Results 121 to 130 of about 380,424 (246)
ApoE4 as a Therapeutic Target in Epilepsy: From Pathogenic Mechanisms to Precision Medicine
CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.ApoE4 acts as a key disease modifier in epilepsy by driving neuroinflammation, synaptic dysfunction, metabolic imbalance, and BBB disruption. These interacted mechanisms promote network hyperexcitability and disease progression. Targeting ApoE4 and its downstream pathways offers promising opportunities for precision therapy.
Kang Pan +4 more
wiley +1 more source
Investigating the Contribution of Molecular‐Enriched Functional Connectivity to Brain‐Age Analysis
Human Brain Mapping, Volume 47, Issue 13, September 2026.ABSTRACT Brain‐age prediction from neuroimaging data provides a proxy of biological aging, yet most models rely on structural magnetic resonance imaging (MRI), a modality that captures macroanatomy but offers limited biological specificity. We tested whether integrating molecular‐enriched functional connectivity (FC) from resting‐state functional MRI ...
Marco Pinamonti +4 more
wiley +1 more source
Epilepsia OpenObjective Dissociative seizures are paroxysmal disruptions of awareness and behavioral control in the context of affective arousal. Alterations in stress‐related endocrine function have been demonstrated, but the timescale of dissociation suggests that ...
Samantha Weber +3 more
doaj +1 more source
Migraine: Epidemiology, Risk Factors, Pathophysiology, and Treatment
MedComm, Volume 7, Issue 9, September 2026.Migraine is a highly prevalent, female‐predominant, and disabling brain disorder shaped by genetic susceptibility, hormonal influences, modifiable attack factors, and comorbidity‐related progression. This review integrates current evidence on migraine epidemiology, phase‐specific neurovascular and neuroglial mechanisms, including CGRP signaling and ...
Weiwei Lu +9 more
wiley +1 more source
Neurocardiology: Brain–Heart Interactions in the Heart
MedComm, Volume 7, Issue 9, September 2026.The heart and brain maintain systemic homeostasis through bidirectional communication involving neural, biochemical, and mechanical pathways. Dysregulation of these pathways contributes to a spectrum of conditions involving heart–brain interactions, including Takotsubo syndrome, the epileptic heart, stroke–heart syndrome, heart failure, cardiac ...
Wentao Wang +3 more
wiley +1 more source
Movement Disorders Clinical Practice, Volume 13, Issue 9, Page 2081-2092, September 2026.Abstract Background Non‐motor symptoms, especially autonomic dysfunction, are major contributors to disability and decreased quality of life in Parkinson's disease (PD). Despite being common and having a wide range of clinical facets, exocrine gland dysfunction is still not well recognized and managed.
Renato P. Munhoz +2 more
wiley +1 more source
ChemistryOpen, Volume 15, Issue 9, September 2026.Neurological disorders (NDs) are characterized by substantial loss of specific neurons, with Alzheimer's and Parkinson's diseases being the most frequent NDs and nearly 99% of all “foreign substances” are prohibited from entering the brain by the blood‐brain barrier (BBB) and the blood‐cerebrospinal fluid barrier (CFB).
Nnamdi Ikemefuna Okafor +3 more
wiley +1 more source
Synapse, Volume 80, Issue 5, September 2026.Chronic stress modifies the effect of oxycodone conditioned place preference (Oxy CPP) on corticotropin releasing factor 1 (CRFR1) subcellular distributions in hippocampal subregions. These stress‐ and oxycodone‐induced changes in CRFR1 density may influence sex differences in hippocampal learning and memory processes both at baseline and following Oxy
Dana N. Silberstein +7 more
wiley +1 more source
Regulation of Decision Threshold by the Locus Coeruleus
Abstract A fundamental challenge for decision-making under uncertainty lies in regulating the balance between speed and accuracy. Humans and animals solve this problem by adjusting their decision thresholds — the criterion that determines how much information is required before committing to a choice.
Hongjie Xia +3 more
openaire +3 more sources