Results 121 to 130 of about 31,294 (247)

Neural and Navigational Features Influencing the Novelty Induced Benefits on Episodic Memory

Hippocampus, Volume 36, Issue 4, July 2026.
ABSTRACT Studies in animals have robustly shown that exposure to novelty can promote memory for information presented in the temporal vicinity. In humans, however, evidence for such novelty‐related memory benefits has been mixed. In this EEG study, we investigated the neurobiological mechanisms underlying effects of novelty on memory and whether ...
David A. Vogelsang, Carla Maló Calmus, Madeleine Vohs, Kreeta I. L. Kerkkänen, Svetlin Hansov, Judith Schomaker   +5 more
wiley   +1 more source

Chemogenetic Stimulation of the Dorsal Motor Nucleus of the Vagus Mitigates Autonomic Dysfunction and Memory Decline in Rat Model of Alzheimer‐Like Disease

Acta Physiologica, Volume 242, Issue 7, July 2026.
ABSTRACT Aim To test the hypothesis that Alzheimer‐like metabolic neurodegeneration rat model leads to an autonomic dysfunction, memory impairment, and hippocampal amyloid pathology and that long‐term chemogenetic stimulation of the dorsal motor nucleus of the vagus reverses these alterations. Methods Male and female transgenic Long Evans rats received
Beatriz Pacheco Sousa, Karoline Martins dos Santos, Vagner Roberto Antunes   +2 more
wiley   +1 more source

Chronic stress impairs autoinhibition in neurons of the locus coeruleus to increase asparagine endopeptidase activity

eLife
Impairments of locus coeruleus (LC) are implicated in anxiety/depression and Alzheimer’s disease (AD). Increases in cytosolic noradrenaline (NA) concentration and monoamine oxidase A (MAO-A) activity initiate the LC impairment through production of NA ...
Hiroki Toyoda, Doyun Kim, Byeong Geon Koh, Tomomi Sano, Takashi Kanematsu, Seog Bae Oh, Youngnam Kang   +6 more
doaj   +1 more source

A Central Somatic Transmission Mediates Proprioceptive Facilitation of Muscle Pain

Advanced Science, Volume 13, Issue 34, 19 June 2026.
Zhang et al. uncover a novel central mechanism for persistent muscle pain, in which TRPA1 sensitization in MeV proprioceptive neurons enhances somatic secretion. This, in turn, disinhibits descending pain control from neighboring noradrenergic locus coeruleus neurons via local GABAergic circuits, thereby promoting inflammatory muscle pain.
Xiaoyu Zhang, Jiale Yang, Xi Wu, Jie Li, Fujian Lu, Yiman Li, Xingyu Du, Rong Huang, Jamila Asgar, Jing Wang, Ke Ren, Feipeng Zhu, Changhe Wang, Yehua Gan, Feng Wei, Zhuan Zhou   +15 more
wiley   +1 more source

Partial or Complete Loss of Norepinephrine Differentially Alters Contextual Fear and Catecholamine Release Dynamics in Hippocampal CA1

Biological Psychiatry Global Open Science
Background: Contextual fear learning is heavily dependent on the hippocampus. Despite evidence that catecholamines contribute to contextual encoding and memory retrieval, the precise temporal dynamics of their release in the hippocampus during behavior ...
Leslie R. Wilson, Nicholas W. Plummer, Irina Y. Evsyukova, Daniela Patino, Casey L. Stewart, Kathleen G. Smith, Kathryn S. Konrad, Sydney A. Fry, Alex L. Deal, Victor W. Kilonzo, Sambit Panda, Natale R. Sciolino, Jesse D. Cushman, Patricia Jensen   +13 more
doaj   +1 more source

Locus coeruleus-CA1 projections are involved in chronic depressive stress-induced hippocampal vulnerability to transient global ischaemia

Nature Communications, 2019
Depression and transient ischaemic attacks are tightly regulated but the neural circuits underlying depression-modulated ischaemic injury are not known.
Qian Zhang, Dian Xing Hu, Feng He, Chun Yang Li, Guang Jian Qi, Hong Wei Cai, Tong Xia Li, Jie Ming, Pei Zhang, Xiao Qian Chen, Bo Tian   +10 more
doaj   +1 more source

Neuromodulator Dynamics Underlying Associative Learning in the Ventral Striatum's Olfactory Tubercle

Advanced Science, Volume 13, Issue 32, 9 June 2026.
Using fiber photometry and genetically encoded sensors, the dynamic release patterns of four neuromodulators in the olfactory tubercle (OT)—a brain region overlapping with the olfactory cortex and ventral striatum—were systematically monitored in response to external rewards and distinct reward‐associated learning processes.
Maojun Hong, Liuting Zou, Yiqing Chen, Juan Guo, Zhixiang Xu, Tong Ma, Shuaishuai Hu, Rongfeng K. Hu   +7 more
wiley   +1 more source

A lifespan staging model of basal forebrain cholinergic vulnerability

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract The cholinergic neurons of the basal forebrain are among the most vulnerable cell types to age‐ and Alzheimer's disease‐related dysfunction and neurodegeneration. However, the biological bases of basal forebrain cholinergic vulnerability (the why) and the temporal sequence (the how) have yet to be fully resolved.
Hayley R. C. Shanks, Sherry Chen, Kate M. Onuska, Taylor W. Schmitz   +3 more
wiley   +1 more source

Regional locus coeruleus degeneration is uncoupled from noradrenergic terminal loss in Parkinson’s disease [PDF]

Previous studies have reported substantial involvement of the noradrenergic system in Parkinson’s disease. Neuromelanin-sensitive MRI sequences and PET tracers have become available to visualize the cell bodies in the locus coeruleus and the density of ...
Borghammer P, Fedorova TD, Schaldemose JL, Kinnerup MB, Doppler CEJ, Fink GR, Brooks DJ, Betts M, Stær K, Brune C, Ismail R, Sommerauer M, Knudsen K, Nahimi A, Seger AD, Hansen AK, Farrher E   +16 more
core  

Reduction in hippocampal cholinergic neurostimulating peptide enhances memory impairment in AppNL‐G‐F KI mice

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract INTRODUCTION Whether cholinergic activity in the septohippocampal network affects cognitive dysfunction via hippocampal cholinergic neurostimulating peptide (HCNP) in Alzheimer's pathogenesis remains unclear. METHODS An Alzheimer's pathogenesis by mutation in amyloid‐beta precursor protein gene (AppNL‐G‐F) knock‐in (KI) and HCNP precursor ...
Yo Tsuda, Yuta Madokoro, Kengo Suzuki, Takuya Ooba, Toyohiro Sato, Yuto Uchida, Itsumi Nagai‐Arakawa, Takashi Saito, Hideaki Hara, Hideki Hida, Noriyuki Matsukawa   +10 more
wiley   +1 more source