Results 141 to 150 of about 52,640 (225)

Molecular Pathogenesis of Memory Impairment in Parkinson's Disease: An Exploration of Underlying Mechanisms

Health Science Reports, Volume 9, Issue 4, April 2026.
ABSTRACT Background and Aim Parkinson's disease (PD) is primarily known for its motor symptoms but is increasingly recognized for its substantial cognitive effects, particularly on memory. This narrative review aims to clarify the complex molecular mechanisms contributing to memory impairment in PD by integrating findings from both animal and clinical ...
Mohammad Pourfridoni, Zohreh Hakemi, Habibeh Mashayekhi‐sardoo, Yousef Baghcheghi   +3 more
wiley   +1 more source

Unraveling Chronic Pain: From Mechanisms and Risks to Diagnosis and Treatment

MedComm, Volume 7, Issue 4, April 2026.
Chronic pain arises through distinct molecular pathways categorized into nociceptive, neuropathic, and nociplastic types. Nociceptive pain begins with TRP channel activation in peripheral nociceptors, signaling via Aδ‐ and C‐fibers through the spinal dorsal horn and spinothalamic tracts to the brain, regulated by descending inhibition and involving ...
Xiaofeng Dai, Chongxiang Wang, Ping Jiang, Xiaopeng Mei   +3 more
wiley   +1 more source

Emerging Neural Recording and Neurostimulation Technologies Based on Brain–Computer Interface: A Promising Approach for Neuropsychiatric Disorders

MedComm, Volume 7, Issue 4, April 2026.
This review explores brain–computer interface (BCI)–based neural recording and stimulation for treating neuropsychiatric disorders. It details three emerging technologies: endovascular BCI for minimally invasive signal acquisition, BCI‐integrated epidural spinal cord stimulation for motor restoration, and closed‐loop deep brain stimulation for adaptive
Yeguang Xu, Danyang Chen, Qing Ye, Peng Zhang, Jian Shi, Shengjie Li, Yuhao Sun, Zhixian Zhao, Yingxin Tang, Ping Zhang, Zhouping Tang   +10 more
wiley   +1 more source

Monoaminergic Networks of Cognitive and Behavioral Symptoms in Early Parkinson's Disease

Movement Disorders, Volume 41, Issue 4, Page 1004-1015, April 2026.
Abstract Background Parkinson's disease (PD) is associated with several behavioral and cognitive symptoms, the neurobiological background of which is not yet fully understood. Objectives The aim was to investigate the association between monoamine function and four specific nonmotor symptoms in early PD using the Parkinson's Progression Markers ...
Kalle J. Niemi, Valtteri Kaasinen, Rimona S. Weil, Juho Joutsa   +3 more
wiley   +1 more source

Pain Modulation and Central Sensitization in Painful Diabetic Peripheral Neuropathy: Updated Narrative Review and Future Directions

Journal of Diabetes, Volume 18, Issue 4, April 2026.
Alterations within the central nervous system in painful diabetic peripheral neuropathy. Collectively, the changes in forebrain–thalamus connectivity, midbrain–brainstem projections and activities, and hindbrain structures weaken descending modulation of spinal sensory neurons, thereby increasing central sensitization.
Di Ye, Timothy J. Fairchild, Lechi Vo, Peter D. Drummond   +3 more
wiley   +1 more source

An fMRI examination of the role of the Locus Coeruleus in state regulation in ADHD. [PDF]

Imaging Neurosci (Camb)
Drescher LH, Hall JM, Eayrs JO, Krebs RM, Boehler CN, Wiersema JR.   +5 more
europepmc   +1 more source

In Vivo Imaging of Neuronal Activity Shifts in the Somatosensory Cortex After Morphine Tolerance in Mice

Addiction Biology, Volume 31, Issue 4, April 2026.
Morphine tolerance drives reorganization of neuronal activity in the somatosensory cortex. ABSTRACT Morphine is widely used to treat severe pain, but its analgesic effect diminishes with repeated use due to the development of tolerance. Reversing this tolerance remains a clinical challenge, as its underlying mechanisms are complex and not fully ...
Guangyan Zhang, Weiwei Meng, Ling‐Jun Xu, Bin Mou, Zongqin Xiang, Xiangcai Ruan, Yong U. Liu, Haihua Shu   +7 more
wiley   +1 more source

Locus coeruleus-amygdala circuit disrupts prefrontal control to impair fear extinction. [PDF]

Proc Natl Acad Sci U S A
Bayer H, Binette AN, Sweck SO, Juliano VAL, Plas SL, Ferst LM, Hassell JE, Mourão FAG, Maren S.   +8 more
europepmc   +1 more source

Sex Differences in the Effects of Etonogestrel on Respiratory Recovery in an In Vivo Rat Model of Central Chemoreflex Impairment

Acta Physiologica, Volume 242, Issue 4, April 2026.
ABSTRACT Aim Rhythmic breathing movements driven by the brainstem rely on chemosensory inputs to homeostatically adjust motor output to the prevailing metabolic demand. The central CO2 chemoreflex is a critical component of this neural circuitry, as defects in these sensors cause hypoventilation syndromes, which are typically difficult to manage ...
Silvia Cardani, Tara A. Janes, Ryaad Asif, Silvia Pagliardini   +3 more
wiley   +1 more source

Impact of chronic alcohol and stress on midlife cognition and locus coeruleus integrity in mice. [PDF]

Alcohol Clin Exp Res (Hoboken)
Revka O, Belculfine SJ, Fitts L, Nippert KE, Teves CAF, Reis PM, Tenney S, Packer BE, Garcia Alvarez I, Milstein O, Coutinho da Silva M, Moorman DE, Vazey EM.   +12 more
europepmc   +1 more source