Results 151 to 160 of about 411,191 (267)

Refined Division of Sleep Stages in the Mouse Based on Distributed Deep Electrodes and Underlying Infra‐Slow Oscillation

Journal of Sleep Research, Volume 35, Issue 4, August 2026.
ABSTRACT The mouse sleep is mostly recorded with only epidural electrodes and divided simply into NREM and REM stages. With the help of distributed intracerebral triplet electrodes, we searched for possible new electrophysiological signatures to characterise more specific sleep substages within the timeframe of seconds to tens of minutes.
Nanxiang Jin, Sara Häkli, Keerthana Malathi, Hennariikka Koivisto, Theodor Boc, Jonas Schimmel, Eric Castell‐Caubet, Irina Gureviciene, Heikki Tanila   +8 more
wiley   +1 more source

Unravelling the Significance of Cystatin C and Bunina Bodies in Amyotrophic Lateral Sclerosis Pathogenesis

Neuropathology and Applied Neurobiology, Volume 52, Issue 4, August 2026.
ABSTRACT Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease (MND), is a fatal neurodegenerative disease primarily affecting motor neurons. Two key protein inclusions found in lower motor neurons serve as neuropathological hallmarks of the disease in human tissue: the TDP43‐positive inclusion and the cystatin C‐positive Bunina body.
Sarah M. Granger, Rosemary A. Staniforth, Asbjorg Osk Snorradottir, Johnathan Cooper‐Knock, Kurt J. De Vos, J. Robin Highley   +5 more
wiley   +1 more source

Pharmacology, Medicinal Chemistry, and Therapeutic Potential of Imidazoline Receptor Ligands

ChemMedChem, Volume 21, Issue 13, 14 July 2026.
Building on the excellent review article by Dardonville and Rozas (2004), this paper summarizes the most representative ligands of imidazoline receptors (IR; I1, I2, and I3) and updates their pharmacological profiles. Although not exhaustive, it provides a solid starting point for understanding the significance of I2 IRs as promising therapeutic ...
Maria‐Eleni Kouridaki, Mercè Pallàs, Carmen Escolano   +2 more
wiley   +1 more source

Chronic stress impairs autoinhibition in neurons of the locus coeruleus to increase asparagine endopeptidase activity

eLife
Impairments of locus coeruleus (LC) are implicated in anxiety/depression and Alzheimer’s disease (AD). Increases in cytosolic noradrenaline (NA) concentration and monoamine oxidase A (MAO-A) activity initiate the LC impairment through production of NA ...
Hiroki Toyoda, Doyun Kim, Byeong Geon Koh, Tomomi Sano, Takashi Kanematsu, Seog Bae Oh, Youngnam Kang   +6 more
doaj   +1 more source

Partial or Complete Loss of Norepinephrine Differentially Alters Contextual Fear and Catecholamine Release Dynamics in Hippocampal CA1

Biological Psychiatry Global Open Science
Background: Contextual fear learning is heavily dependent on the hippocampus. Despite evidence that catecholamines contribute to contextual encoding and memory retrieval, the precise temporal dynamics of their release in the hippocampus during behavior ...
Leslie R. Wilson, Nicholas W. Plummer, Irina Y. Evsyukova, Daniela Patino, Casey L. Stewart, Kathleen G. Smith, Kathryn S. Konrad, Sydney A. Fry, Alex L. Deal, Victor W. Kilonzo, Sambit Panda, Natale R. Sciolino, Jesse D. Cushman, Patricia Jensen   +13 more
doaj   +1 more source

Regional locus coeruleus degeneration is uncoupled from noradrenergic terminal loss in Parkinson’s disease [PDF]

Previous studies have reported substantial involvement of the noradrenergic system in Parkinson’s disease. Neuromelanin-sensitive MRI sequences and PET tracers have become available to visualize the cell bodies in the locus coeruleus and the density of ...
Borghammer P, Fedorova TD, Schaldemose JL, Kinnerup MB, Doppler CEJ, Fink GR, Brooks DJ, Betts M, Stær K, Brune C, Ismail R, Sommerauer M, Knudsen K, Nahimi A, Seger AD, Hansen AK, Farrher E   +16 more
core  

Social activity mediates locus coeruleus tangle-related cognition in older adults [PDF]

The locus coeruleus-noradrenaline system regulates brain-wide neural activity involved in cognition and behavior. Integrity of this subcortical neuromodulatory system is proposed to be a substrate of cognitive reserve that may be strengthened by lifetime
Zide, Benjamin S, Bennett, David A, Donovan, Nancy J, Jacobs, Heidi I L, Lee, Soyoung, Nag, Sukriti   +5 more
core   +1 more source

Propofol regulates arousal by enhancing inhibitory synaptic transmission of noradrenergic neurons in the locus coeruleus of adult male mice

Scientific Reports
Locus coeruleus-noradrenergic (LC-NA) neurons have been suggested to be involved in the effects of general anesthetics. However, the contribution of LC-NA neurons during propofol anesthesia remains unknown.
Tatsuya Abe, Miyuki Kurabe, Yuka Nakamura, Mika Sasaki, Yutaka Seino, Kenta Furutani, Masaki Ueno, Hiroshi Baba   +7 more
doaj   +1 more source

Locus coeruleus

Scholarpedia, 2010
Sébastien Bouret, Susan Sara
openaire   +1 more source

Lower Locus Coeruleus Integrity Signals Elevated Entorhinal Tau and Clinical Progression in Asymptomatic Older Individuals [PDF]

Objective: Elevated entorhinal cortex (EC) tau in low beta-amyloid individuals can predict accumulation of pathology and cognitive decline. We compared the accuracy of magnetic resonance imaging (MRI)-derived locus coeruleus integrity, neocortical beta ...
Jacobs, Heidi I. L., Kwong, Kenneth K., Sperling, Reisa A., Riphagen, Joost M., Becker, J. Alex, Van Egroo, Maxime, Johnson, Keith A., Rentz, Dorene M., Prokopiou, Prokopis C., Bueicheku, Elisenda, Smegal, Lindsay F., Salat, David H., Engels-Dominguez, Nina, Koops, Elouise A.   +13 more
core   +1 more source