Results 101 to 110 of about 396,285 (245)

Von In‐Silico bis In‐Cerebro – Entwicklung des Orexinrezeptor Antagonisten „Photorexant“ zur Photomodulation In Vitro und im Gehirn der Maus

Angewandte Chemie, Volume 138, Issue 42, 12 October 2026.
Durch einen strukturbasierten Designansatz wurden photoschaltbare Derivate des von der FDA zugelassenen Arzneistoffes Suvorexant entwickelt, gedockt, synthetisiert und pharmakologisch an den Orexin‐1‐ und 2‐Rezeptoren (OX1R und OX2R) charakterisiert.
Marcus Angermann, Marie H. Deventer, Vicente Ledesma‐Martin, Nuno Martinho, Alix Flake, Silvia Mori, Angel Nuñez, Jaime Pignatelli, Rita C. Guedes, Christophe P. Stove, Michael Decker   +10 more
wiley   +1 more source

In Silico to In Cerebro—Development of the Orexin Receptor Antagonist “Photorexant” for Photomodulation In Vitro and in Mouse Brains

Angewandte Chemie International Edition, Volume 65, Issue 42, 12 October 2026.
Following a structure‐based design approach, photoswitchable derivatives of the FDA‐approved drug suvorexant were designed, docked, synthesized, and characterized pharmacologically at the orexin 1 and 2 receptors (OX1R and OX2R). Optimized “photorexant” showed up to an 11‐fold difference in IC50 between photoisomers, enabled dynamic and reversible ...
Marcus Angermann, Marie H. Deventer, Vicente Ledesma‐Martin, Nuno Martinho, Alix Flake, Silvia Mori, Angel Nuñez, Jaime Pignatelli, Rita C. Guedes, Christophe P. Stove, Michael Decker   +10 more
wiley   +1 more source

LOCUS COERULEUS NOREPINEPHRINE IN ACTIVE AVOIDANCE AND REWARD SEEKING BEHAVIOR

Cue driven behavior relies on the ability to appropriately respond to stimuli in the environment to obtain resources (food, water, etc.) or avoid threats/danger.
Rodberg, Ellen
core   +1 more source

Biomarker profiles in late‐life depression and Alzheimer's disease across and beyond the A/T/N framework: A scoping review

Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract Depression and Alzheimer's disease (AD) frequently overlap clinically, and depressive symptoms may signal major depressive disorder, a risk factor for AD, or an early manifestation of neurodegeneration. This scoping review mapped biomarker evidence differentiating depression and AD within and beyond the amyloid/tau/neurodegeneration (A/T/N ...
Yiqi Zhu, Nikitha Damera, Ramkrishna K. Singh, Semere Bekena, Laura Kelble, Katherine McGuire, Yikun Hu, Eden Mersiehazen, Gagan Vijay, Arya Nazif, Ramana Kolady, Liwei Xiang, Xian Liu, Shaney Flores, Kaitlyn Dombrowski, Subrata Pal, Angela Hardi, Kaylin Taylor, Jean‐Francois Trani, Beau M. Ances, Eric J. Lenze, Prashanthi Vemuri, Clifford R. Jack Jr., Ronald C. Petersen, Ganesh M. Babulal   +24 more
wiley   +1 more source

[Selective reduction by serotonin, of neuronal excitation in the locus coeruleus evoked by glutamate].

, 1988
International audienceIn the rat, iontophoretically applied serotonin substantially attenuated the excitation of locus coeruleus neurons evoked by iontophoretic glutamate but not that elicited by acetylcholine.
Akaoka, H, Aston-Jones, G, Chouvet, G
core   +3 more sources

The right temperature at the right time: A framework for understanding thermoregulatory pathophysiology in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract The neuromodulatory subcortical system (NSS) includes thermoregulatory neurons that maintain core body temperature (Tb) and brain temperature within a narrow, diurnally varying range. Cellular pathways in NSS neurons implicated in Alzheimer's disease (AD) may be vulnerable to Tb rhythm disturbance because of their sensitivity to temperature ...
Esther Blessing
wiley   +1 more source

Cognitive impairment in Parkinson disease correlates with loss of cholinergic axon projections to cortex in an autopsy study

Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract INTRODUCTION People with Parkinson's disease (PD) frequently develop dementia. We investigated the relationship between cognitive impairment and the loss of cholinergic axon projections from the nucleus basalis of Meynert to neocortical regions in PD.
Rebecca Miller, Jennifer O'Shea, Laura M. Rosok, Sydney Lim, Erin E. Franklin, Richard J. Perrin, Helen Hwang, Dhruva Dhavale, Joel Perlmutter, Meghan C. Campbell, Paul Kotzbauer   +10 more
wiley   +1 more source

Vascular drivers of cerebrospinal fluid movement and enlarged perivascular spaces

Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract Perivascular spaces (PVSs) facilitate cerebrospinal fluid flow and waste clearance, which are critical for maintaining brain homeostasis. Enlarged PVSs (ePVSs) are an emerging marker of cerebral small vessel disease and are implicated in protein accumulation, neurodegeneration, and cognitive decline.
James D. LeFevre, Yukti Vyas, Angela L. Jefferson   +2 more
wiley   +1 more source

Chronic stress impairs autoinhibition in neurons of the locus coeruleus to increase asparagine endopeptidase activity

eLife
Impairments of locus coeruleus (LC) are implicated in anxiety/depression and Alzheimer’s disease (AD). Increases in cytosolic noradrenaline (NA) concentration and monoamine oxidase A (MAO-A) activity initiate the LC impairment through production of NA ...
Hiroki Toyoda, Doyun Kim, Byeong Geon Koh, Tomomi Sano, Takashi Kanematsu, Seog Bae Oh, Youngnam Kang   +6 more
doaj   +1 more source

Neuropathologic features of cognitively defined Alzheimer's disease subgroups in the Adult Changes in Thought study

Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract BACKGROUND Individuals with Alzheimer's disease (AD) dementia can be subgrouped based on cognitive performance at diagnosis. We compared neuropathology across cognitively defined AD subgroups in the Adult Changes in Thought study. METHODS Scores for memory, executive functioning, language, and visuospatial abilities were derived from the ...
Caitlin S. Latimer, Rod L. Walker, Marika Bogdani, C. Dirk Keene, Amber L. Nolan, Daniel D. Child, Shubhabrata Mukherjee, Seo‐Eun Choi, Michael L. Lee, Connie Nakano, Kelly Ehrlich, Linda K. McEvoy, Paul K. Crane   +12 more
wiley   +1 more source