Results 151 to 160 of about 31,294 (247)

Social activity mediates locus coeruleus tangle-related cognition in older adults

The locus coeruleus-noradrenaline system regulates brain-wide neural activity involved in cognition and behavior. Integrity of this subcortical neuromodulatory system is proposed to be a substrate of cognitive reserve that may be strengthened by lifetime
Zide, Benjamin S, Bennett, David A, Donovan, Nancy J, Jacobs, Heidi I L, Lee, Soyoung, Nag, Sukriti   +5 more
core   +1 more source

The Long Haul: Microtubule Motors as the Essential Supply Line for Neuronal Longevity

Journal of Neurochemistry, Volume 170, Issue 6, June 2026.
To survive a lifetime, neurons depend on a high‐fidelity logistics network powered by microtubule motors. We explore how a broad spectrum of genetic defects in this machinery drive a devastating spectrum of neurodevelopmental and neurodegenerative diseases, including Hereditary Spastic Paraplegia (HSP), Charcot–Marie‐Tooth Type 2 (CMT2), and ...
Emma D. Turner, Alison E. Twelvetrees
wiley   +1 more source

Stimulus Predictability and Liking Enhance Auditory–Motor Encoding and Memory for Melodies

Annals of the New York Academy of Sciences, Volume 1560, Issue 1, June 2026.
Musical predictability significantly affects how we judge music. Through a combination of expectations and surprises, music shapes the pleasure we experience while listening. This pleasure can be measured using metrics of physiological arousal such as pupil size.
Alexander W. Albury, Roberta Bianco, Aaron P. Johnson, Virginia B. Penhune   +3 more
wiley   +1 more source

The Pupil‐Brain System at Rest: Spontaneous Pupil Fluctuations as Markers of Neuromodulatory and Network Dynamics

Psychophysiology, Volume 63, Issue 6, June 2026.
ABSTRACT Spontaneous pupil fluctuations (SPFs) during rest provide a non‐invasive, low‐cost index of central arousal dynamics, independent of cognitive task demands. These features position SPFs as promising markers for baseline neurophysiological activity in both basic and translational research. This review synthesizes current evidence on the resting‐
T. Liu, S. A. Kotz, A. Criscuolo, M. Schwartze   +3 more
wiley   +1 more source

Regulation of Decision Threshold by the Locus Coeruleus

Abstract A fundamental challenge for decision-making under uncertainty lies in regulating the balance between speed and accuracy. Humans and animals solve this problem by adjusting their decision thresholds — the criterion that determines how much information is required before committing to a choice.
Hongjie Xia, Maxime Maheu, Gary A. Kane, Benjamin B. Scott   +3 more
openaire   +3 more sources

Locus coeruleus modulation of prefrontal dynamics during attentional switching in mice. [PDF]

Elife
Nigro M, Silva Tortorelli L, Garad M, Zlebnik N, Yang H.   +4 more
europepmc   +1 more source

Lower Locus Coeruleus Integrity Signals Elevated Entorhinal Tau and Clinical Progression in Asymptomatic Older Individuals

Objective: Elevated entorhinal cortex (EC) tau in low beta-amyloid individuals can predict accumulation of pathology and cognitive decline. We compared the accuracy of magnetic resonance imaging (MRI)-derived locus coeruleus integrity, neocortical beta ...
Jacobs, Heidi I. L., Kwong, Kenneth K., Sperling, Reisa A., Riphagen, Joost M., Becker, J. Alex, Van Egroo, Maxime, Johnson, Keith A., Rentz, Dorene M., Prokopiou, Prokopis C., Bueicheku, Elisenda, Smegal, Lindsay F., Salat, David H., Engels-Dominguez, Nina, Koops, Elouise A.   +13 more
core   +1 more source

An fMRI examination of the role of the Locus Coeruleus in state regulation in ADHD. [PDF]

Imaging Neurosci (Camb)
Drescher LH, Hall JM, Eayrs JO, Krebs RM, Boehler CN, Wiersema JR.   +5 more
europepmc   +1 more source

Locus coeruleus-amygdala circuit disrupts prefrontal control to impair fear extinction. [PDF]

Proc Natl Acad Sci U S A
Bayer H, Binette AN, Sweck SO, Juliano VAL, Plas SL, Ferst LM, Hassell JE, Mourão FAG, Maren S.   +8 more
europepmc   +1 more source

Stereological Assessment of Locus Coeruleus in the Mouse: A Methodological Study in Pups and Adult Animals. [PDF]

Methods Protoc
Scotto M, Galgani A, Boido M, Mohammady N, Vercelli A, Giorgi FS.   +5 more
europepmc   +1 more source