (LC) in dementia and Parkinson’s disease, with effects on arousal, attention, cognitive and motor control.
R. Ye +11 more
semanticscholar +1 more source
Locus coeruleus and labile memory
Pharmacology Biochemistry and Behavior, 1978 Abstract Memory lability is defined as the period of time recently-formed memory remains susceptible to experimental modification. Electrolytic lesions delivered through chronic indwelling electrodes to the locus coeruleus (LC) complex of mice, made shortly after learning, resulted in an extension of memory lability.
Department of Neuroscience, College of Medicine, University of Florida Gainesville, FL 32610, USA ( host institution ) +3 more
openaire +3 more sources
British Journal of Clinical Pharmacology, EarlyView.Chronic pain represents a complex debilitating condition that extends beyond the protective function of physiological pain, often persisting as an independent disease entity. Chronic primary and secondary pain syndromes reflect a multifaceted continuum involving nociceptive, neuropathic and nociplastic mechanisms.
Stefania Nobili +6 more
wiley +1 more source
Selective WGA uptake in the hippocampus from the locus coeruleus of DBH-WGA transgenic mice
Frontiers in Behavioral Neuroscience, 2012 We generated transgenic mice in which a transsynaptic tracer, wheat germ agglutinin (WGA), was specifically expressed in the locus coeruleus neurons under the control of the dopamine-β-hydroxylase gene promoter. WGA protein was produced in more than 95%
Susan G eWalling +4 more
doaj +1 more source