Results 131 to 140 of about 52,640 (225)

Locus coeruleus MRI contrast is associated with cortical thickness in older adults

open access: yes, 2020
Bachman, S.   +7 more
core   +1 more source

Neuroplasticity‐Driven Mechanisms and Therapeutic Targets in the Anterior Cingulate Cortex in Neuropathic Pain

open access: yesBrain and Behavior, Volume 16, Issue 4, April 2026.
The anterior cingulate cortex (ACC), as the center for pain and emotion integration, causes integration disorders due to excessive synaptic strengthening and glial cell inflammation/synaptic pruning dysregulation. However, traditional drugs have insufficient targeting, and closed‐loop DBS improves symptoms by precisely regulating ACC.
Haibing Xiong   +5 more
wiley   +1 more source

Little Known Facts, Controversies and Misconceptions About Cranial Motor Nuclei (and a New Classification for All Motoneurons, Cranial, and Spinal)

open access: yesJournal of Comparative Neurology, Volume 534, Issue 4, April 2026.
ABSTRACT Cranial nerves represent a notoriously complex province of the neuroanatomical landscape of the vertebrates. Here, we offer a selection of the anatomic, genetic, and developmental features of their efferent component that are often misrepresented, ignored or controversial, as a complement to more exhaustive treatments of the subject.
Margaux Sivori   +2 more
wiley   +1 more source

Predicting Long‐Term Depression Progression in Parkinson's Disease: A Machine‐Learning Survival Analysis and Risk Score

open access: yesCNS Neuroscience &Therapeutics, Volume 32, Issue 4, April 2026.
We developed and internally validated a machine learning–based survival model for predicting long‐term progression of dPD. Supported by SHAP analysis, the model identified that depressive symptom severity, cognitive impairment, and autonomic dysfunction were the main key clinical predictors for dPD progression.
Defu Liu   +14 more
wiley   +1 more source

Transnasal Ventral Brainstem Epidural Electrical Stimulation Enhances Consciousness in Anesthetized Sheep: A Feasibility Study

open access: yesCNS Neuroscience &Therapeutics, Volume 32, Issue 4, April 2026.
This study provides the first experimental evidence of a novel transnasal ventral brainstem epidural electrical stimulation approach in anesthetized sheep and demonstrates that this procedure can induce behavioral arousal and cortical electrophysiological changes toward a wake‐like state, holding promise for the treatment of chronic disorders of ...
Bin Liu   +14 more
wiley   +1 more source

Whole‐Brain Neural Connectivity to Cholinergic Neurons in the Lower Thoracic Intermediolateral Column

open access: yesCNS Neuroscience &Therapeutics, Volume 32, Issue 4, April 2026.
This study establishes a whole‐brain monosynaptic input map to cholinergic neurons in the lower thoracic intermediolateral column (IML) using a cell‐type‐specific retrograde rabies tracing system in ChAT‐Cre mice. Our results reveal a widespread supraspinal network originating from five major brain divisions, including the telencephalon, diencephalon ...
Yuan‐jun Yang   +9 more
wiley   +1 more source

A Review of Vagus Nerve Stimulation for Disease: Comprehensive Theory and Evidence for Mechanisms of Action

open access: yesComprehensive Physiology, Volume 16, Issue 2, April 2026.
Vagus nerve stimulation (VNS) effects span central and peripheral organ systems through diverse mechanistic pathways. This comprehensive review provides a unified synthesis of these mechanisms across neurological, cardiovascular, immunological, metabolic, and gastrointestinal domains, filling a critical gap and serving as a foundational resource for ...
Yifeng Bu   +11 more
wiley   +1 more source

Temporal learning in the cerebellum: The microcircuit model [PDF]

open access: yes
The cerebellum is that part of the brain which coordinates motor reflex behavior. To perform effectively, it must learn to generate specific motor commands at the proper times.
Miles, Coe F., Rogers, David
core   +1 more source

The Brain‐Gut Axis in Parkinson's Disease Pathology

open access: yesComprehensive Physiology, Volume 16, Issue 2, April 2026.
Exposure to environmental toxins induces gut dysbiosis, increases intestinal epithelial barrier permeability, immune activation, and oxidative stress, promoting α‐syn misfolding and propagation. Brainstem DMV neurons exhibit α‐syn pathology, dysregulating neuronal excitability and vagal control of GI functions.
Kudret Selin Ozkaya   +1 more
wiley   +1 more source

Voluntary Attention Selectively Modulates Omission Responses

open access: yesHuman Brain Mapping, Volume 47, Issue 5, 1 April 2026.
Clapping sounds were occasionally omitted from a video (A). While early responses to omissions in the EEG showed similar amplitudes across conditions, larger responses were observed when attention was directed toward the auditory modality (D and E) compared to the visual modality (B and C).
Tjerk T. Dercksen   +2 more
wiley   +1 more source

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