Results 151 to 160 of about 52,640 (225)

Exploring heart rate variability as a biomarker for frailty: A narrative review

European Journal of Clinical Investigation, Volume 56, Issue 4, April 2026.
Frailty arises from progressive multisystem dysregulation, prompting interest in biomarkers that capture declining physiological reserve. This review positions heart rate variability (HRV) within this evolving biomarker landscape, outlining its physiological basis, analytical domains and relevance to clinical research.
Luca Tagliafico, Silvia Ottaviani, Riccardo Balzano, Stefania Peruzzo, Alessio Nencioni, Fiammetta Monacelli   +5 more
wiley   +1 more source

Cellular signatures of melanocortin pathway genes across the locus coeruleus. [PDF]

Acta Neuropathol Commun
Basak A, Erol FMB, De Rosa MC, Dong Z, Ogbolu V, Glover HJ, Rausch R, Hargus G, Creus-Muncunill J, Buchanan H, Bai Y, Su Q, Chang B, Adler C, Flaherty D, Ciener B, Xiao H, Reddy H, Aime-Wilson P, Reitz C, Sleeman MW, Altarejos JY, Leibel RL, Qiang LO, Teich AF, Doege CA.   +25 more
europepmc   +1 more source

Reverse Hierarchical Processing of Speech in Talker Identification

European Journal of Neuroscience, Volume 63, Issue 8, April 2026.
Beyond replicating the well‐established language familiarity effect—better talker identification in the native (English) versus unfamiliar (Mandarin) language—we incorporated drift‐diffusion model, error pattern analysis, and pupillometry to understand the time course dynamics of talker learning.
Ja Young Choi, Shengyue Xiong, Jacie R. McHaney, Bharath Chandrasekaran   +3 more
wiley   +1 more source

Relationship between locus coeruleus and slow-wave sleep in aging and Alzheimer's disease. [PDF]

Alzheimers Dement
Falgàs N, Tort-Colet N, Martín-Sobrino I, Mayà G, Peña-González M, Rudilosso S, Gaig C, Bosch B, Arqueros A, Pérez-Millan A, Tort-Merino A, Fernández-Villullas G, Piñol-Ripoll G, Balasa M, Lladó A, Ruiz MM, Muñoz-Moreno E, Grau-Rivera O, Iranzo A, Grinberg LT, Sánchez-Valle R.   +20 more
europepmc   +1 more source

Hierarchical error processing : different errors, different systems

, 2007
Holroyd, Clay, Krigolson, Olav E.
core   +1 more source

Alpha‐2‐adrenoreceptor agonists as analgesic drugs in equine medicine

Equine Veterinary Education, Volume 38, Issue 4, Page 220-228, April 2026.
Summary Managing pain in horses is challenging despite the availability of nonsteroidal anti‐inflammatory drugs, local anaesthetics, opioids and α2‐adrenoreceptor agonists. While α2‐agonists are widely used for sedation and restraint, their analgesic properties remain underutilised.
J. A. E. Hubbell, J. Brandly, W. W. Muir III, J. Page, K. Hopster   +4 more
wiley   +1 more source

A Novel Mouse Model of Sympathoadrenal Catecholamine Deficiency by Ablation of the Tyrosine Hydroxylase Gene With Slc6a4‐Cre

Journal of Neurochemistry, Volume 170, Issue 4, April 2026.
Tyrosine hydroxylase (TH) is a rate‐limiting enzyme for catecholamine synthesis. In this study, we generated a novel Th gene conditional knockout mouse line by crossing Th‐flox mice with Slc6a4‐Cre mice. To our surprise, TH expression was largely lost in the adrenal medulla and sympathetic neurons in the conditional knockout mice.
Ryohei Ogawa, Ryo Fukumoto, Satoshi Hara, Nobuhiro Hayashi, Hiroshi Ichinose   +4 more
wiley   +1 more source

Sex and life experience shape locus coeruleus pretangle tau pathology. [PDF]

Alzheimers Dement
Hasan Z, Torraville SE, Omoluabi T, Maziar A, Belolise ON, MacGowan LA, Flynn CM, Reinhardt C, Walling SG, Benoukraf T, Yuan Q.   +10 more
europepmc   +1 more source

Noradrenergic inhibition of definitive POMC neurons through direct and indirect mechanisms

Journal of Neuroendocrinology, Volume 38, Issue 4, April 2026.
Norepinephrine and the α2‐adrenoceptor agonist UK 14,304 robustly inhibit definitive arcuate POMC neurons. Direct inhibition is mediated by ADRA2A‐dependent activation of potassium conductances, while additional indirect mechanisms also contribute. In vivo, inducible POMC‐specific Adra2a deletion minimally affects energy balance and modestly impairs ...
Olivier Lavoie, Audrey Turmel, Axelle Khouma, Moein Minbashi Moeini, Chen Liu, Natalie J. Michael, Alexandre Caron   +6 more
wiley   +1 more source

Sleep Slow Wave‐Bistability and the Connection Between the Sleeping Brain and the Environment—Neurobiological Considerations

Journal of Sleep Research, Volume 35, Issue 2, April 2026.
Bistability is an inherent working mode of NREM sleep. Those bistable patterns ‐ sleep slow waves, K‐complexes, and the cyclic alternating pattern (on a longer, several seconds' time‐scale) ‐ have a double function; they protect sleep and provide an interface between the brain and the environment for information‐transfer during sleep.
Péter Halász, Anna Szűcs, Carlotta Mutti, Liborio Parrino   +3 more
wiley   +1 more source