Results 121 to 130 of about 396,285 (245)
CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.Mice with TLE exhibit significant sleep fragmentation and reduced sleep duration, particularly during non‐rapid eye movement sleep. By employing optogenetic and chemogenetic methods to target CDN glutamatergic neurons, we observed a decrease in sleep fragmentation, an increase in overall sleep duration, and an enhancement in sleep quality among TLE ...
Liang Xia +6 more
wiley +1 more source
Structural morphometry distinguishes vagus nerve stimulation outcomes in individuals with epilepsy
Epilepsia Open, Volume 11, Issue 5, Page 1755-1763, October 2026.Abstract Objective Vagus nerve stimulation (VNS) is a commonly used treatment for drug‐resistant epilepsy. However, response to VNS is variable, while understanding of this response variability is limited. The vagus afferent network (VagAN), the neural circuits thought to be involved in response to vagal afferents, has been implicated in response ...
Harry J. Clifford +9 more
wiley +1 more source
Epilepsia OpenObjective Dissociative seizures are paroxysmal disruptions of awareness and behavioral control in the context of affective arousal. Alterations in stress‐related endocrine function have been demonstrated, but the timescale of dissociation suggests that ...
Samantha Weber +3 more
doaj +1 more source
, 2010 Contains fulltext : 88103reid.pdf (Publisher’s version ) (Closed access)Norepinephrine has been hypothesized to provide a learning and memory signal.
Harley, C.W., Reid, A.T.
core +1 more source
Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 5, October 2026.ABSTRACT Background Amyotrophic lateral sclerosis (ALS) is a devastating neuromuscular disease characterised by progressive muscle wasting and functional decline. Although cortical motor network disruption is a hallmark of ALS, the large‐scale functional hierarchy alterations and their underlying molecular mechanisms in the early stage of the disease ...
Jixin Luan +18 more
wiley +1 more source
Neuropathic Pain: From Mechanisms to Therapeutic Interventions
MedComm, Volume 7, Issue 10, October 2026.Neuropathic pain arises from peripheral nerve injury, central sensitization, neurotransmitter imbalance, neuroimmune activation, and maladaptive circuit remodeling. Clinical phenotyping and multimodal imaging can identify dominant peripheral and central mechanisms.
Yaling Dai +8 more
wiley +1 more source
Tracking Genetic Parkinson's Disease with Molecular Imaging: A Systematic Review
Movement Disorders Clinical Practice, Volume 13, Issue 10, Page 2379-2394, October 2026.Abstract Background Parkinson's disease (PD) is a worldwide, complex neurodegenerative disorder influenced by both genetic and environmental factors. Around 15–20% of PD cases are linked to genetic mutations, providing insights into the disease's pathogenesis.
Chiara Meneghini +5 more
wiley +1 more source
Pharmacology Research &Perspectives, Volume 14, Issue 5, October 2026.From symptom relief to multimodal care: duloxetine and amitriptyline may reduce established CIPN‐related pain and provide a therapeutic foundation for future combination strategies. ABSTRACT Chemotherapy‐induced peripheral neuropathy (CIPN) is a prevalent and debilitating complication of cancer treatment, characterized by neuropathic pain, sensory ...
Rosamaria Caminiti +13 more
wiley +1 more source
Regulation of Decision Threshold by the Locus Coeruleus
Abstract A fundamental challenge for decision-making under uncertainty lies in regulating the balance between speed and accuracy. Humans and animals solve this problem by adjusting their decision thresholds — the criterion that determines how much information is required before committing to a choice.
Hongjie Xia +3 more
openaire +3 more sources