Results 121 to 130 of about 52,640 (225)

Propofol regulates arousal by enhancing inhibitory synaptic transmission of noradrenergic neurons in the locus coeruleus of adult male mice

Scientific Reports
Locus coeruleus-noradrenergic (LC-NA) neurons have been suggested to be involved in the effects of general anesthetics. However, the contribution of LC-NA neurons during propofol anesthesia remains unknown.
Tatsuya Abe, Miyuki Kurabe, Yuka Nakamura, Mika Sasaki, Yutaka Seino, Kenta Furutani, Masaki Ueno, Hiroshi Baba   +7 more
doaj   +1 more source

Attenuated pupillary response during visual search in preclinical Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 4, April 2026.
Abstract INTRODUCTION The locus coeruleus is among the earliest brain regions affected by tau pathology in Alzheimer's disease (AD), but the functional impact is difficult to measure in vivo. Task‐evoked pupil dilation provides an index of locus coeruleus–norepinephrine function that might be altered in cognitively normal older adults with underlying ...
Elena K. Festa, William C. Heindel, Camille A. Marangi, Britney Escobedo, Douglas R. Galasko, David P. Salmon, Jingjing Zou, Diane M. Jacobs   +7 more
wiley   +1 more source

Olfactory decline tracks central‐to‐peripheral spread of tau pathology in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 4, April 2026.
Abstract INTRODUCTION Olfactory decline often precedes cognitive symptoms in Alzheimer's disease (AD) and is linked to tau pathology. Yet, whether tau aggregates start in peripheral olfactory structures or spread from central regions remains debated. METHODS We analyzed 34 post mortem human olfactory bulb (OB) and 2 neuroepithelium (ONE) samples across
Kamar Bouchoucha, Lisa Collin, Céline Coquette, Lise Colmant, Emilien Boyer, Lara Huyghe, Lisa Quenon, Thomas Gerard, Yasmine Salman, Valérie Hox, Pascal Kienlen‐Campard, Bernard Hanseeuw, Anabelle Decottignies, Caroline Huart   +13 more
wiley   +1 more source

Use of anti–amyloid‐β monoclonal antibodies in persons with Down syndrome Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 4, April 2026.
Abstract INTRODUCTION The recent development and licensing of anti–amyloid‐β monoclonal antibodies for the treatment of early‐stage Alzheimer's disease have significantly shifted the clinical landscape. However, current use recommendations preclude the administration of these new drugs to persons who have Down syndrome.
Clíona Farrell, Fedal Saini, Mona M. Beidas, Natalie S. Ryan, Andre Strydom, Frances K. Wiseman   +5 more
wiley   +1 more source

Neurophysiological responses to stressful motion and anti-motion sickness drugs as mediated by the limbic system [PDF]

Performance is characterized in terms of attention and memory, categorizing extrinsic mechanism mediated by ACTH, norepinephrine and dopamine, and intrinsic mechanisms as cholinergic.
Kohl, R. L., Odell, S.
core   +1 more source

Locus coeruleus degeneration is associated with cortical tau deposition and cognitive decline in older adults at familial risk of Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 4, April 2026.
Abstract INTRODUCTION The locus coeruleus (LC) is among the first sites of tau pathology in Alzheimer's disease (AD) and may seed neocortical tau. METHODS We used longitudinal neuromelanin‐sensitive MRI to assess LC integrity in vivo in a cohort of cognitively unimpaired older adults with familial risk of AD in relation to tau and amyloid positron ...
Alfie Wearn, Kate M. Onuska, Hayley R. C. Shanks, Rahul Gaurav, Stéphane Lehéricy, Giulia Baracchini, Colleen Hughes, Jennifer Tremblay‐Mercier, Sridar Narayanan, John Breitner, Judes Poirier, Taylor W. Schmitz, Gary R. Turner, R. Nathan Spreng, for the PREVENT‐AD Research Group   +14 more
wiley   +1 more source

Global and Regional Vigilance: Are There Two Types of Local Sleep?

Brain and Behavior, Volume 16, Issue 4, April 2026.
The term local sleep as it is used in the literature is confusing and probably consists of two types of brain states. The first one originates from increased activity in certain cortical areas during waking, resulting in increased activity in the slow‐waves range in that same area during subsequent NREM sleep. The second one consists of local states in
Tom Deboer
wiley   +1 more source

Locus coeruleus co‐activation patterns at rest show higher state persistence in patients with dissociative seizures: A Pilot Study

Epilepsia Open
Objective Dissociative seizures are paroxysmal disruptions of awareness and behavioral control in the context of affective arousal. Alterations in stress‐related endocrine function have been demonstrated, but the timescale of dissociation suggests that ...
Samantha Weber, Johannes Jungilligens, Selma Aybek, Stoyan Popkirov   +3 more
doaj   +1 more source

Quantification of multi-lumen blood vessel pathology in chronic traumatic encephalopathy [PDF]

, 2017
BACKGROUND: Chronic Traumatic Encephalopathy (CTE) is a neurodegenerative disorder that had been largely ignored for decades since its initial characterization in 1928 by Dr. H. Martland. Within the last several years, a dramatic increase of attention in
Dell'Aquila, Kevin
core  

Sleep‐Dependent Clearance of Brain Metabolites via the Glymphatic System: Implications for Alzheimer's Pathophysiology

Brain and Behavior, Volume 16, Issue 4, April 2026.
Slow‐wave sleep promotes glymphatic transport through coordinated norepinephrine dynamics, vasomotion, and polarized AQP4‐dependent fluid exchange, thereby facilitating clearance of amyloid‐beta and tau. In contrast, sleep disruption, aging, vascular dysfunction, and AQP4 abnormalities impair this system and may accelerate Alzheimer‐related pathology ...
Farshad Zare, Gulnora Shakhmurova, Jasur Rizaev, Aseel Smerat, Rosull Saadoon Abbood, Vinay Patil, Manoj Kumar‐Mishra   +6 more
wiley   +1 more source