Results 81 to 90 of about 31,294 (247)

Implantable Brain–Machine Interface for Olfactory Neural Regulation in Bioelectronic Nose: A Review

Sensory Neuroscience, EarlyView.
The olfactory Brain‐Machine Interface described in this paper bypasses damaged peripheral olfactory pathways by implanting stimulation electrodes in the olfactory bulb or higher‐order olfactory cortex, thereby forming a closed‐loop system that integrates signal acquisition, information decoding, and cortical integration.
Chen Wang, Chunmei Tu, Jian Liu, Fangyuan Zhu, Hongjie Du, Zhaoze Yang, Chengcheng Liu, Xuening Zhao   +7 more
wiley   +1 more source

Molecular and Functional Sex Differences of Noradrenergic Neurons in the Mouse Locus Coeruleus

Cell Reports, 2018
Summary: Preclinical work has long focused on male animals, though biological sex clearly influences risk for certain diseases, including many psychiatric disorders.
Bernard Mulvey, Dionnet L. Bhatti, Sandeep Gyawali, Allison M. Lake, Skirmantas Kriaucionis, Christopher P. Ford, Michael R. Bruchas, Nathaniel Heintz, Joseph D. Dougherty   +8 more
doaj   +1 more source

A distinct neuromelanin magnetic resonance imaging pattern in parkinsonian multiple system atrophy

BMC Neurology, 2020
Background Parkinsonian variant of multiple system atrophy is a neurodegenerative disorder frequently misdiagnosed as Parkinson’s disease. No early imaging biomarkers currently differentiate these disorders.
Rita Moiron Simões, Ana Castro Caldas, Joana Grilo, Daisy Correia, Carla Guerreiro, Patrícia Pita Lobo, Anabela Valadas, Marguerita Fabbri, Leonor Correia Guedes, Miguel Coelho, Mario Miguel Rosa, Joaquim J. Ferreira, Sofia Reimão   +12 more
doaj   +1 more source

Human brain matters: Navigating the neuropathology of COVID‐19

Brain Pathology, EarlyView.
Severe COVID‐19 is associated with vascular dysregulation and chronic neuroinflammation, leading to axonal injury and neurodegeneration. In long COVID or PASC, persistent alterations in neuroimaging and biofluid biomarkers reflect ongoing neuronal damage and neuroinflammation, contributing to long‐term neurological symptoms including fatigue, cognitive
Juliana M. Nieuwland, Angelica Scaramuzza, Marianna Bugiani, Wilma D. J. van de Berg, Jinte Middeldorp   +4 more
wiley   +1 more source

ASL Metabolically Regulates Tyrosine Hydroxylase in the Nucleus Locus Coeruleus

Cell Reports, 2019
Summary: Patients with germline mutations in the urea-cycle enzyme argininosuccinate lyase (ASL) are at risk for developing neurobehavioral and cognitive deficits. We find that ASL is prominently expressed in the nucleus locus coeruleus (LC), the central
Shaul Lerner, Elmira Anderzhanova, Sima Verbitsky, Raya Eilam, Yael Kuperman, Michael Tsoory, Yuri Kuznetsov, Alexander Brandis, Tevie Mehlman, Ram Mazkereth, Robert McCarter, Menahem Segal, Sandesh C.S. Nagamani, Alon Chen, Ayelet Erez, Fabienne Dietrich Alber, Talin Babikian, Heidi Bender, Christopher Boys, David Breiger, Corinna Buerger, Peter Burgard, Mina Nguyen-Driver, Benjamin Goodlett, Elizabeth Kerr, Casey Krueger, Eva Mamak, Jacqueline H. Sanz, David Schwartz, Susan Caudle, Arianna Stefanos, Rachel Tangen, Magdalena Walter, Susan Waisbren, Greta Wilkening   +34 more
doaj   +1 more source

A Role for the Locus Coeruleus in the Modulation of Feeding [PDF]

, 2019
Abstract Recent data suggest that LC-NE neurons play a role in fear-induced suppression of feeding, but their endogenous activity in naturally behaving animals has not been explored. We found that endogenous activity of LC-NE neurons was enhanced during food approach and suppressed during food consumption, and that these food-evoked LC ...
Natale R. Sciolino, Madeline Hsiang, Christopher M. Mazzone, Leslie R. Wilson, Nicholas W. Plummer, Jaisal Amin, Kathleen G. Smith, Christopher A. McGee, Sydney A. Fry, Cindy X. Yang, Jeanne M. Powell, Michael R. Bruchas, Alexxai V. Kravitz, Jesse D. Cushman, Michael J. Krashes, Guohong Cui, Patricia Jensen   +16 more
openaire   +1 more source

Glucocorticoids and HPA axis regulation in the stress–obesity connection: A comprehensive overview of biological, physiological and behavioural dimensions

Clinical Obesity, Volume 15, Issue 2, April 2025.
Summary Chronic stress, characterized by increased long‐term exposure to the glucocorticoid hormone cortisol, is increasingly linked to obesity development. Still, various knowledge gaps persist, including on underlying pathophysiological mechanisms. The aim of the current review is to provide the latest insights on the connection between stress and ...
Robin Lengton, Myrte Schoenmakers, Brenda W. J. H. Penninx, Mariëtte R. Boon, Elisabeth F. C. van Rossum   +4 more
wiley   +1 more source

Effect of sensory deprivation and Locus Coeruleus (LC) electrical stimulation on the response properties of layer IV barrel cortex neurons in male rats [PDF]

Introduction: Barrel cortex of rodents is responsible for sensory information processing from muzzle whiskers. Locus coeruleus (LC) as the main source of norepinephrine (NE) in the cortex, is effective on the sensory information processing. Methods:
شمسی زاده, علی, سیاه پشت خاچکی, علی, شیبانی, وحید, شیخکانلوی میلان, حمید, آفرینش, محمدرضا   +4 more
core  

Attenuated selective attention during visual perspective taking in autism: A combined behavior, ERP, and pupillometry study

Journal of Child Psychology and Psychiatry, EarlyView.
Background Altered social cognition in autism may be influenced by difficulties in domain‐general functions, such as selective attention. Here, we manipulated the requirement for selective attention during a visual perspective taking (VPT) task and used neurophysiological indices to delineate underlying mechanisms.
Leonie Polzer, Nico Bast, Sara Boxhoorn, Andreas Mühlherr, Hannah Mössinger, Magdalena Schütz, Christine M. Freitag, Christina Luckhardt   +7 more
wiley   +1 more source

Locus coeruleus stimulation by corticotropin-releasing hormone suppresses in vitro cellular immune responses

, 1994
Previous studies have demonstrated that stressors alter cellular immune system function, and increase the activity of locus coeruleus neurons. Furthermore, stressors increase the release of corticotropin-releasing hormone (CRH) and locus coeruleus ...
S Rassnick, BS Rabin, AF Sved
core   +1 more source