Results 131 to 140 of about 31,294 (247)

Propofol regulates arousal by enhancing inhibitory synaptic transmission of noradrenergic neurons in the locus coeruleus of adult male mice

Scientific Reports
Locus coeruleus-noradrenergic (LC-NA) neurons have been suggested to be involved in the effects of general anesthetics. However, the contribution of LC-NA neurons during propofol anesthesia remains unknown.
Tatsuya Abe, Miyuki Kurabe, Yuka Nakamura, Mika Sasaki, Yutaka Seino, Kenta Furutani, Masaki Ueno, Hiroshi Baba   +7 more
doaj   +1 more source

Stress, stress systems, and Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract Stress is increasingly recognized as an important, modifiable factor for Alzheimer's disease (AD), yet its roles in initiation, progression, and outcomes remain incompletely elucidated. Epidemiologic studies link chronic stress, early‐life adversity, and trauma to increased AD risk, while experimental models have uncovered mechanisms by which ...
Stephanie G. Eberly, Chayarndorn Phumsatitpong, Catherine E. Munro, Thomas C. Neylan, Daniela Kaufer, Alexander J. Ehrenberg   +5 more
wiley   +1 more source

Cortical synchrony is reduced in Alzheimer's disease and relates to arousal state

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract INTRODUCTION The brain is a complex dynamical system, influenced by arousal state. Cortical synchrony supports information processing and is disrupted in Alzheimer's disease (AD). Locus coeruleus (LC) integrity and pupillometry index arousal system structure and function.
Michael C. B. David, Emma‐Jane Mallas, Magdalena A. Kolanko, Martina Del Giovane, Danielle L. Kurtin, Ramin Nilforooshan, Karl A. Zimmerman, Cristina Bonet Olivares, Peter J. Lally, CR&T Group of UKDRI, David J. Sharp, Paresh A. Malhotra, Gregory Scott   +12 more
wiley   +1 more source

Contributions of the Alzheimer's Disease Neuroimaging Initiative to advancing AD research: a targeted review of recent publications

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract The Alzheimer's Disease Neuroimaging Initiative (ADNI) recently celebrated its 20th anniversary, reflecting two decades of major contributions to Alzheimer's research through open data sharing and longitudinal multimodal assessments. This review synthesizes 122 high‐impact studies using ADNI data or biospecimens from 2023 to mid‐2025 to ...
Dallas P. Veitch, Melanie J. Miller, Shaveta Kanoria, Paul S. Aisen, Laurel A. Beckett, Robert C. Green, Danielle J. Harvey, Clifford R. Jack Jr., William Jagust, Edward B. Lee, Kwangsik Nho, Rachel Nosheny, Ozioma C. Okonkwo, Richard J. Perrin, Ronald C. Petersen, Monica Rivera Mindt, Andrew J. Saykin, Leslie M. Shaw, Arthur W. Toga, Duygu Tosun, Susan M Landau, Michael W. Weiner, for the Alzheimer's Disease Neuroimaging Initiative   +22 more
wiley   +1 more source

White matter hyperintensities are associated with locus coeruleus atrophy and astrocytic β2‐adrenergic receptor expression

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract INTRODUCTION White matter hyperintensities (WMHs) are a robust marker of brain aging and dementia risk, typically attributed to vascular pathology. However, impaired astrocytic support may also contribute. The locus coeruleus (LC), which degenerates early in aging and Alzheimer's disease, provides widespread noradrenergic projections that ...
Victor Vidal, Gonzalo Farías, Carolina Delgado, Paul H. Delano, Rodrigo C. Vergara, Patricia Orellana, Tomás Ossandón, Nicolás A. Crossley, Cecilia Gonzalez‐Campo, Sharon L. Naismith, Raul Gonzalez‐Gomez, Carlos Coronel‐Oliveros, Agustín Ibáñez, Gabriel Wainstein, Robert D. Sanders, James M. Shine, Vicente Medel   +16 more
wiley   +1 more source

Locus coeruleus

Scholarpedia, 2010
Sébastien Bouret, Susan Sara
openaire   +1 more source

Corticotropin-Releasing Factor in the Norepinephrine Nucleus, Locus Coeruleus, Facilitates Behavioral Flexibility

, 2012
Corticotropin-releasing factor (CRF), the stress-related neuropeptide, acts as a neurotransmitter in the brain norepinephrine nucleus, locus coeruleus (LC), to activate this system during stress.
Han, Rebecca, Wang, Wei-Wen, McFadden, Kile, Snyder, Kevin, Valentino, RJ (reprint author), Childrens Hosp Philadelphia, Abramson Pediat Res Ctr 402D, Dept Anesthesiol & Crit Care Med, Philadelphia, PA 19104 USA., Valentino, Rita J.   +5 more
core  

Sleep Disturbances Among Yazidi Survivors of the ISIS Genocide: Epidemiology, Neuropsychology, and Culturally Sensitive Interventions

Brain and Behavior, Volume 16, Issue 6, June 2026.
The figure presents an integrative model of sleep disturbances among Yazidi survivors of the 2014 genocide perpetrated by the Islamic State (ISIS). Genocide‐related trauma, including mass violence, sexual violence, displacement, and historical trauma, is associated with sustained neurobiological dysregulation, including hypothalamic–pituitary–adrenal ...
Jan Ilhan Kizilhan, Zelal Ag, Qanta A. Ahmed, Alon Y. Avidan   +3 more
wiley   +1 more source

Complex Regional Pain Syndrome: Why Does Pain Spread From the Injured Limb to the Face?

, 2009
In patients with complex regional pain syndrome (CRPS), sensory disturbances commonly spread outside the affected limb, in particular hemilaterally. Hyperalgesia to pressure-pain was, for instance, documented in the forehead ipsilateral to the affected ...
Knudsen, Lone
core  

Locus coeruleus co‐activation patterns at rest show higher state persistence in patients with dissociative seizures: A Pilot Study

Epilepsia Open
Objective Dissociative seizures are paroxysmal disruptions of awareness and behavioral control in the context of affective arousal. Alterations in stress‐related endocrine function have been demonstrated, but the timescale of dissociation suggests that ...
Samantha Weber, Johannes Jungilligens, Selma Aybek, Stoyan Popkirov   +3 more
doaj   +1 more source