Effect of sensory deprivation and Locus Coeruleus (LC) electrical stimulation on the response properties of layer IV barrel cortex neurons in male rats [PDF]
Introduction: Barrel cortex of rodents is responsible for sensory information processing from muzzle whiskers. Locus coeruleus (LC) as the main source of norepinephrine (NE) in the cortex, is effective on the sensory information processing. Methods:
شمسی زاده, علی +4 more
core
British Journal of Pharmacology, EarlyView.Background and Purpose Degeneration of the pontine noradrenergic and midbrain dopaminergic systems contributes to cognitive‐behavioural disturbances during the prodromal stages of Alzheimer's disease (AD). We developed a genetically engineered, programmable probiotic Escherichia coli Nissle 1917 strain (EcNrhaL‐DOPA) capable of producing L‐3,4 ...
Mona Abdelhamid +9 more
wiley +1 more source
Regional locus coeruleus degeneration is uncoupled from noradrenergic terminal loss in Parkinson’s disease [PDF]
Previous studies have reported substantial involvement of the noradrenergic system in Parkinson’s disease. Neuromelanin-sensitive MRI sequences and PET tracers have become available to visualize the cell bodies in the locus coeruleus and the density of ...
Borghammer P +16 more
core +4 more sources
Molecular and Functional Sex Differences of Noradrenergic Neurons in the Mouse Locus Coeruleus
Cell Reports, 2018 Summary: Preclinical work has long focused on male animals, though biological sex clearly influences risk for certain diseases, including many psychiatric disorders.
Bernard Mulvey +8 more
doaj +1 more source
A distinct neuromelanin magnetic resonance imaging pattern in parkinsonian multiple system atrophy
BMC Neurology, 2020 Background Parkinsonian variant of multiple system atrophy is a neurodegenerative disorder frequently misdiagnosed as Parkinson’s disease. No early imaging biomarkers currently differentiate these disorders.
Rita Moiron Simões +12 more
doaj +1 more source
Effect of sensory deprivation and locus coeruleus phasic electrical stimulation following the deflection of adjacent whisker on response properties of principal whisker related-neurons in layer IV of rat barrel cortex [PDF]
Background: Barrel cortex of rodents is responsible for sensory information processing via facial whiskers. Locus coeruleus (LC), main source of cortical norepinephrine (NE), influences tactile sensory processing.
شمسی زاده, علی +4 more
core
Locus coeruleus and dopaminergic consolidation of everyday memory [PDF]
, 2016 The retention of episodic-like memory is enhanced, in humans and animals, when something novel happens shortly before or after encoding. Using an everyday memory task in mice, we sought the neurons mediating this dopamine-dependent novelty effect ...
Yamasaki, Miwako +33 more
core +2 more sources
Clinical Obesity, Volume 15, Issue 2, April 2025.Summary Chronic stress, characterized by increased long‐term exposure to the glucocorticoid hormone cortisol, is increasingly linked to obesity development. Still, various knowledge gaps persist, including on underlying pathophysiological mechanisms. The aim of the current review is to provide the latest insights on the connection between stress and ...
Robin Lengton +4 more
wiley +1 more source
ASL Metabolically Regulates Tyrosine Hydroxylase in the Nucleus Locus Coeruleus
Cell Reports, 2019 Summary: Patients with germline mutations in the urea-cycle enzyme argininosuccinate lyase (ASL) are at risk for developing neurobehavioral and cognitive deficits. We find that ASL is prominently expressed in the nucleus locus coeruleus (LC), the central
Shaul Lerner +34 more
doaj +1 more source
Neuropsychiatric‐Led Presentation of Late‐Onset Parkin‐Related Parkinson's Disease
Movement Disorders Clinical Practice, EarlyView.
Sarah Fullam +4 more
wiley +1 more source